A5100369726- Systemic Lupus Erythematosus Research
- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pregnancy and Medication Impact
- Cytomegalovirus and herpesvirus research
- Heat shock proteins research
- 3D Printing in Biomedical Research
- Cancer Mechanisms and Therapy
- Dental Health and Care Utilization
- Spondyloarthritis Studies and Treatments
- Anesthesia and Neurotoxicity Research
- Chronic Kidney Disease and Diabetes
- Oral Health Pathology and Treatment
- Inflammasome and immune disorders
- Herpesvirus Infections and Treatments
- Systemic Sclerosis and Related Diseases
- Immune Cell Function and Interaction
- Pluripotent Stem Cells Research
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Atherosclerosis and Cardiovascular Diseases
- Ginkgo biloba and Cashew Applications
- Pregnancy and preeclampsia studies
Shimadzu (Japan)
2024-2025
Dalian Medical University
2021-2024
First Affiliated Hospital of Dalian Medical University
2021-2024
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2024
Shimadzu (China)
2024
Second Hospital of Shanxi Medical University
2020-2023
Shanxi Medical University
2020-2023
Shanghai Institute of Hypertension
2023
Affiliated Hospital of Hebei University
2022
Hebei Medical University
2022
Diabetes and periodontitis, as widespread chronic diseases, often exacerbate each other's conditions. Nonsurgical periodontal treatments can improve the oral systemic health in these patients, with salivary proteins offering potential insights into disease mechanisms treatment effectiveness. However, there is a lack of comprehensive data on proteomics this context. By assigning patients diabetes-associated periodontitis to test group (supragingival scaling, subgingival scraping root planing)...
Heat shock proteins (HSP) have been associated with a range of persistent inflammatory disorders; however, little research has conducted on the involvement HSP in development ankylosing spondylitis (AS). The aims to identify diagnostic signature based HSP-related genes and determine molecular subtypes AS. We gathered transcriptional data patients AS from GSE73754 dataset literature search for (HRGs). logistic regression model was utilized identification hub HRGs Subsequently, these were...
<h3>Background:</h3> In the current scenario, population issue is becoming increasingly severe, prompting greater attention to pregnancy. It well-known that during pregnancy, maternal immune system must tolerate semi-allogeneic fetus. This situation, when occurring in autoimmune diseases, may trigger disease relapse. Another previous meta-analysis demonstrated dynamic changes pregnancy risks for women with diseases depend on factors such as activity, organ damage, autoantibody titers, and...
ABSTRACT Objective This study aimed to analyze the subgingival and salivary microbiome metabolome in diabetic periodontitis patients with varying glycemic levels. Methods Forty‐two were sampled of saliva, gingival crevicular fluid (GCF), blood, categorized into three groups based on systemic status. The was assessed using full‐length 16S rRNA gene sequencing. Gas chromatography–mass spectrometry performed for analysis. Results similarity structure function flora saliva GCF evident under good...
1. Kiriakidou M, Ching CL. Systemic lupus erythematosus. Ann Intern Med 2020; 172: ITC81-96. Google Scholar
Chronic kidney disease (CKD) is a progressive and irreversible pathological feature with no effective therapies in clinic. Persistent inflammation key characteristic of CKD that leads to renal fibrosis. Cathepsin S (Cat S) cysteine protease contributing the progression multiple diseases through modulating inflammation, but its role pathogenesis remains unknown. Here, we found Cat was significantly upregulated macrophage during unilateral ureteral obstruction (UUO). Knockout attenuated,...
<title>Abstract</title> <bold>Background</bold> The interferon-gamma (IFN-γ) signaling pathway is activated in Systemic lupus erythematosus (SLE). This study aims to assess the causal association between IFN-γ, IFN-γR1, and IFN-γR2 SLE within a bidirectional Mendelian-randomization design.<bold>Methods</bold> Genetic instruments of exposure were derived from large genome-wide (GWAS), including 3,301 sample size. Instrumental variables for selected another independent GWAS analysis comprising...
Background: Recent studies have reported that some drugs such as low-dose interleukin-2, rapamycin, metformin, retinoic acid and coenzyme Q10 could promote the proliferation functional recovery of regulatory T cells (Treg) in patients with autoimmune diseases. However, effects on balance Treg pro-inflammatory lymphocytes long-term efficacy rarely been reported. Objectives: To evaluate changes peripheral lymphocyte subsets, conventional remission rate systemic lupus erythematosus (SLE) after...