A5053182124- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Insect and Pesticide Research
- Leprosy Research and Treatment
- Synthesis and Biological Evaluation
- Urologic and reproductive health conditions
- Dermatological diseases and infestations
- Cutaneous Melanoma Detection and Management
- Toxin Mechanisms and Immunotoxins
- Psoriasis: Treatment and Pathogenesis
- Insect Pest Control Strategies
- Male Reproductive Health Studies
- Retinoids in leukemia and cellular processes
- Sperm and Testicular Function
- Digital Imaging for Blood Diseases
- Long-Term Effects of COVID-19
- Fungal Infections and Studies
- Bartonella species infections research
- Genetic and rare skin diseases.
- Autoimmune and Inflammatory Disorders
- Urticaria and Related Conditions
- Rabies epidemiology and control
- Nonmelanoma Skin Cancer Studies
- Genetics, Bioinformatics, and Biomedical Research
- Bioactive Compounds and Antitumor Agents
Universidade de Brasília
2018-2024
Hospital Universitário de Brasília
2020-2024
Universidade de Pernambuco
2014-2016
Protective effects of Bacillus Calmette-Guérin (BCG) vaccination and clofazimine dapsone treatment against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported. Patients at risk for leprosy represent an interesting model assessing the these therapies on occurrence severity disease 2019 (COVID-19). We assessed influence leprosy-related variables in COVID-19.We performed a 14-month prospective real-world cohort study which main factor was previous...
Experts have called attention to the possible negative impact of coronavirus disease 2019 (COVID-19)-related cytokine storm syndrome on progression leprosy-related disabilities. We assessed frequency reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory (SARS) (CoV) 2 (SARS-CoV-2). consecutively included during first peak COVID-19 epidemic Brazil analyzed expressions genes encoding interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12A, IL-12B, tumor...
Introduction: Diffuse Cutaneous Leishmaniasis (DCL) is a rare disease form associated with L. (L.) amazonensis in South America. It represents the "anergic" pole of American Tegumentary and explanation for its resistance to treatment remains elusive. We aimed study some possible immunological mechanisms involved poor DCL response by evaluating cell surface molecules obtained from patient flow cytometry. Case presentation: A 65-year-old who initially failed respond standard showed vacuolated...
Introduction American tegumentary leishmaniasis (ATL), which can present as either cutaneous (CL) or mucosal (ML), is endemic in South America, and first-line antimonial treatments are known for their wide range of adverse effects (AEs). Growing reports drug resistance increase the urgency need better treatment options. The objective this pilot clinical trial was to assess efficacy AEs associated with oral combination miltefosine pentoxifylline based on a post hoc analysis. Methods A pilot,...
The polymorphism of cutaneous leishmaniasis (CL) complicates diagnosis in health care services because lesions may be confused with other dermatoses such as sporotrichosis, paracocidiocomycosis, and venous insufficiency. Automated identification skin diseases based on deep learning (DL) has been applied to assist diagnosis. In this study, we evaluated the performance AlexNet, a DL algorithm, identify pictures CL patients from Midwest Brazil. We used set 2458 (up 10 each lesion) obtained...
INTRODUCTION: The treatment of mucosal leishmaniasis (ML) is difficult due to the toxicity and route administration standard drugs. Miltefosine an oral agent used for treatment; however, no data exist regarding its use ML in Brazil. In this study, we aimed evaluate efficacy miltefosine compared that pentavalent antimonial a pilot study. METHODS: We performed randomized clinical trial with two parallel groups. tested intervention consisted 1.3-2 mg/kg/day (two capsules) 28 days or intravenous...
Pentavalent antimonials (PAs) are the primary therapeutic option for American tegumentary leishmaniasis (ATL). However, use of these drugs is complicated by adverse events (AEs), resistance and contraindications. Alternative therapies relative effectiveness not well established.This study compared liposomal amphotericin B (LAB) with intravenous meglumine antimoniate (NMG) in treatment ATL. We also analysed associated AEs interruption rates.This was a retrospective cohort from Brazil. The...
As highly specific molecular biology-based techniques may not be sensitive enough for the diagnosis of American tegumentary leishmaniasis (ATL), clinicians frequently rely on immunological tests before treatment initiation. Hence, correct combination diagnostic is imperative ATL diagnosis. We aimed to evaluate accuracy Montenegro (Leishmanin) skin test (MST) in polymerase chain reaction (PCR)-negative patients accurately detect ATL.Patients with a clinical picture compatible were divided...
