A5004452792- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Nitric Oxide and Endothelin Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Virus-based gene therapy research
- Genetic and phenotypic traits in livestock
- HIV Research and Treatment
- Immune cells in cancer
- Xenotransplantation and immune response
- Healthcare Technology and Patient Monitoring
- Herpesvirus Infections and Treatments
- HIV/AIDS Research and Interventions
- Astronomy and Astrophysical Research
- HIV, Drug Use, Sexual Risk
- CRISPR and Genetic Engineering
- Pregnancy-related medical research
- Plant Virus Research Studies
- Agricultural Economics and Policy
- Quality and Safety in Healthcare
- Livestock Management and Performance Improvement
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
European Space Operations Centre
2018-2025
Australian Regenerative Medicine Institute
2016-2023
Monash University
2012-2023
Public Health England
2016-2022
Imperial College London
2022
Quadram Institute
2022
University of Oxford
2021
Centre for Human Genetics
2021
VIR Biotechnology (United States)
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
The SARS-CoV-2 lineage B.1.1.7, designated variant of concern (VOC) 202012/01 by Public Health England1, was first identified in the UK late summer to early autumn 20202. Whole-genome sequence data collected from community-based diagnostic testing for COVID-19 show an extremely rapid expansion B.1.1.7 during 2020, suggesting that it has a selective advantage. Here we changes VOC frequency inferred genetic correspond closely S gene target failures (SGTF) PCR testing. Analysis trends SGTF and...
Abstract The SARS-CoV-2 lineage B.1.1.7, now designated Variant of Concern 202012/01 (VOC) by Public Health England, originated in the UK late Summer to early Autumn 2020. We examine epidemiological evidence for this VOC having a transmission advantage from several perspectives. First, whole genome sequence data collected community-based diagnostic testing provides an indication changing prevalence different genetic variants through time. Phylodynamic modelling additionally indicates that...
Abstract The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use dense genomic surveillance data generated by COVID-19 Genomics UK Consortium reconstruct dynamics 71 different lineages in each 315 English local authorities between September 2020 and June 2021. This analysis reveals a series subepidemics peaked early autumn 2020, followed jump transmissibility B.1.1.7/Alpha...
Human gene-2 relaxin (H2 relaxin) is a pleiotropic hormone with powerful vasodilatory and anti-fibrotic properties which has led to its clinical evaluation provisional FDA approval as treatment for acute heart failure. The diverse effects of H2 are mediated via cognate G protein coupled-receptor (GPCR), Relaxin Family Peptide Receptor (RXFP1), leading stimulation combination cell signalling pathways that includes cyclic adenosine monophosphate (cAMP) extracellular-signal-regulated kinases...
The Space Technology 7 Disturbance Reduction System (ST7-DRS) is a NASA technology demonstration payload that operated from January 2016 through July 2017 on the European Agency's (ESA) LISA Pathfinder spacecraft. joint goal of and ESA missions was to validate key technologies for future space-based gravitational wave observatory targeting source-rich millihertz band. two primary components ST7-DRS are micropropulsion system based colloidal micro-Newton thrusters (CMNTs) control...
ABSTRACT Porcine endogenous retroviruses (PERVs) pose a potential stumbling block for therapeutic xenotransplantation, with the greatest threat coming from viruses generated by recombination between members of PERV subgroup A (PERV-A) and PERV-C families (PERV-A/C recombinants). PERV-A PERV-B have been shown to infect human cells in culture, albeit low titers. has more restricted host range cannot cells. recombinant PERV-A/C virus (PERV-A14/220) contains sequence end pol middle SU region env...
Human herpesvirus type 1 (HHV-1) has a large double-stranded DNA genome of approximately 152 kbp that is structurally complex and GC-rich. This makes the assembly HHV-1 whole genomes from short-read sequencing data technically challenging. To improve we have employed hybrid protocol using two technologies: Roche 454 long-read Oxford Nanopore MinION sequencers. We sequenced 18 cell culture-isolated clinical specimens collected immunocompromised patients undergoing antiviral therapy. The...
