A5101842886- Autoimmune Bullous Skin Diseases
- Gastrointestinal disorders and treatments
- Dermatologic Treatments and Research
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Systemic Sclerosis and Related Diseases
- Cutaneous lymphoproliferative disorders research
- Laser Applications in Dentistry and Medicine
- Gastrointestinal Tumor Research and Treatment
- Autoimmune and Inflammatory Disorders
- Metastasis and carcinoma case studies
- Colorectal and Anal Carcinomas
- Hidradenitis Suppurativa and Treatments
- Eosinophilic Disorders and Syndromes
- Diverticular Disease and Complications
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Esophageal and GI Pathology
- Cancer and Skin Lesions
- Gastrointestinal Bleeding Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Inflammatory Myopathies and Dermatomyositis
- Pancreatic and Hepatic Oncology Research
- Nuclear Receptors and Signaling
- Otolaryngology and Infectious Diseases
Gifu University
2017-2025
National Defense Medical College
1988-2003
Osaka University
2001
St. Marianna University School of Medicine
2000
Saitama Cancer Center
2000
Teikyo University
1997-1999
Osaka Dental University
1996
National Defence Medical Centre
1995
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome has recently been described as an autoinflammatory disease associated with severe adult-onset inflammatory manifestations. The various clinical manifestations include recurrent high-grade fever, neutrophilic dermatoses, cutaneous vasculitis, chondritis of the ear and nose, pulmonary infiltrates, cytopenia, uveitis, gastrointestinal pain or inflammation, aortitis, hepatosplenomegaly, hematological disorders. is caused...
Bullous pemphigoid (BP), an autoimmune subepidermal blistering disease, shows tense blisters associated with urticarial erythema. Tissue-bound Immunoglobulin G (IgG) at the basement membrane zone (BMZ) detected by direct immunofluorescence (DIF) is strong evidence for a diagnosis of BP. The sensitivity DIF higher in complement component 3 (C3) than IgG, but reason this different not fully understood. In study, we performed several ex vivo studies to investigate possible mechanism IgG...
Chinese hamster ovary cell mutants defective in the NPC1 gene (NPC1-trap) were generated by retrovirus-mediated trap mutagenesis from a parental line JP17 expressing an ecotropic retrovirus receptor. Insertion of vector and absence product verified 5'RACE immunological analyses, respectively. NPC1-trap cells showed intracellular accumulation low-density lipoprotein (LDL)-derived cholesterol had increased level unesterified cellular cholesterol. Cholesterol biosynthesis through mevalonate...
ROS are involved in the pathogenesis of bullous pemphigoid (BP), but this involvement has not been fully elucidated. In study, to further elucidate pathogenic role BP, we examined results diacron-reactive oxygen metabolite test and biological antioxidant potential for 16 patients with BP who visited our hospital before being treated systemic corticosteroids. average levels, expressed Carratelli units, were significantly reduced at 1 month treatment (from 335.6 ± 40.3 units 224.7 61.6
Abstract Background Fibrotic diseases are characterized by tissue overgrowth, hardening, and/or scarring because of the excessive production, deposition, and contraction extracellular matrix (ECM). However, detailed mechanisms underlying these disorders remain unclear. It was recently reported that α2-antiplasmin (α2AP) is elevated in fibrotic it associated with development fibrosis. In present study, we examined mechanism production α2AP on Methods To clarify fibrosis, focused high-mobility...
Systemic sclerosis (SSc) is a connective tissue disease of autoimmune origin characterized by fibrosis the skin and visceral organs, peripheral circulatory disturbance. α2‑antiplasmin (α2AP) major circulating inhibitor plasmin key regulator fibrinolysis. It has been demonstrated that expression α2AP elevated in dermal fibroblasts obtained from patients with SSc patients. also determined associated development progression SSc. The present study assessed relationship between matrix...
The authors report on their clinical experience with two new videoendoscopes developed in cooperation Olympus Co. One of them is an instantaneous image method videoendoscope (EVIS 100), the other produces sequential images 200). EVIS 100 as compact a fiberscope; 200 has special advantages electronic magification, use infrared rays and display hemoglobin concentration tissue. In application 245 patients examined 30 cases 200, both instruments were found to be satisfactory terms daily use;...
Background : This prospective study was designed to clarify the present status and problems inherent in endoscopic treatment of early gastric cancer by mucosal resection other modalities Japan investigate possibility extending indications for treatment. Methods A total 409 patients with lesions were enrolled this study. Of these, 219 (182 group I 37 II) evaluated. Results Histological evaluation showed that complete resection, relatively incomplete absolutely carried out 103 (56.6%), 20...
Abstract An 89‐year‐old Japanese woman presented with erythroderma associated significant scaling. A histological examination showed acanthosis hyperkeratosis and hyperkeratinization of the hair follicles. Genetic analyses using DNA from peripheral blood revealed heterozygous mutations in IL36RN (c.115+6T>C) CARD14 c.2648G>A (p.Arg883His). Based on these findings, we diagnosed her attributable to autoinflammatory keratinization disease. She then developed more than 30 small, round,...
Human beta interferon (HuIFN-β) is a natural glycoprotein with antiviral, antiproliferative, and immunomodulatory properties. The administration of HuIFN-β by intravenous (iv) infusion has been shown to have an antiviral effect on HBe antigen-positive chronicactive hepatitis.In order evaluate the pharmacokinetics biological effects iv bolus administrationof HuIFN-βas compared infusion, we studied ten healthy male volunteers whoreceived single injection 3×106IU HuIFN-βby either over5 min or...
［背景と目的］井上らの開発したキャップ吸引粘膜切除法であるEMRC法は，優れた粘膜切除法であるが，フルサクションで行う場合，切除深度のコントロールは困難である。今回，我々はEMRCにより得られた病理組織標本を計測することにより，EMRCの安全性，有用性について検討を行った。［対象と方法］当科においてEMRC法で施行された粘膜切除症例42病変を対象とした。切除検体のHE染色標本を用いて切除最深部粘膜表層及び粘膜筋板との距離を計測し，隆起性病変と平坦・陥凹性病変に分け，比較検討した。また，37病変については切除切片の最大径についても計測を行い，切除深度との関係を検討した。［結果］1）切除最深部と粘膜表層及び粘膜筋板との距離はそれぞれ平均2.19±0.83mm，1.11±0.67mmであった。2）平坦・陥凹性病変の方が隆起性病変より深い位置まで採取される傾向にあった。3）切片最大径と切除深度では明らかな相関は認められなかった。［結論］EMRCでは，特に平坦・陥凹性病変の場合，穿孔に対する注意が必要ではあるが，切除前に十分な局注をすることにより安全な切除が可能と考えられた。また，安定して...