A5015190922- Marine Sponges and Natural Products
- Ethics in Clinical Research
- Rabies epidemiology and control
- Biomedical Ethics and Regulation
- Virology and Viral Diseases
- Viral Infections and Vectors
- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- BRCA gene mutations in cancer
- Genomics and Rare Diseases
- Reproductive tract infections research
- Aquaculture disease management and microbiota
- Prenatal Screening and Diagnostics
- Microbial Metabolic Engineering and Bioproduction
- Urinary Tract Infections Management
- Gut microbiota and health
- Protist diversity and phylogeny
- Dermatological and COVID-19 studies
- Indigenous Health, Education, and Rights
- Vibrio bacteria research studies
- Health Policy Implementation Science
- Marine Biology and Ecology Research
- Mollusks and Parasites Studies
- Chromatography in Natural Products
- Plant-based Medicinal Research
QIMR Berghofer Medical Research Institute
2020-2023
University of the Sunshine Coast
2015-2018
Department of Primary Industries
2016
Department of Agriculture, Fisheries and Forestry
2015
The University of Queensland
2011-2014
James Cook University
2006
The natural course of Chlamydia trachomatis urogenital tract infections varies between individuals. While protective immunity can occur, some women become reinfected, contributing to the development severe pathology. reasons for these differences are unknown, an individual's response induced interferon-γ (IFN-γ) is suggested be critical. IFN-γ induction enzyme indoleamine 2,3-dioxygenase, which depletes tryptophan, may key. One hypothesis suggests that indole-producing bacteria in vaginal...
Pteropid bats or flying-foxes (Chiroptera: Pteropodidae) are the natural host of Hendra virus (HeV) which sporadically causes fatal disease in horses and humans eastern Australia. While there is strong evidence that urine an important infectious medium likely drives bat to transmission horse transmission, uncertainty about relative importance alternative routes excretion such as nasal oral secretions, faeces. Identifying potential HeV effectively mitigate equine exposure risk at bat-horse...
Abstract The complexities of the informed consent process for participating in research genomic medicine are well-documented. Inspired by potential Dynamic Consent to increase participant choice and autonomy decision-making, as well opportunities ongoing engagement it affords, we wanted trial do so developed our own web-based application (web app) called CTRL (control). This paper documents design development CTRL, use Australian Genomics study: a health services project building evidence...
Hendra virus (HeV) is a lethal zoonotic agent that emerged in 1994 Australia. Pteropid bats (flying-foxes) are the natural reservoir. To date, HeV has spilled over from flying-foxes to horses on 51 known occasions, and infected close-contact humans seven occasions. We undertook screening of archived bat tissues for by reverse transcription quantitative polymerase chain reaction (RT-qPCR). Tissues were tested 310 including 295 Pteropodiformes 15 Vespertilioniformes. was detected 20 individual...
Hendra virus (HeV) continues to cause fatal infection in horses and threaten close-contact humans eastern Australia. Species of Pteropus bats (flying-foxes) are the natural reservoir virus. We caught sampled flying-foxes from a multispecies roost southeast Queensland, Australia on eight occasions between June 2013 2014. The effects sample date, species, sex, age class, body condition score (BCS), pregnancy lactation HeV antibody prevalence, log-transformed median fluorescent intensity...
Acute rheumatic fever and heart disease (ARF/RHD) have long been described as autoimmune sequelae of Streptococcus pyogenes or group A streptococcal (GAS) infection. Both antibody T-cell responses against immunodominant GAS virulence factors, including M protein, cross-react with host tissue proteins, triggering an inflammatory response leading to permanent damage. However, in some ARF/RHD-endemic regions, throat carriage is low. Because dysgalactiae subspecies equisimilis organisms, also...
In health and medical research, guidelines are a set of statements recommendations, whereby experts or stakeholders assess published literature to generate practical advice for specific audience. This emphasis on development with expert consultation is not inclusive when working in disciplines minimal data addressing issues that concern under-represented communities. Here we describe the process used developing conduct genomic research projects partnership Aboriginal Torres Strait Islander...
