A5030590891- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Fungal and yeast genetics research
- Fungal Biology and Applications
- Bacterial biofilms and quorum sensing
- Plant-Microbe Interactions and Immunity
- Asthma and respiratory diseases
- Heat shock proteins research
- Mycorrhizal Fungi and Plant Interactions
- Plant Pathogens and Fungal Diseases
- Probiotics and Fermented Foods
- Nematode management and characterization studies
- Computational Drug Discovery Methods
- Entomopathogenic Microorganisms in Pest Control
- thermodynamics and calorimetric analyses
- Hemoglobin structure and function
- Spaceflight effects on biology
- Mycotoxins in Agriculture and Food
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Protist diversity and phylogeny
- Peptidase Inhibition and Analysis
- Infectious Diseases and Mycology
Cornell University
2023
Plant (United States)
2023
Dartmouth College
2019-2022
University of Minnesota
2020
ABSTRACT Cells must sense and respond to available nutrients utilize resources establish fungal colonies. Saprophytic microbes harvest carbon from plant biomass, which contains insoluble, complex carbohydrates that be degraded extracellularly prior import into the cell. Filamentous fungi can degrade these carbohydrates. However, while many single cellular building blocks of insoluble polysaccharides, they frequently are unable Cellobiose is a disaccharide breakdown product cellulose, most...
The mold Aspergillus fumigatus reproduces by the production of airborne spores (conidia), a process termed conidiation. In immunocompromised individuals, inhaled A. conidia can germinate and form filaments that penetrate damage lung tissues; however, conidiation does not occur during invasive infection. this study, we demonstrate forced activation in arrest their growth impair ability fungus to cause disease both an insect mouse model Activation was linked profound changes metabolism,...
The initiation of Aspergillus fumigatus infection occurs via dormant conidia deposition into the airways. Therefore, conidial germination and subsequent hyphal extension growth occur in a sustained heat shock (HS) environment promoted by host. cell wall integrity pathway (CWIP) essential eukaryotic chaperone Hsp90 are critical for fungi to survive HS. Although A. is thermophilic fungus, mechanisms underpinning HS response not thoroughly described important define its role pathogenesis,...
Regulation of fungal cell wall biosynthesis is critical to maintain integrity in dynamic infection microenvironments. Genes involved this response that impact fitness and host immune responses remain be fully defined. In study, we observed a yeast
Alanine metabolism has been suggested as an adaptation strategy to oxygen limitation in organisms ranging from plants mammals. Within the pulmonary infection microenvironment, Aspergillus fumigatus forms biofilms with steep gradients defined by regions of limitation. An alanine aminotransferase, AlaA, was observed function catabolism and is required for several aspects A. biofilm physiology. Loss
is a filamentous fungus which can cause multiple diseases in humans. Allergic broncho-pulmonary aspergillosis (ABPA) disease diagnosed primarily cystic fibrosis patients caused by severe allergic response often to long-term
Upon inhalation of spores from the fungus Blastomyces dermatitidis environment, humans and animals can develop disease blastomycosis. Based on epidemiology, B. is known to be endemic in United States Canada around Great Lakes Ohio Mississippi River Valleys but starting emerge other areas. extremely difficult culture so little about environmental reservoirs for this pathogen.
ABSTRACT Aspergillus fumigatus is a filamentous fungus which can cause multiple diseases in humans. Allergic Broncho-pulmonary Aspergillosis (ABPA) disease diagnosed primarily Cystic Fibrosis patients caused by severe allergic response often to long-term A. colonization the lungs. Mice develop an repeated inhalation of spores; however, no strains have been identified that survive mouse lung and ABPA-like disease. We characterized strain W72310 whole genome sequencing vitro vivo viability...
Abstract Regulation of fungal cell wall biosynthesis is critical to maintain integrity in the face dynamic infection microenvironments. In this study, we observe that a yeast ssd1 homolog, ssdA, filamentous fungus Aspergillus fumigatus involved trehalose and homeostasis. An ssdA null mutant strain exhibited an increase levels reduction colony growth rate. Over-expression contrast perturbed reduced conidia germination rates. The was more resistant perturbing agents while over-expression...
Abstract Alanine metabolism has been suggested as an adaptation strategy to oxygen limitation in organisms ranging from plants mammals. Within the pulmonary infection microenvironment A. fumigatus forms biofilms with steep gradients defined by regions of limitation. A significant increase alanine levels was observed cultured under limiting conditions. An aminotransferase, AlaA, function catabolism and is required for several aspects biofilm physiology. Loss alaA , or its catalytic activity,...