Various triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings (3-6) were synthesized screened for their antioxidant activities. The structures of the (2-6) judged by (1)H NMR, (13)C elemental analysis, LC-MS spectral data. Antioxidant activities determined with CUPric Reducing Capacity (CUPRAC), ABTS (2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)/persulfate, DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. Most showed a significant activity especially,...

A practical protocol has been used for the synthesis of benzimidazoles. The reaction iminoester hydrochlorides phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to benzimidazole derivatives good yields and in short times. After benzimidazoles, we synthesized ester hydrazide yields. All compounds were evaluated regard pancreatic lipase activity 3b, 3c, 5a 6a showed inhibition at various concentrations.

A series of new 1,2,4‐triazole‐3‐one derivatives bearing the salicyl moiety were synthesized by using microwave irradiation, and their chemical structures identified IR, 1 H NMR, 13 C elemental analysis, LC‐MS. The anticonvulsant activities compounds 4a – c , 4e 5a e evaluated Anticonvulsant Screening Program National Institute Health, USA. had moderate in maximum electroshock‐induced seizure minimal clonic models mice, without any neurotoxic effects.

A new series of 2-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole derivatives containing a 1,2,4-triazole ring were synthesized via microwave technique. This efficient procedure provides pure products within few minutes. The newly compounds confirmed by (1) H NMR and (13) C spectra they screened for their lipase inhibition antioxidant activities. Compounds 4a, 4b, 5a, 5b showed very good scavenging activity.

In the present study, 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide (1) was used as starting compound for synthesis of 2-{[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetyl}-4-thiosemicarbazides (2a–c) and 5-{[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]methyl}-1,3,4-oxadiazole-2-thione (5). The cyclization compounds 2a–c in presence NaOH resulted formation...

4‐Bromo‐ o ‐phenylenediamine and ethylimido‐ p ‐bromophenylacetate, 1 , were subjected to microwave irradiation synthesize benzimidazole derivative, compound 2 . Ester 3 hydrazide 4 of also synthesized, respectively. Finally, was treated with 11 different aromatic aldehydes obtain derivatives containing imine function. All reactions carried out conventional heating, results compared. Some the newly synthesized compounds showed moderate antimicrobial activity against some tested organisms.

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An easy efficient method for the synthesis of N-(3,5-dichlorophenyl)-5-alkyl/aryl-3H-1,2,4-triazol-3-one derivatives under microwave irradiation has been developed using reaction 3,5-dichloroaniline and ethoxycarbonylhydrazones. This occurs more efficiently faster than conventional heating method. We obtained 5-mercapto-1,3,4-oxadiazol by this The newly synthesised compounds have tested their antimicrobial activity against Enterobacter cloaceae, Escherichia coli, Klebsiella pneumonie,...

Abstract A new series of 5,6‐dimethyl‐2‐phenyl‐1 H ‐benzimidazole derivatives was synthesized. The antioxidant activities the synthesized compounds were determined according to cupric reducing capacity (CUPRAC), ABTS, and DPPH assays. Many target showed good activity. Among these compounds, it has been that carbothioamide 1,2,4‐triazole had a very capacity. Also, all screened for in vitro inhibitory activity against Jack bean urease. molecules, starting compound, acetate, acetohydrazide...

Abstract A novel series of N ′‐(2‐(3,5‐disubstituted‐4 H ‐1,2,4‐triazol‐4‐yl)acetyl)‐6/7/8‐substituted‐2‐oxo‐2 ‐chromen‐3‐carbohydrazides were synthesized and studied for their α‐glucosidase inhibition activity. Most the compounds exhibited potential activity with IC 50 values ranging from 0.96 ± 0.02 to 32.86 0.73 µg/ml. Among them, 3e 4e , having a methoxy group on coumarin ring, proved be most potent ones, showing an enzyme = 1.44 0.06 µg/ml, respectively. The kinetic study through...

Abstract In the present investigation, key intermediate acetohydrazide derivative 5 was synthesized starting from 3-(4-methoxybenzyl)-4-amino-4,5-dihydro-1,2,4-triazol-5-one (1) by a four-step reaction. Thiosemicarbazides 6a-f and arylidenehydrazide derivatives 8a-d were obtained compound 5. The cyclization of compounds in presence NaOH resulted formation 7a-f. characterized IR, 1 H NMR, 13 C NMR spectroscopy, elemental analysis mass spectral studies. tested for their anti-lipase,...

Microwave irradiation has been used to accelerate the conversion of isatin (1a) and 5-nitroisatin (1b) into their Schiff bases 3-[5 ’-aryl(alkyl)-2 ’,4 ’-dihydro-1 ’,2 ’-triazol-3 ’-on-4 ’-yl]iminoisatin (3a–g) ’-yl]imino-5-nitroisatin (4a–g), respectively. Reaction was achieved by microwave-induced technique, which reduced reaction time drastically improved yield when compared conventional heating. The newly synthesised showed moderate antimicrobial activity against standard bacterial...

2,2'-[1,4 (1,3)-Phenylenedi(methylene)]bis-1H-benzimidazole derivatives were obtained from the reaction of 1,4- or (1,3)-bisiminoester hydrochloride and o-phenylenediamine under microwave irradiation. Ester hydrazide prepared a free NH group. This practical method revealed good results for yield, time, quick isolation products.