A5100429076- Cellular Mechanics and Interactions
- Force Microscopy Techniques and Applications
- Caveolin-1 and cellular processes
- Microtubule and mitosis dynamics
- Advanced Fluorescence Microscopy Techniques
- Semiconductor Quantum Structures and Devices
- Proteoglycans and glycosaminoglycans research
- 3D Printing in Biomedical Research
- Photonic and Optical Devices
- Glycosylation and Glycoproteins Research
- Nanomaterials for catalytic reactions
- Erythrocyte Function and Pathophysiology
- TGF-β signaling in diseases
- Quantum-Dot Cellular Automata
- Carbohydrate Chemistry and Synthesis
- Superconducting Materials and Applications
- Lipid Membrane Structure and Behavior
- Hydrogels: synthesis, properties, applications
- Genetic Neurodegenerative Diseases
- MXene and MAX Phase Materials
- Advanced Semiconductor Detectors and Materials
- Retinal Diseases and Treatments
- Endoplasmic Reticulum Stress and Disease
- Genetics and Neurodevelopmental Disorders
- Advanced Antenna and Metasurface Technologies
National University of Singapore
2019-2023
Shenzhen University Health Science Center
2022
Leibniz University Hannover
2022
Northwestern Polytechnical University
2021
Sichuan University
2020
The University of Texas at Austin
2019
Harbin Institute of Technology
2018
University of Alberta
2017
University of Electronic Science and Technology of China
2014
First Bethune Hospital of Jilin University
2012
Micro-Opto-Electro-Mechanical Systems (MOEMS) accelerometer is a new type of which combines the merits optical measurement and Micro-Electro-Mechanical (MEMS) to enable high precision, small volume anti-electromagnetic disturbance acceleration. In recent years, with in-depth research development MOEMS accelerometers, community flourishing possible applications in seismic monitoring, inertial navigation, aerospace other industrial military fields. There have been variety schemes whereas...
Talin and vinculin are part of a multicomponent system involved in mechanosensing cell-matrix adhesions. Both exist autoinhibited forms, activation requires binding to mechanically activated talin, yet how forces affect talin's interaction with has not been investigated. Here by quantifying the kinetics force-dependent talin-vinculin interactions using single-molecule analysis, we show that mechanical exposure single site (VBS) talin is sufficient relieve autoinhibition vinculin, resulting...
Chemically induced dimerization (CID) has been applied to study numerous biological processes and important pharmacological applications. However, the complex multistep interactions under various physical constraints involved in CID impose a great challenge for quantification of interactions. Furthermore, mechanical stability ternary complexes not characterized; hence, their potential application mechanotransduction studies remains unclear. Here, we report single-molecule detector that can...
With the PTFE membrane as substrate, a novel Ag-based catalytic reactor (CMR) was fabricated by deep-permeation synthesis fabrication (DPSF). In DPSF, ZIF-8 first assembled inside pores permeation flow and depositing reaction of Zn2+, 2-methylimidazole solutions through synergistically. Then, Ag reduced impregnating nanoclusters Ag+ reductant flowing similarly. The TEM images cross-sectional exhibited composite nanoparticles Ag+ZIF-8 with good dispersion size distribution (10–50 nm)....
Abstract The measurement of minority carrier lifetimes is vital to determining the material quality and operational bandwidth a broad range optoelectronic devices. Typically, these measurements are made by recording temporal decay carrier-concentration-dependent property following pulsed optical excitation. Such approaches require some combination efficient emission from under test, specialized collection optics, large sample areas, spatially uniform excitation, and/or fabrication ohmic...
GaAs quantum dots (QDs) grown by local droplet etching (LDE) have been studied extensively in recent years. The LDE method allows for high crystallinity, as well precise control of the density, morphology, and size QDs. These properties make QDs an ideal candidate single photon entangled sources at short wavelengths (<800 nm). For technologically important telecom wavelengths, however, it is still unclear whether can be realized. Controlling growth conditions does not enable shifting...
Vinculin is a mechanosensitive adapter protein that links the actin network to cell-extracellular matrix adhesions and cell-cell adhesions. It perhaps best characterized mechanoeffector, as it recruited sites of adhesion in response force on mechanotransducers talin alpha-catenin. Here we examined mechanical properties vinculin assess its potential role mechanotransducer. We find at physiological loading rates, structural domains unfold forces 5-15 pN range rapidly refold when are reduced...
A large portion of the global population has been vaccinated with various vaccines or infected SARS-CoV-2, virus that causes COVID-19. The resulting IgG antibodies target receptor binding domain (RBD) SARS-CoV-2 play a vital role in reducing infection rates and severe disease outcomes. Different immune histories result production anti-RBD different affinities to RBDs variants, levels these decrease over time. Therefore, it is important have low-cost, rapid method for quantifying...
Abstract Talin and vinculin are part of a multi-component system involved in mechanosensing cell-matrix adhesions. Both exist auto-inhibited forms, activation requires binding to mechanically activated talin, yet how forces affect talin’s interaction with has not been investigated. Here by quantifying the force-dependent talin-vinculin interactions kinetics using single-molecule analysis, we show that mechanical exposure single site (VBS) talin is sufficient relieve autoinhibition resulting...
With the increase of performance requirements for lithium-ion batteries (LIBs), it is particularly important to study and develop new electrodes batteries. In this work, a 3×3×1 supercell VS<sub>2</sub> constructed, possibility using as an anode material by first-principles method based on density functional theory. Through analysis energy band diagram, found that has metallic properties. Combining states shows near Fermi level contributed 3d state V 3p electrons S, which means...
The osmotic lysis of photodamaged lysosomes is a critical event for killing tumor cells. How the photodamage increases lysosomal sensitivity still unclear. In this work, effect photooxidation membrane thiol groups on was studied by measuring with 5,5′-dithio-bis(2-nitrobenzoic acid) and examining β-hexosaminidase latency loss in hypotonic sucrose medium. results show that methylene blue–mediated decreased their produced cross-linkage proteins (molecular weight ranging from 75 000 to 125...
A novel reflector antenna system generating electromagnetic field with orbital angular momentum (OAM) is proposed. Composed of a monofilar conical-helix and 20-cm-diameter parabolic-reflector, the proposed can radiate OAM order 2. The simulated results along some key parameters are presented discussed in this study.
Pd and Pt nanotubes were fabricated using self-assembled DC8,9PC lipid tubules under mild conditions at room temperature. Scan electron microscope (SEM) show the hollow open-ended structures of prepared nanotubes. The demonstrate both high catalytic activity toward p-nitrophenol reduction excellent stability. This work has indicated application potentials in fabricating metal nanomaterials.
Glutaminyl cyclase (QC) is responsible for converting the N-terminal glutaminyl and glutamyl of proteins into pyroglutamate (pE) through cyclization. It has been confirmed that QC catalyzes formation neurotoxic pE-modified Aβ in brain AD patients. But effects upregulated diverse diseases have not much clear until recently. Here, RNA sequencing was applied to identify differentially expressed genes (DEGs) PC12 cells with overexpressing or knockdown. A total 697 DEGs were identified while only...