A5026231485- Neuroinflammation and Neurodegeneration Mechanisms
- Zebrafish Biomedical Research Applications
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Single-cell and spatial transcriptomics
- Cerebrovascular and Carotid Artery Diseases
- Galectins and Cancer Biology
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetics and Physical Performance
- Cardiovascular Effects of Exercise
- Physiological and biochemical adaptations
- Signaling Pathways in Disease
- Immune Cell Function and Interaction
- Dental Radiography and Imaging
- Epigenetics and DNA Methylation
- Moyamoya disease diagnosis and treatment
- Cerebral Venous Sinus Thrombosis
- Gestational Diabetes Research and Management
- Acute Ischemic Stroke Management
- Cardiovascular Issues in Pregnancy
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Ischemia and Reperfusion
- Congenital heart defects research
- Mitochondrial Function and Pathology
Université Libre de Bruxelles
2019-2024
Universitat de Barcelona
1968-2018
Institut de Biomedicina de la Universitat de Barcelona
2014
Barcelona Graduate School of Mathematics
1958
Background Zebrafish has been largely accepted as a vertebrate multidisciplinary model but its usefulness for exercise physiology hampered by the scarce knowledge on swimming economy, optimal speeds and cost of transport. Therefore, we have performed individual group-wise experiments to quantify economy demonstrate effects growth in adult zebrafish. Methodology/Principal Findings Individual zebrafish (n = 10) were able swim at critical speed (Ucrit) 0.548±0.007 m s−1 or 18.0 standard body...
The mononuclear phagocytic system consists of many cells, in particular macrophages, scattered throughout the body. However, there is increasing evidence for heterogeneity tissue-resident leading to a pressing need new tools discriminate subsets from other hematopoietic lineages. Macrophage-expressed gene (Mpeg)1.1 an evolutionary conserved encoding perforin-2, pore-forming protein associated with host defense against pathogens. Zebrafish mpeg1.1:GFP and mpeg1.1:mCherry reporters were...
Senegalese sole (Solea senegalensis) and common (S. solea) are two economically evolutionary important flatfish species both in fisheries aquaculture. Although some genomic resources tools were recently described these species, further sequencing efforts required to establish a complete transcriptome, identify new molecular markers. Moreover, the comparative analysis of transcriptomes will be useful understand evolution. A comprehensive characterization transcriptome for each was carried out...
The adult skeletal muscle is a plastic tissue with remarkable ability to adapt different levels of activity by altering its excitability, contractile and metabolic phenotype mass. We previously reported on the potential zebrafish as tractable experimental model for exercise physiology, established optimal swimming speed showed that swimming-induced potentiated somatic growth. Given underlying exercise-induced transcriptional mechanisms regulating mass in vertebrates are not fully understood,...
Macrophages derive from multiple sources of hematopoietic progenitors. Most macrophages require colony-stimulating factor 1 receptor (CSF1R), but some persist in the absence CSF1R. Here, we analyzed
Abstract Background Two decades ago, the fish‐specific monoclonal antibody 4C4 was found to be highly reactive zebrafish microglia, macrophages of central nervous system. This has resulted in being widely used, combination with available fluorescent transgenic reporters identify and isolate microglia. However, target protein remains unidentified, which represents a major caveat. In addition, whether expression pattern is strictly restricted microglial cells never been investigated. Results...
INTRODUCTION: Endovascular technology has revolutionized the treatment of aneurysms, providing less invasive alternatives to traditional surgery. Despite these advances, significant gaps remain where open surgery is still required, particularly for challenging cases such as large, wide-neck middle cerebral artery (MCA) bifurcation aneurysms. These aneurysms often defy standard endovascular due their complex anatomy and high flow dynamics, necessitating innovative solutions bridge this gap....
Glucose transporter 2 (GLUT2; gene name SLC2A2) has a key role in the regulation of glucose dynamics organs central to metabolism. Although GLUT2 been studied context its participation peripheral and sensing, brain is not well understood. To decipher development, we knocked down slc2a2 ( glut2), functional ortholog human GLUT2, zebrafish. Abrogation glut2 led defective organogenesis, reduced uptake increased programmed cell death brain. Coinciding with observed localization expression...
Exercise promotes a set of physiological responses known to provide long-term health benefits and it can play an important role in cardioprotection. In the present study, we examined cardiac exercise training adult zebrafish context regeneration. We found that swimming-induced increased cardiomyocyte proliferation this response was also under regenerating conditions, when performed either prior after ventricular cryoinjury (CI). CI resulted mild improvement function lesion recovery over...
Skeletal muscle is a plastic tissue that undergoes cellular and metabolic adaptations under conditions of increased contractile activity such as exercise. Using adult zebrafish an exercise model, we previously demonstrated swimming training stimulates hypertrophy vascularization fast fibers, consistent with the known growth-promoting effects resulting aerobic capacity this tissue. Here investigated potential involvement factors signaling mechanisms could be responsible for exercise-induced...
Recent studies have highlighted the heterogeneity of immune cell compartment within steady-state murine and human CNS. However it is not known whether this diversity conserved among non mammalian vertebrates, especially in zebrafish, a model system with increasing translational value. Here, we reveal complexity landscape adult zebrafish brain. Using single-cell transcriptomics, characterized these different subpopulations, including types that been -or poorly-characterized so far. By...
ABSTRACT Recent studies have highlighted the heterogeneity of immune cell compartment within steady-state murine and human CNS. However it is not known whether this diversity conserved among non mammalian vertebrates, especially in zebrafish, a model system with increasing translational value. Here, we reveal complexity landscape adult zebrafish brain. Using single-cell transcriptomics, characterized these different subpopulations, including types that been -or poorly-characterized so far....
Nine cases of Moya disease collected since 1968 are presented. The absence inflammatory signs and the high percentage congenital malformations is emphasized. However, despite post-mortem findings in one cases, no etiologic factor has been conclusively demonstrated.
ABSTRACT Background Two decades ago, the fish-specific monoclonal antibody 4C4 was found to be highly reactive zebrafish microglia, macrophages of central nervous system. This has resulted in being widely used, combination with available fluorescent transgenic reporters identify and isolate microglia. However, target protein remains unidentified, which represents a major caveat. In addition, whether expression pattern is strictly restricted microglial cells never been investigated. Results...
Recent studies have highlighted the heterogeneity of immune cell compartment within steady-state murine and human CNS. However it is not known whether this diversity conserved among non mammalian vertebrates, especially in zebrafish, a model system with increasing translational value. Here, we reveal complexity landscape adult zebrafish brain. Using single-cell transcriptomics, characterized these different subpopulations, including types that been -or poorly-characterized so far. By...
ABSTRACT The mononuclear phagocytic system (MPS) consists of many cells, in particular macrophages, scattered throughout the body. However, there is increasing evidence for heterogeneity tissue-resident leading to a pressing need new tools discriminate MPS subsets from other hematopoietic lineages. Mpeg1.1 an evolutionary conserved gene encoding perforin-2 , pore-forming protein associated with host defense against pathogens. Zebrafish mpeg1.1:GFP and mpeg1.1:mCherry reporters were...