A5003095039- Plant Molecular Biology Research
- Plant Reproductive Biology
- Plant and Biological Electrophysiology Studies
- Fern and Epiphyte Biology
- Light effects on plants
- Photosynthetic Processes and Mechanisms
- Plant tissue culture and regeneration
- Plant Diversity and Evolution
- Plant nutrient uptake and metabolism
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Advanced machining processes and optimization
- Plant Parasitism and Resistance
- Advanced Surface Polishing Techniques
- Tribology and Lubrication Engineering
- Plant Stress Responses and Tolerance
- Metal and Thin Film Mechanics
- Cancer-related gene regulation
- Glioma Diagnosis and Treatment
- Plant Gene Expression Analysis
- Radiopharmaceutical Chemistry and Applications
- Polysaccharides and Plant Cell Walls
- Plant-Microbe Interactions and Immunity
- Plant Genetic and Mutation Studies
- Adhesion, Friction, and Surface Interactions
Purdue University West Lafayette
1994-2025
Plant (United States)
2024
Chongqing Medical University
2024
Dalian Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Zhejiang Science and Technology Information Institute
2023
Jiangsu University
2019-2022
State Street (United States)
2021
Institute of Genetics and Developmental Biology
2020
Chinese Academy of Sciences
2020
Abstract Seed development in Arabidopsis thaliana undergoes an initial phase of endosperm proliferation followed by a second which the embryo grows at expense endosperm. As mature seed size is largely attained during phase, coordinately determined growth maternal ovule, endosperm, and embryo. Here, we identify SHORT HYPOCOTYL UNDER BLUE1 (SHB1) as positive regulator that affects both cell number. shb1-D, gain-of-function overexpression allele, increases size, shb1, loss-of-function reduces...
Enough but not too many stem cells In the shoot apical meristem of plants, just right number generates a steady supply with which to build differentiated tissues. Too few cells, and plant cannot grow. many, growth runs amok. Zhou et al. analyzed controls on cell proliferation. They found that HAIRY MERISTEM proteins define domain within WUSCHEL (WUS) work, beyond WUS is left free promote Science , this issue p. 502
The CLAVATA3 (CLV3)-CLAVATA1 (CLV1) ligand-receptor kinase pair negatively regulates shoot stem cell proliferation in plants. clv1 null mutants are weaker phenotype than clv3 mutants, but the is enhanced by mutations related receptor kinases BARELY ANY MERISTEM 1, 2 and 3 (BAM1, 3). basis of this genetic redundancy unknown. Here, we demonstrate that apparent CLV1 clade fact due to transcriptional repression BAM genes signaling. signaling rib meristem (RM) apical necessary sufficient for...
Abstract Plant inflorescence meristems and floral possess specific boundary domains that result in proper organ separation specification. HANABA TARANU (HAN) encodes a boundary-expressed GATA3-type transcription factor regulates shoot meristem organization flower development Arabidopsis thaliana, but the underlying mechanism remains unclear. Through time-course microarray analyses following transient overexpression of HAN, we found HAN represses hundreds genes, especially genes involved...
CDK8 is a key subunit of Mediator complex, large multiprotein complex that fundamental part the conserved eukaryotic transcriptional machinery. However, biological functions in plant abiotic stress responses remain largely unexplored. Here, we demonstrated as critical regulator abscisic acid (ABA) signaling and drought response pathways Arabidopsis. Compared to wild-type, cdk8 mutants showed reduced sensitivity ABA, impaired stomatal apertures hypersensitivity stress. Transcriptomic...
LEAFY stimulates auxin signaling but inhibits biosynthesis in developing flowers.
Abstract In multicellular organisms, a long-standing question is how spatial patterns of distinct cell types are initiated and maintained during continuous division proliferation. Along the vertical axis plant shoot apical meristems (SAMs), stem cells located at top while specifying more basally, forming robust apical-basal pattern. We previously found that in Arabidopsis SAMs, HAIRY MERISTEM (HAM) family transcription factors form concentration gradient from epidermis to interior layers,...
