A5101905882- Single-cell and spatial transcriptomics
- Birth, Development, and Health
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Health, Environment, Cognitive Aging
- Advancements in Battery Materials
- MicroRNA in disease regulation
- Privacy-Preserving Technologies in Data
- Forensic Anthropology and Bioarchaeology Studies
- Genetics, Aging, and Longevity in Model Organisms
- Recommender Systems and Techniques
- Burn Injury Management and Outcomes
- Oil and Gas Production Techniques
- Advanced Data Processing Techniques
- Power Transformer Diagnostics and Insulation
- Dermatological and COVID-19 studies
- UAV Applications and Optimization
- Machine Fault Diagnosis Techniques
- Plant Disease Resistance and Genetics
- Circular RNAs in diseases
- Advances in Cucurbitaceae Research
- Mental Health via Writing
- Sex and Gender in Healthcare
Shanghai Advanced Research Institute
2021-2025
Chinese Academy of Sciences
2021-2025
Zhejiang University
2025
First Affiliated Hospital Zhejiang University
2025
Wuhan Institute of Technology
2024
Naval University of Engineering
2021-2024
University of Chinese Academy of Sciences
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Peking University
1992-2024
Liaoning Technical University
2023
Background: Impaired one-carbon metabolism is thought to be associated with the risk of neural tube defects (NTDs); however, role methylation in NTDs remains unclear. Long interspersed nucleotide element-1 (LINE-1) constitutes 17–25% human genome. LINE-1 hypomethylation correlates global DNA levels cancerous cells, but limited information available on NTDs. Objective: We determined whether patterns were development and possible relations between key maternal metabolites involved...
Abstract Reliable mechanical fault diagnosis of high-voltage circuit breakers is important to ensure the safety electric power systems. Recent approaches are mostly based on a single classifier whose performance relies heavily expert prior knowledge. In this study, we propose an improved Dempster–Shafer evidence theory fused echo state neural network, ensemble for diagnosis. Evidence credibility calculated through deviation matrix and segmented circle function employed as weights rectify raw...
A 37-year-old man presented with a 2-month history of fever unknown origin and erythema rashes on the trunk limbs. 18F-FDG PET/CT revealed increased uptake in subcutaneous panniculitis, forming snow leopard sign, along enlarged lymph nodes, which suggested panniculitis-like T-cell lymphoma. However, skin biopsy indicated infection, bone marrow no abnormal lymphocytes. After anti-infection treatment, symptoms improved, leading to final diagnosis systemic infection. This case demonstrates how...
<abstract abstract-type="Abstract"> Population aging has become a global concern in population development. Challenges to good health older ages are more complex than at any other age and require comprehensive framework move the science of forward. In this paper, we describe an advanced evolving conceptual that includes definitions, goals, disciplines, scope human omics (HAO) based on theories methods science. The development HAO will bring paradigm shift research related by systematic...
Fast-developing single-cell technologies create unprecedented opportunities to reveal cell heterogeneity and diversity. Accurate classification of single cells is a critical prerequisite for recovering the mechanisms heterogeneity. However, scRNA-seq profiles we obtained at present have high dimensionality, sparsity, noise, which pose challenges existing clustering methods in grouping that belong same subpopulation based on transcriptomic profiles. Although many computational been proposed...
Single cell technologies provide an unprecedented opportunity to explore the heterogeneity in a biological process at level of single cells. One major challenge analyzing data is identify subpopulations, stable states, and cells transition between states. To elucidate mechanisms fate dynamics, it highly desirable quantitatively characterize cellular states intermediate Here, we present scRCMF, unsupervised method that identifies by adopting nonlinear optimization model infers latent...
3D printing, also known as additive manufacturing, has emerged a promising strategy to design and fabricate future energy storage devices. Although significant progress been reported, current printed battery designs are still limited by the choice of electrolyte, such ceramic or conventional toxic organic electrolytes. Here, we incorporated latest developments in aqueous batteries into novel printable that can be fabricated directly an ambient environment is more environmentally friendly....
<abstract> <p>In recent years, the coverage path planning (CPP) of unmanned aerial vehicles (UAVs) has attracted attention in reconnaissance, patrol, and search rescue efforts, aiming to plan paths for UAVs cover a specified area as efficiently possible. This paper proposes UAV fast model prioritize important targets with domain composition based on starting point location targets, combined decomposition strategy targets. Considering constraints number UAVs, operators, flight...
With the successful application of single-cell sequencing technology, a large number multi-omics (scMO-seq)data have been generated, which enables researchers to study heterogeneity between individual cells. One prominent problem in data analysis is prevalence dropouts, caused by failures amplification during experiments. It necessary develop effective approaches for imputing missing values. Different with general methods single type data, we propose an imputation method called scLRTD, using...
Edge devices employing federated learning encounter several obstacles, including (1) the non-independent and identically distributed (Non-IID) nature of client data, (2) limitations due to communication bottlenecks, (3) constraints on computational resources. To surmount Non-IID data challenge, personalized has been introduced, which involves training tailored networks at edge; nevertheless, these methods often exhibit inconsistency in performance. In response concerns, a novel framework for...
Abstract Single-cell RNA sequencing (scRNA-seq) technology is one of the most cost-effective and efficacious methods for revealing cellular heterogeneity diversity. Precise identification cell types essential establishing a robust foundation downstream analyses prerequisite understanding heterogeneous mechanisms. However, accuracy existing warrants improvement, highly accurate often impose stringent equipment requirements. Moreover, unsupervised learning-based approaches are constrained by...
Meiosis is a complex process involving the expression and interaction of numerous genes in series highly orchestrated molecular events. Fam9b localized Xp22.3 has been found to be expressed testes. However, FAM9B expression, localization, its role meiosis have not previously reported. In this study, was evaluated human testes ovaries by RT-PCR, qPCR, western blotting. nuclei primary spermatocytes specifically synaptonemal (SC) region spermatocytes. also evident follicle cell diffusely...