Abstract The evolution of the SARS-CoV-2 pandemic continuously produces new variants, which warrant timely epidemiological characterisation. Here we use dense genomic surveillance generated by COVID-19 Genomics UK Consortium to reconstruct dynamics 71 different lineages in each 315 English local authorities between September 2020 and June 2021. This analysis reveals a series sub-epidemics that peaked early autumn 2020, followed jump transmissibility B.1.1.7/Alpha lineage. Alpha grew when...
Reactive oxygen species (ROS) promote growth factor signalling including for VEGF-A and have potent angiogenic tumourigenic properties. However, the precise enzymatic source of ROS generation, subcellular localization production cellular targets in vivo that influence tumour-promoting processes, are largely undefined. Here, using mRNA microarrays, we show increased gene expression NOX2, catalytic subunit ROS-generating NADPH oxidase enzyme, human primary prostate cancer compared to...
In Liverpool, injecting drug users (IDUs), men-who-have-sex-with-men (MSM) and UK Africans experience a disproportionate burden of HIV, yet services do not reach out to these groups late presentations continue. We set to: increase testing uptake in targeted marginalized through community genitourinary medicine (GUM)-based point care (POCT) programme; conduct process evaluation examine service provider inputs document user perceptions the programme. Mixed quantitative, qualitative methods...
Since 2013, the London HIV Mortality Review Group has conducted annual reviews of deaths among people with to reduce avoidable mortality.All care Trusts reported data on 2016 patient in 2017. Deaths were submitted using a modified Causes Death reporting form and categorized by specialist pathologist two clinicians.There 206 reported; 77% men. Median age at death was 56 years. Cause established for 82% deaths, non-AIDS-related malignancies AIDS-defining illnesses being most common causes...
H2 relaxin is a peptide hormone that exerts its biological actions through the G protein-coupled receptor, RXFP1. The numerous important functions of relaxin, including potent renal, vasodilatory, cardioprotective, and anti-fibrotic actions, have resulted in considerable interest use as therapeutic for various cardiovascular diseases other fibrotic indications. Interestingly though, RXFP1 been shown to be overexpressed prostate cancer, allowing downregulation or blocking relaxin/RXFP1...
Abstract Background Previous reports have shown that peptides derived from the apolipoprotein E receptor binding region and amphipathic α-helical domains of AI broad anti-infective activity antiviral respectively. Lipoproteins viruses share a similar cell biological niche, being overlapping size displaying interactions with mammalian cells receptors, which may led to other sequences arising within apolipoproteins, in addition those previously reported. We therefore designed series based...
Cytomegalovirus (CMV) is the most common congenital infection in humans and a leading cause of sensorineural hearing loss. Ganciclovir (6 mg/kg twice daily for 42 days) has been shown to reduce deterioration used clinical practice. Vaccines passive administration antibody are being evaluated randomized controlled trials allograft candidates, women childbearing age, pregnant with primary CMV infection. To help define genetic variation each targets these therapeutic interventions, we amplified...
Abstract Whole-genome sequencing (WGS) information has played a crucial role in the SARS-CoV-2 (COVID-19) pandemic by providing evidence about variants to inform public health policy. The purpose of this study was assess representativeness sequenced cases compared with all COVID-19 England, between March 2020 and August 2021, demographic socio-economic characteristics, evaluate utility these data epidemiological analyses. To achieve this, polymerase chain reaction (PCR)-confirmed were...
PLATO (PLAnetary Transits and Oscillations) mission is a space-based optical multi-camera photometer of the European Space Agency (ESA) to identify characterize exoplanets their hosting stars using two main techniques: planetary transit asteroseismology. Selected as M3 (third Medium class mission) ESA 2015-2025 Cosmic Vision program, scheduled launch end 2026 designed for 4 years nominal observation. The spacecraft composed Service Module Payload Module. comprises all conventional subsystems...
Measurements of weak gravitational lensing using the cosmic microwave background and shapes galaxies have refined our understanding late-time history Universe. While optical surveys been primary source for shear measurements, radio continuum offer a promising avenue. Relevant sources, principally star-forming galaxies, populations with higher mean redshifts are less affected by dust extinction compared to sources. We focus on future mid frequency SKA telescope explore cross-correlation...