Seed development in Arabidopsis and many dicots involves an early proliferation of the endosperm to form a large embryo sac or seed cavity close size mature seed, followed by second phase during which grows replaces endosperm. Short hypocotyl under BLUE1 (SHB1) is member SYG1 protein family fungi, Caenorhabditis elegans, flies, mammals. SHB1 gain-of-function enhances proliferation, increases size, up-regulates expression WRKY transcription factor gene MINISEED3 (MINI3) LRR receptor kinase...
Background: As a ubiquitous environmental pollutant, methylmercury (MeHg) induces toxic effects in the nervous system, one of its main targets. However, exact mechanisms neurotoxicity have not been fully elucidated. Hypoxia-inducible factor-1α (HIF-1α), transcription factor, plays crucial role adaptive and cytoprotective responses cells is involved cell survival, proliferation, apoptosis, inflammation, angiogenesis, glucose metabolism, erythropoiesis, other physiological activities....
Abstract Fern gametophytes are autotrophic and independent of sporophytes, they develop pluripotent meristems that drive prothallus development sexual reproduction. To reveal cellular dynamics during meristem in fern gametophytes, we performed long-term time-lapse imaging determined the real-time lineage, identity division activity each single cell from initiation to establishment Ceratopteris richardii . Our results demonstrate only a few lineages originated marginal layer contribute...
Land plants alternate between asexual sporophytes and sexual gametophytes. Unlike seed plants, ferns develop free-living Gametophytes of the model fern Ceratopteris exhibit two sex types: hermaphrodites with pluripotent meristems males lacking meristems. In absence pheromone antheridiogen, convert to by forming de novo meristems, though mechanisms remain unclear. Using long-term time-lapse imaging computational analyses, we captured male-to-hermaphrodite conversion at single-cell resolution...
Protein degradation orchestrated by SKP1·CUL1·F-box protein (SCF) ubiquitin ligases is a fundamental process essential for cellular and organismal function. The dynamic assembly of SCFs, facilitated CAND1, ensures timely ubiquitination diverse SCF target proteins. As homolog CAND2 alone has been implicated in various human diseases, yet its functional mechanisms remain elusive. Here, we investigate the role cells distinct mode action compared to CAND1. Using an array quantitative assays,...
✓ The bradykinin analog, RMP-7, was investigated for its ability to increase selectively the transport of 68 Ga ethylenediamine tetraacetic acid (EDTA) into recurrent malignant gliomas in nine patients. For each patient, two positron emission tomography (PET) studies (one with and one without RMP-7) were performed. 10 300 ng/kg compound infused supraophthalmic carotid artery over 15 minutes. In PET study, a sequence scans initiated simultaneously an intravenous bolus EDTA (5–10 mCi)....
As the closest extant sister group to seed plants, ferns are an important reference point study origin and evolution of plant genes traits. One bottleneck use in phylogenetic genetic studies is fact that genome-level sequence information this limited, due extreme genome sizes most ferns. Ceratopteris richardii (hereafter Ceratopteris) has been widely used as a model system for In study, we generated transcriptome Ceratopteris, through de novo assembly RNA-seq data from 17 sequencing...
In Arabidopsis shoot apical meristems (SAMs), a well-characterized regulatory loop between WUSCHEL (WUS) and CLAVATA3 (CLV3) maintains stem cell homeostasis by regulating the balance proliferation differentiation. WUS proteins, translated in deep layers, move into overlaying cells to activate CLV3. The secreted peptide CLV3 then regulates levels through ligand-receptor mediated signaling cascade. is specifically expressed repressed layers despite presence of activator, forming an...
SUMMARY The shoot apical meristems (SAMs) of land plants are crucial for plant growth and organ formation. In several angiosperms, the HAIRY MERISTEM ( HAM ) genes function as key regulators that control meristem development stem cell homeostasis. To date, origin evolutionary history family in remains unclear. Potentially shared divergent functions members from angiosperms non‐angiosperms also not known. constructing a comprehensive phylogeny family, we show proteins widely present...
Abstract The alternation of generations in land plants occurs between the sporophyte phase and gametophyte phase. sporophytes seed develop self-maintained, multicellular meristems, these meristems determine plant architecture. gametophytes lack are heterotrophic. In contrast, seed-free vascular plants, including ferns, autotrophic free-living, developing to sustain their independent growth proliferation. Compared with cellular mechanisms underlying meristem development fern remain largely...