Abstract This work explores the application of Allium sativum (Garlic) extract, in creation novel polymeric core‐sheath fibers for wound therapy applications. The pressurized gyration (CS PG) technology is utilized to mass‐produce with a polycaprolactone (PCL) core and polyethylene oxide (PEO) sheath, loaded garlic extract. produced maintain structural integrity, long‐term stability provide cell‐friendly surface rapid antibacterial activity. physical properties, morphology, therapeutic...

Propolis, a natural bee product, has both antimicrobial/antifungal and antioxidant characteristics. Active substances having antimicrobial antifungal effects are used to avoid infections, which develop during long treatment process of chronic wounds. Antioxidant protect wound areas against the effect free radicals accelerate healing process. For this purpose, propolis was topical liposome formulations for treatment. Characterization studies (particle size distribution, polydispersity index,...

Microbial biofilms are a serious threat to human health. Recent studies have indicated that many clinically relevant polymicrobial. In the present study, multispecies were grown in reproducible manner 96-well microtiter plate. The efficacy of nine commercially available disinfectants against Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa was determined compared. results showed direction magnitude effect biofilm depend on strain disinfectant used challenge common belief...

Acne vulgaris is one of the most common chronic diseases worldwide with high prevalence ratio about 80–85% in patients who are puberty period. For treatment options, many conventional dosage forms available; however, existing limitations systemic administration drugs (oral antibiotics), such as adverse events and resistance, led for seek new formulation options. In this study, liposomes containing tetracycline HCl tretinoin were prepared by film formation method. vitro characterization...

In recent years, drug delivery systems such as liposomes and microparticles have been used in clinic for the treatment of different diseases from a regulatory point view, parenterally applied must be sterile pyrogen free. Radiation sterilization is method recognized by pharmacopoeias to achieve sterility criteria parenterals. It has ability kill microorganisms therapeutic products. The of, however, irradiation might also affect performance systems. One most critical points dose, because...

Abstract Fibrous constructs with incorporated cinnamon‐extract have previously been shown to potent antifungal abilities. The question remains whether these are useful in the prevention of bacterial infections fiber form and what antimicrobial effects means terms toxicity native physiological cells. In this work, cinnamon extract containing poly (ε‐caprolactone) (PCL) fibers were successfully manufactured by pressurized gyration had an average size ∼2 μm. Cinnamon PCL tested against...

Abstract A series of compounds derived from 4,5‐dihydro‐1 H ‐1,2,4‐triazol‐5‐one were synthesized and characterized by spectral data. The 12 new analyzed for their potential in vitro antioxidant activities three different methods. Compound 4f showed the best activity iron binding. In addition, 4 titrated potentiometrically with tetrabutylammonium hydroxide non‐aqueous solvents. RP‐HPLC capacity factors ( k ′) also determined on a C18 column, methanol/water as mobile phase. correlation...

Biomaterial-associated infections are a major cause of biomaterial implant failure. To prevent the initial attachment bacteria to surface, researchers have investigated various surface modification methods. However, most these approaches also attachment, spread, and growth mammalian cells, resulting in tissue integration Therefore, success implants requires an optimal balance between (cell adhesion implants) inhibition bacterial colonization. In this regard, we synthesize bifunctional...

Background: Enterococcus faecalis, Escherichia coli, Staphylococcus epidermidis, Pseudomonas aeruginosa and Candida albicans biofilms are major causes of catheter-associated urinary tract infections.Antimicrobial-coated or impregnated catheters seen as a possible way to prevent these infections.Aims: To determine the biofilm-forming ability 89 E. faecalis isolates from infections compare several for antimicrobial durability inhibitory effects on biofilm formation different laboratory strains...

Introduction: Alternative anti-biofilm agents are needed to combat Pseudomonas aeruginosa infections. The mechanisms behind these new also need be revealed at a molecular level. Materials and methods: effects of 10 plant-derived compounds on P. biofilms were investigated using minimum biofilm eradication concentration (MBEC) virulence assays. ciprofloxacin compound combinations in mono triple compared. A metabolomic approach qRT-PCR applied the treated with combination baicalein, esculin...

This study reports the synthesis and evaluation of a series new pyridazin-3-ones with furan moieties 5a-j 6a-f, to test for their antimycobacterial antifungal activities. The structures target compounds were confirmed by elemental analysis spectroscopic techniques (IR, mass, 1H- 13C- NMR). Amongst tested, 5e, 5g, 5i 6e exhibited highest activity against Mycobacterium tuberculosis, while 5h, 6d 6f showed moderate in vitro activities C. albicans parapsilosis.

Abstract Azole antifungal drugs are commonly used in chemotherapy. Antibacterial effects of some topical antifungals, such as miconazole and econazole, have lately been revealed, which suggests a promising venue antimicrobial In this study, we tested an in‐house azole collection with properties for their antibacterial activity to identify dual‐acting hits using the broth microdilution method. The vitro screen yielded number potent derivatives against gram‐positive bacteria, Enterococcus...

A novel chemical metabolomics tool for quantification of short-chain fatty acids in bacterial cultures that is compatible with global analysis due to the use a limited sample volume.

Abstract Fungal infections have become a major public health issue with dramatically increasing morbidity, mortality and cost of hospitalization. Azole antifungals are first‐in‐line medications against most types mycoses azoles having an oxime moiety, although not extensively investigated, were reported to great antifungal potential, as well as, activity Gram‐positive bacteria. In the current study, new series 2‐(1 H ‐imidazol‐1‐yl)‐1‐phenylethanone esters ( 5 – l ) synthesized tested for...

The objective of the present study was to investigate reduction in colonization and growth heterotrophic bacteria dental unit waterlines by using hydrogen peroxide/colloidal silver as disinfectant. Twenty-seven units were included; 6 that more than 20 years old 7 had been use for 2 comprised new treatment groups, respectively. Fourteen served controls. groups disinfected continuously every 4 weeks shock doses applied over a 20-week period. Water samples taken before treatment, 1 after...

Systemic candidiasis is a major health issue for immunocompromised individuals due to the increase in drug-resistance among Candida spp., which are prevalent pathogenic fungi responsible many types of fungal infections.Azoles most preferred antifungal class systemic with broad spectrum and availability.In this study, we synthesized tested effects two new indole derivatives investigate impact on activity azole compounds find potent against spp.including resistant strains...

Abstract Systemic Candida infections pose a serious public health problem with high morbidity and mortality. C. albicans is the major pathogen identified in candidiasis; however, non‐ spp. antifungal resistance are now more prevalent. Azoles first‐choice drugs for they ineffective certain caused by resistant strains. block ergosterol synthesis inhibiting fungal CYP 51, which leads to disruption of membrane permeability. In this study, we screened activity an in‐house azole library 65...