A5072249264- Nutrition and Health in Aging
- Cancer survivorship and care
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Childhood Cancer Survivors' Quality of Life
- Head and Neck Cancer Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Treatment and Pharmacology
- Vitamin C and Antioxidants Research
- Palliative Care and End-of-Life Issues
- GDF15 and Related Biomarkers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and exercise physiology
- Nuclear Structure and Function
- Physical Activity and Health
- Lung Cancer Treatments and Mutations
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Economic and Financial Impacts of Cancer
- Cancer-related cognitive impairment studies
- Management of metastatic bone disease
- Chemotherapy-related skin toxicity
- Chemotherapy-induced cardiotoxicity and mitigation
- Cerebral Palsy and Movement Disorders
- Hematological disorders and diagnostics
- Colorectal Cancer Treatments and Studies
Norwegian University of Science and Technology
2014-2024
University of Bergen
2023-2024
St Olav's University Hospital
2014-2022
European Association for Palliative Care
2014
Abstract Background Cancer cachexia is a syndrome of weight loss (including muscle and fat), anorexia, decreased physical function. It has been suggested that the optimal treatment for should be multimodal intervention. The primary aim this study was to examine feasibility safety intervention (n‐3 polyunsaturated fatty acid nutritional supplements, exercise, anti‐inflammatory medication: celecoxib) cancer in patients with incurable lung or pancreatic cancer, undergoing chemotherapy. Methods...
Background. Sarcopenia is a defining feature of cancer cachexia associated with physical decline, poor quality life and prognosis. Thus, maintaining muscle mass an important aim treatment. Many patients at risk for developing or experience side effects chemotherapy that might aggravate the development cachexia. However, achieving tumor control reverse catabolic processes causing There limited knowledge about changes during whether in are response to chemotherapy.Patients methods. In this...
Background. How to assess cachexia is a barrier both in research and clinical practice. This study examines the need for assessing reduced food intake loss of appetite, see if these variables can be used interchangeably. A secondary aim variance explained by intake, appetite weight using tumor-related factors, symptoms biological markers as explanatory variables. Material methods. One thousand seventy patients with incurable cancer were registered an observational, cross sectional...
BACKGROUND Patients with head and neck cancer (HNC) experience involuntary weight loss that has a negative impact on physical function, morbidity, survival. The objective of the current study was to evaluate feasibility an exercise nutrition intervention during radiotherapy (RT) compared after RT, examine preliminary effects skeletal muscle mass. METHODS HNC were randomized RT (EN‐DUR) or (EN‐AF). EN‐DUR conducted at hospital EN‐AF took place rehabilitation center. interventions consisted...
LBA12007 Background: Cancer cachexia arises from the interaction between host and tumour, triggering an inflammatory response that leads to weight appetite loss, diminished physical activity, reduced treatment efficacy survival. Combining interventions address inflammation, activity is proposed as effective strategy. Building on a promising pilot study, we conducted MENAC (Multimodal Exercise Nutrition Anti-inflammatory Cachexia) trial comprehensively evaluate this approach in patients with...
Disability related to incurable cancer affects over a million Europeans each year and people with rank loss of function among the most common unmet supportive care needs.To test clinical cost-effectiveness an integrated short-term palliative rehabilitation intervention, optimise quality life in affected by cancer.This is multinational, parallel group, randomised, controlled, assessor blind, superiority trial.The INSPIRE consortium brings together leaders care, oncology from partner...
Background: Muscle mass and physical function (PF) are common co-primary endpoints in cancer cachexia trials, but there is a lack of data on how these outcomes interact over time. The aim this secondary analysis from trial investigating multimodal intervention for (ClinicalTrials.gov: NCT01419145) to explore whether changes muscle PF associated with weight loss status at baseline. Methods: Secondary was conducted using phase II randomized controlled including 46 patients stage III–IV...
Cachexia is a multifactorial syndrome that common in cancer and chronic disease. It often underdiagnosed therefore goes untreated or undertreated. causes suffering across biopsychosocial domains affects patients their loved ones. In this article, group of clinicians researchers care, nutrition, exercise offers tips about assessment, classification, management cachexia, with attention to its stage. The required multimodal cachexia mirrors well the interprofessional collaboration mainstay...
9628 Background: The pathophysiology of cancer cachexia is multi-factorial consisting muscle wasting, negative protein and energy balance, systemic inflammation. There no established treatment for cachexia, paradoxical to the importance this condition in limiting oncology treatment. New approaches are needed address complexity syndrome challenge accepted therapeutic nihilism. To treat optimally it has been argued that a multimodal intervention necessary enable multi factorial be targeted....
Background: New clinical trials in cancer cachexia are essential, and outcome measures with high responsiveness to detect meaningful changes crucial. This secondary analysis from a multimodal intervention trial estimates sensitivity change between treatment effect sizes (ESs) of associated body composition, physical function, metabolism, intervention. Methods: The study was multicenter, open-label, randomized pilot investigating the feasibility 6-week [exercise, non-steroidal...
Abstract Background Colorectal cancer (CRC) is the third most common worldwide, and a large proportion of patients receive adjuvant oxaliplatin-based chemotherapy. Most these experience chemotherapy-induced peripheral neuropathy (CIPN), affecting quality life. Evidence to advise exercise reduce CIPN limited. The primary aim this study was investigate feasibility an intervention data collection among CRC during Material methods This non-randomized included admitted chemotherapy consisting...
SummaryBackground & aimsThe aim of this study was to test how well the Patient-Generated Subjective Global Assessment (PG-SGA) question about food intake correlates with a well-established measurement intake. Furthermore, we wanted examine if there were any associations between patients ratings and weight change.MethodsData at baseline after 4–6 weeks drawn from two studies which combined provided sample 85 lung pancreatic cancer; one an intervention study, other prospective, observational...
Abstract Background Incurable cancer is a major contributor to societal suffering and disability, palliative rehabilitation recommended be integrated within between services at all healthcare levels. However, little knowledge exists on how integration of in understood achieved clinical practice. INSPIRE (Integrated short-term improve quality life equitable care access incurable cancer) large European-funded project that aims promote through novel model for people disabled by advanced cancer....
Background Many cancer survivors experience late effects of treatment and therefore struggle to return work. Norway provides rehabilitation programs increase labor force participation for after treatment. However, the extent which such affect has not been appropriately assessed. This study aims investigate i) participation, sick leave disability rates among up 10 years being diagnosed with identify comorbidities contributing long-term or pensioning; ii) how type cancer, modalities,...
9562 Background: Physicians might overestimate benefits and underestimate toxicity of cancer therapy. Thus, patient reported HRQoL is an important part evaluating treatment effect assessing side effects. commonly once per chemotherapy cycle just prior to administration the next course (day 0). Several studies have not detected differences in despite physician-observed toxicity. We hypothesized that varies during cycles; effects are most pronounced first week after administration; repeated...