A5022828802- Antifungal resistance and susceptibility
- Fatigue and fracture mechanics
- Fungal and yeast genetics research
- Genomics and Chromatin Dynamics
- Fungal Infections and Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Asthma and respiratory diseases
- Hemoglobin structure and function
- Spaceflight effects on biology
- Microtubule and mitosis dynamics
- Nematode management and characterization studies
- Microbial Natural Products and Biosynthesis
- interferon and immune responses
- Probabilistic and Robust Engineering Design
- Microbial infections and disease research
- Reliability and Maintenance Optimization
- Plant Pathogens and Fungal Diseases
- Mycotoxins in Agriculture and Food
- Infectious Diseases and Mycology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Protist diversity and phylogeny
- Viral Infections and Immunology Research
- Wnt/β-catenin signaling in development and cancer
- Risk and Safety Analysis
Dartmouth College
2017-2023
ScienceSouth
2022
Boeing (Australia)
2011
Cell size control requires mechanisms that link cell growth with Cdk1 activity. In fission yeast, the protein kinase Cdr2 forms cortical nodes include inhibitor Wee1 along Wee1-inhibitory Cdr1. We investigated how inhibit during growth. Biochemical fractionation revealed were megadalton structures enriched for activated Cdr2, which increases in level interphase live-cell total internal reflection fluorescence microscopy videos, and Cdr1 remained constant at over time, but localized to short...
Aspergillus fumigatus is a human fungal pathogen that most often avirulent in immunecompetent individuals because the innate immune system efficient at eliminating conidia. However, recent clinical observations have shown severe influenza A virus (IAV) infection can lead to secondary A. infections with high mortality. Little currently known about how IAV alters antifungal response. Here, we established murine model of IAV-induced (IAV-
Abstract RIG-I–like receptors (RLR) are cytosolic RNA sensors that signal through the MAVS adaptor to activate IFN responses against viruses. Whether RLR family has broader effects on host immunity other pathogen families remains be fully explored. In this study, we demonstrate MDA5/MAVS signaling was essential for resistance pulmonary Aspergillus fumigatus challenge regulation of antifungal leukocyte in mice. Activation driven by dsRNA from live A. serving as a key vitality-sensing pattern...
is a filamentous fungus which can cause multiple diseases in humans. Allergic broncho-pulmonary aspergillosis (ABPA) disease diagnosed primarily cystic fibrosis patients caused by severe allergic response often to long-term
can cause a life-threatening infection known as invasive pulmonary aspergillosis (IPA), which is marked by fungus-attributable mortality rates of 20%-30%. Individuals at risk for IPA harbor genetic mutations or incur pharmacologic defects that impair myeloid cell numbers and/or function, exemplified bone marrow transplant recipients, patients receive corticosteroid therapy, with chronic granulomatous disease (CGD). However, treatments
Abstract Cell size control requires mechanisms that link cell growth with Cdk1 activity. In fission yeast, the protein kinase Cdr2 forms cortical nodes include inhibitor Wee1, along Wee1-inhibitory Cdr1. We investigated how inhibit Wee1 during growth. Biochemical fractionation revealed were megadalton structures enriched for activated Cdr2, which increases in level interphase live-cell TIRF movies, and Cdr1 remained constant at over time, but localized to short bursts. Recruitment of...
ABSTRACT Aspergillus fumigatus is a filamentous fungus which can cause multiple diseases in humans. Allergic Broncho-pulmonary Aspergillosis (ABPA) disease diagnosed primarily Cystic Fibrosis patients caused by severe allergic response often to long-term A. colonization the lungs. Mice develop an repeated inhalation of spores; however, no strains have been identified that survive mouse lung and ABPA-like disease. We characterized strain W72310 whole genome sequencing vitro vivo viability...
ABSTRACT Aspergillus fumigatus is a human fungal pathogen that most often avirulent in immune competent individuals because the innate system efficient at eliminating conidia. However, recent clinical observations have shown severe Influenza A virus (IAV) infection can lead to secondary A. infections with high mortality. Little currently known about how IAV alters antifungal response. Here, we established murine model of IAV-induced (IAV-Af) superinfection by inoculating mice followed 6 days...
Invasive pulmonary aspergillosis (IPA) is a life-threatening infection caused by species in the ubiquitous fungal genus Aspergillus . While leukocyte-generated reactive oxygen (ROS) are critical for clearance of conidia from lung and resistance to IPA, processes that govern ROS-dependent cell death remain poorly defined. Using flow cytometric approach monitors two independent markers, an endogenous histone H2A:mRFP nuclear integrity reporter Sytox Blue impermeable (live/dead) stain, we...
The aircraft industry around the globe is currently focusing on applying physical modelbased probabilistic analyses to assess quantitative risk for structural integrity. In particular, USAF has established risk/reliability based requirements in Aircraft Structural Integrity Program (ASIP) MIL-STD-1530C. advantages of Reliability-Based Analysis (RBA) over deterministic approaches are well recognized, such as reducing over– conservatism imposed by using safety factors, identifying optimal...