A5054097041- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Antimicrobial Peptides and Activities
- Mesoporous Materials and Catalysis
- Ginger and Zingiberaceae research
- Bone Tissue Engineering Materials
- Synthesis and Characterization of Heterocyclic Compounds
- Quinazolinone synthesis and applications
- Cholesterol and Lipid Metabolism
- Iron oxide chemistry and applications
- Biosensors and Analytical Detection
- Radiation Effects and Dosimetry
- Radiation Therapy and Dosimetry
- Synthesis and biological activity
- TiO2 Photocatalysis and Solar Cells
- MicroRNA in disease regulation
- biodegradable polymer synthesis and properties
- Synthesis of Tetrazole Derivatives
- Dental Implant Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Antimicrobial agents and applications
- Advanced biosensing and bioanalysis techniques
- Water Quality Monitoring and Analysis
- Biochemical and Structural Characterization
Extreme Light Infrastructure - Nuclear Physics
2020-2024
Horia Hulubei National Institute for R and D in Physics and Nuclear Engineering
2020-2024
Universitatea Națională de Știință și Tehnologie Politehnica București
2024
National Institute of Materials Physics
2022-2023
Romanian Academy
2002-2023
University of Bucharest
2020-2022
Academy of Romanian Scientists
2007
Cancer is a multifaceted health issue that affects people globally and it considered one of the leading causes death with high percentage victims worldwide. In recent years, research studies have uncovered great advances in cancer diagnosis treatment. But, there are still major drawbacks conventional therapies used including severe side effects, toxicity, drug resistance. That why critical to develop new drugs advantages like low cytotoxicity no treatment resistance cells. Antimicrobial...
Introduction Gut microbes pose challenges like colon inflammation, deadly diarrhea, antimicrobial resistance dissemination, and chronic disease onset. Development of early, rapid specific diagnosis tools is essential for improving infection control. Point-of-care testing (POCT) systems offer rapid, sensitive, low-cost sample-to-answer methods microbe detection from various clinical environmental samples, bringing the advantages portability, automation, simple operation.
Complexes with mixed ligands [Cu(N-N)2(pmtp)](ClO4)2 ((1) N-N: 2,2′-bipyridine; (2) L: 1,10-phenanthroline and pmpt: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesized structurally biologically characterized. Compound (1) crystallizes into space group Pa in P-1. Both complexes display an intermediate stereochemistry between the two five-coordinated ones. The biological tests indicated that compounds exhibited superoxide scavenging capacity, intercalative DNA properties,...
Due to the fact of their ability bond with human’s hard tissue, bioglasses have gained interest in biomedical field certain purposes regarding usage replacement, healing or repair bones. In form thin films, they trigger an increase biocompatibility for inert supports after implantation, based on surface engineering ensure osteoinduction. For that, this research is focused obtaining coatings cerium-enriched bioglass generate bioactive and potential additional antimicrobial antioxidant...
A series of five novel copper(II) complexes with imidazole derivatives having general core Cu(R-Im)
The purpose of this work was to propose and evaluate a new composition for bioactive glass-ceramic starting from the well-known 45S5 commercial product. Thus, we developed modified version, including MgO, an oxide that turned out induce superior mechanical properties improved biological response. This had following molar percentages: 46.1% SiO2, 2.6% P2O5, 16.9% CaO, 10.0% 24.4% Na2O. precursor alkoxides nitrates were processed by standard sol-gel technique, resulting in target, suitable...
Antimicrobial peptides are molecules synthetized by a large variety of organisms as an innate defense against pathogens. These natural compounds have been identified promising alternatives to widely used treat infections and cancer cells. could be viewed future chemotherapeutic alternatives, having the advantage low propensity drug resistance. In this study, we evaluated efficiency antimicrobial peptide gramicidin A (GA) anticancer drug, doxorubicin (Doxo) spheroids from colorectal cells...
Novel complexes of type [Cu(N-N)(dmtp)
Clinical data implicate fluctuations of high levels plasma glucose in cardiovascular diseases. Endothelial cells (EC) are the first vessel wall exposed to them. Our aim was evaluate effects oscillating (OG) on EC function and decipher new molecular mechanisms involved. Cultured human ECs (EA.hy926 line primary cells) were OG (5/25 mM alternatively at 3 h), constant HG (25 mM) or physiological concentration (5 mM, NG) for 72 h. Markers inflammation (Ninj-1, MCP-1, RAGE, TNFR1, NF-kB, p38...
The current study reports on the fabrication of composite scaffolds based polycaprolactone (PCL) and cerium (Ce)-containing powders, followed by their characterization from compositional, structural, morphological, optical biological points view. First, CeO2, Ce-doped calcium phosphates Ce-substituted bioglass were synthesized wet-chemistry methods (precipitation/coprecipitation sol-gel) subsequently loaded PCL fibres processed electrospinning. powders proven to be nanometric or micrometric,...
Scope To assess the impact of ginger extract (GIN) in stimulating production quality HDL and cholesterol efflux small intestine (SI), key processes management hyperlipidemia (HL)‐induced hepatic steatosis, atherosclerosis. Methods results Three groups hamsters are used: (i) N, fed standard diet, (ii) HL, high‐fat diet for 21 weeks, (iii) HL‐GIN, HL treated with GIN last 5 weeks diet. Apolipoprotein A‐I (apoA‐I), malondialdehyde‐apoA‐I (MDA‐apoA‐I), paraoxonase1 (PON1), myeloperoxidase (MPO)...
Silver/silver chloride nanoparticles (Ag/AgClNPs), with a mean size of 48.2 ± 9.5 nm and zeta potential value −31.1 1.9 mV, obtained by the Green Chemistry approach from mixture nettle grape extracts, were used as “building blocks” for “green” development plasmonic biohybrids containing biomimetic membranes chitosan. The mechanism biohybrid formation was elucidated optical analyses (UV–vis absorption emission fluorescence, FTIR, XRD, SAXS) microscopic techniques (AFM SEM). aforementioned...
The phase composition, local structure and magnetic interactions were investigated in FexOx –SiO2 nanocomposites obtained by modern sol-gel methods. very sensitive method of Mössbauer spectroscopy has evidenced the strong influence silica matrix precursor on iron composition initial composites as well size distribution hematite nanoparticles suitable thermal annealing treatments. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)