A5033801561- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Catalytic Processes in Materials Science
- Mesoporous Materials and Catalysis
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Hydraulic and Pneumatic Systems
- Occupational and environmental lung diseases
- Lung Cancer Research Studies
- biodegradable polymer synthesis and properties
- Engineering Applied Research
- Pneumothorax, Barotrauma, Emphysema
- Advanced Polymer Synthesis and Characterization
- Pancreatic function and diabetes
- Polyoxometalates: Synthesis and Applications
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Software Testing and Debugging Techniques
- MicroRNA in disease regulation
- Metastasis and carcinoma case studies
- Advanced Measurement and Detection Methods
Dalian Medical University
2020-2024
Helmholtz Zentrum München
2023-2024
Ludwig-Maximilians-Universität München
2023-2024
German Center for Lung Research
2023-2024
Hebei University of Technology
2012-2014
Zhanjiang Experimental Station
2008
Background We aimed to characterize serine protease inhibitor Kazal type 1 ( SPINK1 ) as a gene signature for the early diagnosis, molecular targeting, and prediction of immune checkpoint blockade (ICB) treatment response hepatocellular carcinoma (HCC). Methods The transcriptomics, proteomics, phenotypic analyses were performed separately or in combination. Results obtained following findings on . Firstly, transcriptomic training dataset, which included 279 stage I II tumor samples (out...
Small cell lung cancer (SCLC) is mostly diagnosed in stage III-IV patients and associated with poor prognosis. To date, surgery no gold-standard treatment for any SCLC evidence lacking whether it beneficial. Here we investigate the impact of surgery, special attention to III patients, sub-stages combinations.
Pleural effusions frequently signal disseminated cancer. Diagnostic markers of pleural malignancy at presentation that would assess cancer risk and streamline diagnostic decisions remain unidentified. A consecutive cohort 323 patients with effusion (PE) from different etiologies were recruited between 2013 2017 was retrospectively analyzed. Data included history, chest X-ray, blood/pleural fluid cell counts biochemistry. Group comparison, receiver-operator characteristics, unsupervised...
ABSTRACT Importance Pleural effusions frequently signal disseminated cancer. Diagnostic markers of pleural malignancy at presentation that would assess cancer risk and streamline diagnostic decisions remain unidentified. Objective The present study aimed identifying validating predictors malignant effusion patient presentation. DESIGN, SETTING, AND PARTICIPANTS A consecutive cohort 323 patients with (PE) from different etiologies were recruited between 2013-2017 was retrospectively analyzed....
Abstract SPINK1 has been regarded as a reversible trypsinogen inhibitor for the inappropriate activation of trypsin, key step in initiation acute pancreatitis (AP). However, mechanisms its action remains largely unclear and controversial. Here, we reported an unexpected effects on inhibiting through regulation impaired autophagy cerulein-stimulated AR42J cells, well-established vitro model pancreatitis. Firstly, found that autophagic flux was induced activity enhanced above setting. Then,...