The standard therapy for American cutaneous leishmaniasis (ACL) is intravenous meglumine antimoniate (IV-MA). However, treatment interruptions due to adverse events (AEs) and non-adherence are frequent. Consequently, intralesional MA (IL-MA) was proposed. This study examined the effectiveness of AEs associated with IL-MA. We performed a retrospective cohort 240 patients ACL. excluded mucous lesions disseminated those who received in previous 6 months. considered protocol treatments as main...
Previous studies have discussed the low prevalence of psoriasis among indigenous peoples South America. The state Roraima, Brazil, where present study was performed, is crossed by equator line. It likely that key factors for absence in this population include genetic factors, a lack environmental triggers and high sun exposure.
In Brazil, visceral Leishmaniasis is caused by Leishmania chagasi. The development of cutaneous lesions in leishmaniasis patients has been described two different clinical contexts. Patients with compromised immunity can develop skin as a direct consequence current disease. Equally, history kala-azar and progressive, immune improvement occasionally reconstitution infl ammatory syndrome. These cases manifest similar fashion to the classic form post-kala-azar dermal Leishmaniasis. We describe...
RESUMO Deep Learning é uma técnica de aprendizado máquina na qual o programa computacional aprende padrões diretamente a partir imagens classificadas previamente. O presente ensaio objetivou apresentar essa e algumas suas aplicações para diagnóstico doenças identificação insetos vetores incentivar profissionais da saúde que não tenham conhecimento aprofundado em informática desejem utilizar ferramenta realizar análises automatizadas. tem sido aplicado câncer, fibrose cardíaca, tuberculose,...
Leishmania braziliensis is the most important causal agent of American tegumentary leishmaniasis (ATL), and 3 to 5% patients develop mucosal lesions. The mechanisms related parasite host immune interactions life cycle that lead dissemination mucosa are poorly understood. We aimed detect L. DNA in nasal cutaneous (CL) with early mucous relate those findings specific inflammatory responses. Nasal swabs were collected from form ATL. was investigated using TaqMan-based real-time PCR. levels...
Dermatofibroma is a frequent benign tumor of easy clinical diagnosis in most cases, but that can mimic other dermatoses. Dermoscopy may help to define the and its classical pattern central white area, similar scar, surrounded by discrete pigment network. However, dermoscopic findings are not always typical. We describe here case dermatofibroma exhibiting ridges, furrows pseudocomedos, which typical seborrheic keratosis, dermoscopy.
Mucosal leishmaniasis (ML) is a deforming type of American Tegumentary Leishmaniasis caused by
Background: Tungiasis is a disease associated with extreme poverty. We aimed to evaluate the prevalence of tungiasis in six different settlements Sanumás indigenous community remote area Auaris region, Yanomami territory, Brazil. Methods: conducted an observational study detect clinical and epidemiological factors using cross-sectional strategy multivariate logistic regression. Soil analysis was performed by visual microscopic methods. Results: examined 555 persons, 45 whom had active...
To find out the changes in seminal quality of hemodialysis chronic renal patients, we investigated possible relationship between parameter and α1-acid glycoprotein levels patients.Prospective study prevalence realized Hemodialysis Sector University Hospital Brasília, July 2016 December 2016. Men aged 18-60 years grouped into case groups (n = 81) represented by patients control group 20) healthy men without clinical or laboratory signs infection eugonadic. We performed a spermogram, hormonal...
A síndrome de Melkersson-Rosenthal é composta pela tríade: língua plicata, paralisia facial intermitente e edema orofacial. O achado dominante mais precoce o Desta forma, dermatologista frequentemente primeiro profissional a ter contato com paciente. condição tem sido pouco descrita em revistas dermatológicas. Apresentamos um caso clássico da tríade completa.
Uma variedade de lesões cutâneas pode simular melanoma, tais como nevos melanocíticos, lentigos, ceratose seborreica, nevo azul, carcinoma basocelular pigmentado e dermatofibromas. Relata-se um caso clínico raro uma paciente do sexo feminino que apresentou lesão em coxa esquerda clínica dermatoscopicamente compatível com melanoma. A foi submetida à exérese da o histopatológico diagnosticou doença Bowen pigmentada. O objetivo é alertar a pigmentada, forma rara espinocelular in situ, também...
Background: The success of tungiasis treatment is highly dependent on adequate environmental control. Methods: This a real-world observational cohort study designed to monitor the effectiveness topical dimethicone together with One Health approach for control in Sanumás communities, Amazon rainforest, Brazil. We followed up 562 indigenous people and 81 domestic dogs 1.5 years 3-month interval. A new molecular method large-scale soil evaluation was also tested. independently conducted by...