A5100624576- Advanced X-ray Imaging Techniques
- Liver Disease Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Pediatric Hepatobiliary Diseases and Treatments
- Medical Imaging Techniques and Applications
- Pancreatitis Pathology and Treatment
- Advanced MRI Techniques and Applications
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Photoacoustic and Ultrasonic Imaging
- Liver physiology and pathology
- Field-Flow Fractionation Techniques
- Organ Transplantation Techniques and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Intestinal Malrotation and Obstruction Disorders
- Seismic Imaging and Inversion Techniques
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Advanced Electron Microscopy Techniques and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced Image Processing Techniques
Tianjin Medical University
2015-2024
Soochow University
2017
First Affiliated Hospital of Soochow University
2017
<h3>Importance</h3> Standard first-line therapy for advanced or metastatic esophageal carcinoma is chemotherapy, but the prognosis remains poor. Camrelizumab (an anti–programmed death receptor 1 [PD-1] antibody) showed antitumor activity in previously treated squamous cell carcinoma. <h3>Objective</h3> To evaluate efficacy and adverse events of camrelizumab plus chemotherapy vs placebo as a treatment <h3>Design, Setting, Participants</h3> This randomized, double-blind, placebo-controlled,...
Background Biliary obstruction leads to an increase in biliary pressure within the system, which induces morphologic adaptation of tree. Purpose To observe and quantify characteristics a bile duct ligation rat model verify it patients with atresia three-dimensional (3D) manner using x-ray phase-contrast CT. Materials Methods A was induced 40 male Sprague-Dawley rats, were divided into five groups: control group (no ligation) groups 2, 4, 6, 8 weeks after (eight animals each group). Liver...
X-ray phase-contrast imaging (PCI) can substantially enhance contrast, and is particularly useful in differentiating biological soft tissues with small density differences. Combined computed tomography (CT), PCI-CT enables the acquisition of accurate microstructures inside samples. In this study, liver microvasculature was visualized without contrast agents vitro using fibrosis samples induced by bile duct ligation (BDL) rats. The histological section examination confirmed correspondence CT...
Abstract The effects of the obliteration portal venules (OPV) in cirrhotic hypertension are poorly understood. To investigate its contribution to biliary cirrhosis and underlying mechanism, we evaluated OPV using two‐dimensional (2D) histopathology liver explants from patients with atresia (BA, n = 63), primary cholangitis (PBC, 18), hepatitis B‐related (Hep‐B‐cirrhosis, 35). Then, three‐dimensional (3D) was measured by X‐ray phase‐contrast CT two parallel models rats following bile duct...
To evaluate the feasibility and efficiency of definitive concurrent chemoradiotherapy (dCRT) with S-1 cisplatin for elderly esophageal squamous cell carcinoma (ESCC) patients.Fifty-six patients were included from January 2012 to December 2014. Patients received (tegafur/gimeracil/oteracil) at doses 70 mg/m2/day two weeks 75 mg/m2 on day 1, respectively, every 3 weeks. Radiotherapy was delivered a dose 180-200 cGy per total 54 Gy. After dCRT, additional chemotherapy administered cycles.The...
Visualization of the microvascular network and thrombi in microvasculature is a key step to evaluating development tumor growth metastasis, influences treatment selection. X-ray phase-contrast computed tomography (PCCT) new imaging technique that can detect minute changes density reveal soft tissues discrimination at micrometer-scale resolution. In this study, six human resected hepatocellular carcinoma (HCC) were investigated with PCCT. A histological stain was added estimate accuracy The...
X-ray phase-contrast computed tomography (PCCT) can provide excellent image contrast for soft tissues with small density differences, and it is particularly appropriate three-dimensional (3D) visualization of accurate microstructures inside biological samples. In this study, the morphological structures proliferative bile ductules (BDs) were visualized without agents via PCCT liver fibrosis samples induced by duct ligation (BDL) in rats. Adult male Sprague-Dawley rats randomly divided into...
Abstract Bile infarct is a pivotal characteristic of obstructive biliary disease, but its evolution during the disease progression remains unclear. Our objective, therefore, to explore morphological alterations bile in course by means multiscale X-ray phase-contrast CT. duct ligation performed mice mimic disease. Intact liver lobes are scanned CT at various resolution scales. Phase-contrast clearly presents three-dimensional (3D) images infarcts down submicron level with good correlation...
Portal hypertension is one of the major complications cirrhosis. The changes in hepatic microvasculature are considered as critical pathophysiological characteristics portal hypertension. X-ray phase-contrast computed tomography (PCCT) a new imaging technique that can detect liver vessels at micrometric level without contrast agents.In this study, male Sprague-Dawley rats with cirrhosis induced by carbon tetrachloride (CCl4) or bile duct ligation (BDL) were investigated PCCT. pressures...