Patterns of inter-species secondary metabolite production by bacteria can provide valuable information relating to species ecology and evolution. The complex nature this chemical diversity has previously been probed via directed analyses a small number compounds, identified through targeted assays rather than more comprehensive biochemical profiling approaches such as metabolomics. Insights into ecological evolutionary relationships within bacterial genera be derived comparative analysis...
Many families and individuals do not meet criteria for a known hereditary cancer syndrome but display unusual clusters of cancers. These may carry pathogenic variants in predisposition genes be at higher risk developing cancer.This multi-centre prospective study recruited 195 cancer-affected participants suspected to have whom previous clinical targeted genetic testing was either informative or available. To identify disease-causing explaining participant presentation, germline whole-genome...
Chlamydia is a major bacterial pathogen in humans and animals globally. Yet 80% of infections never progress to clinical disease. Decades research have generated an interconnected network linking pathogen, host, environmental factors disease expression, but the relative importance these whether they account for progression remains unknown. To address this, we used structural equation modeling evaluate putative likely contribute urogenital ocular chlamydial koala (Phascolarctos cinereus)....
To determine if infection of Vibrio harveyi with the V. myovirus-like (VHML) bacteriophage causes a change to phenotypic profile this species.Using 46 biochemical and metabolic tests, profiles for noninfected VHML infected were developed. Comparison bacteriophage-infected strains 645, 20 45 found have different test results d-gluconate utilization, gamma-glutamyl transpeptidase sulfatase activity, respectively. Using probabilistic identification, identified as had similar Willcox probability...
Abstract Background There has been considerable investment and strategic planning to introduce genomic testing into Australia’s public health system. As more patients’ data is being held by the system, there will be increased requests from researchers access this data. It important that policy reflects expectations for how generated clinical tests used. To inform discussions around sharing, we sought opinions on using contained in medical records research purposes Australian state of...
Understanding the diversity of henipaviruses and related viruses is important in determining viral ecology within flying-fox populations assessing potential threat posed by these agents. This study sought to identify abundance previously unknown paramyxoviruses (UPVs) Australian species (Pteropus alecto, Pteropus scapulatus, poliocephalus conspicillatus) Christmas Island melanotus natalis. Using a degenerative reverse transcription-PCR specific for L gene known genus Henipavirus two closely...
Abstract Disease caused by Chlamydia pecorum is characterised ocular and urogenital infections that can lead to blindness infertility in koalas. However, koalas are infected with C . do not always progress disease. In other host systems, the influence of microbiota has been implicated either accelerating or preventing progressing This study investigates contribution koala infection disease a free ranging population. Using univariate multivariate analysis, it was found reproductive status...
Health Interpreters enable effective communication between health practitioners and patients with limited knowledge of the predominant language. This study developed evaluated a training session introducing to genetics. The online was delivered multiple times as single 2-h comprising lectures activities. Participants completed questionnaires (pre-, post-, 6-months follow-up) assess impact on knowledge, attitude, self-efficacy, self-reported practice behaviour. Questionnaires were analysed...
As genetic testing becomes increasingly utilized in health care, consumer awareness and understanding is critical. Both are reported to be low Australia, though there limited studies date. A survey assessed perceived knowledge, attitudes toward medicine, prior consumers' genomics forums Queensland 2018 2019. Data was analyzed using t-test Mann-Whitney U tests analysis detect any associations between sociodemographic factors familiarity or attitudes. This highly educated experienced cohort...
Summary Hendra virus (HeV) causes potentially fatal respiratory and/or neurological disease in both horses and humans. Although Australian flying‐foxes of the genus Pteropus have been identified as reservoir hosts, precise mechanism HeV transmission has yet to be elucidated. To date, there limited investigation into role haematophagous insects vectors HeV. This mode is particularly relevant because host bat‐specific blood‐feeding ectoparasites Cyclopodia (Diptera: Nycteribiidae), also known...
Abstract Background: There has been considerable investment and strategic planning to introduce genomic testing into Australia’s public health system. As more patients’ data is being held by the system, there will be increased requests from researchers access this data. It important that policy reflects expectations for how generated clinical tests used. To inform discussions around sharing, we sought opinions on using contained in medical records research purposes Australian state of...