Propagation-based X-ray phase-contrast imaging (PBI) is a powerful nondestructive technique that can reveal the internal detailed structures in weakly absorbing samples. Extending PBI to CT (PBCT) enables high-resolution and high-contrast 3D visualization of microvasculature, which be used for understanding, diagnosis therapy diseases involving vasculopathy, such as cardiovascular disease, stroke tumor. However, long scan time PBCT impedes its wider use biomedical preclinical microvascular...
Abstract Propagation-based x-ray phase-contrast computed tomography (PB-PCCT) images often suffer from severe ring artifacts. Ring artifacts are mainly caused by the nonuniform response of detector elements, and they can degrade image quality affect subsequent processing quantitative analyses. To remove in PB-PCCT images, a novel method combined sparse-domain regularized stripe decomposition (SDRSD) with guided filtering (GIF) was proposed. In this method, polar coordinate transformation...
In-line X-ray phase-contrast computed tomography (IL-PCCT) can reveal fine inner structures for low- Z materials ( e.g. biological soft tissues), and shows high potential to become clinically applicable. Typically, IL-PCCT utilizes filtered back-projection (FBP) as the standard reconstruction algorithm. However, FBP algorithm requires a large amount of projection data, subsequently radiation dose is needed reconstruct high-quality image, which hampers its clinical application in IL-PCCT. In...
Hepatocellular carcinoma (HCC) is a cancer with poor prognosis, and approximately 80% of HCC cases develop from cirrhosis. Imaging techniques in the clinic seem to be insufficient for revealing microstructures liver disease. In recent years, phase contrast imaging CT (PCI-CT) has opened new avenues biomedical applications owing its unprecedented spatial resolution. The aim this study was present three-dimensional (3D) visualization human healthy liver, cirrhosis using PCI-CT technique called...
In-line X-ray phase-contrast computed tomography (IL-PCCT) is a valuable tool for revealing the internal detailed structures in weakly absorbing objects ( e.g. biological soft tissues), and has great potential to become clinically applicable. However, long scanning time IL-PCCT will result high radiation dose samples, thus impede wider use of clinical biomedical imaging. To alleviate this problem, new iterative CT reconstruction algorithm presented that aims decrease by reducing projection...
Propagation-based X-ray phase–contrast computed tomography (PB-PCCT) can serve as an effective tool for studying organ function and pathologies. However, it usually suffers from a high radiation dose due to the long scan time. To alleviate this problem, we propose deep learning reconstruction framework PB-PCCT with sparse-view projections. The consists of dual-path neural networks, where edge detection, guidance, artifact removal models are incorporated into two subnetworks. It is worth...
In-line X-ray phase-contrast computed tomography typically contains two independent procedures: phase retrieval and reconstruction, in which multi-material streak artifacts are important problems. To address these problems simultaneously, an accelerated 3D iterative image reconstruction algorithm is proposed. It merges the above-mentioned procedures into one step, establishes data fidelity term raw projection domain while introducing total variation regularization domain. Specifically, a...
BACKGROUND: Low-dose computed tomography (CT) has been successful in reducing radiation exposure for patients. However, the use of reconstructions from sparse angle sampling low-dose CT often leads to severe streak artifacts reconstructed images. OBJECTIVE: In order address this issue and preserve image edge details, study proposes an adaptive orthogonal directional total variation method with kernel regression. METHODS: The images are initially processed through regression obtain N-term...
Intrahepatic circulation is essential for the repair of acute liver injury (ALI); however, very limited information available concerning changes in circulatory pathways during ALI. Therefore, multi-scale X-ray phase-contrast CT combined with three-dimensional (3D) visualization used to quantitatively analyze intrahepatic pathway (including hepatic vein, portal vein and sinusoid) mouse model via intraperitoneal injection carbon tetrachloride (CCl4) from recovery. The results demonstrate that...
Synchrotron X-ray microtomography (S-µCT) is a highly valuable technique for investigating organ function and pathologies. However, its application often limited by high radiation doses the occurrence of ring artifacts. While S-µCT utilizing sparse-view projections can effectively decrease doses, reconstructed images frequently exhibit severe streaking artifacts, which are exacerbated ultimately compromising reconstruction accuracy, image quality, resolution. Previous research has primarily...
Abstract Gliomas are rich in blood vessels, and the generation of tumor‐associated vessels plays an important role glioma growth transfer. Histology can directly depict microvascular architecture tumor, but it just provides two‐dimensional (2D) images obtained by destroying three‐dimensional (3D) tissue specimens. There is a lack high‐resolution 3D imaging methods for observing microvasculature throughout entire X‐ray phase‐contrast computed tomography (PCCT) which emerging method has...