A5016290722- Antimicrobial Peptides and Activities
- Bone Tissue Engineering Materials
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Lipid Membrane Structure and Behavior
- Nanoparticles: synthesis and applications
- Metal complexes synthesis and properties
- Advanced NMR Techniques and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Biochemical and Structural Characterization
- Electrospun Nanofibers in Biomedical Applications
- Quantum Dots Synthesis And Properties
- Nanocomposite Films for Food Packaging
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- Quinazolinone synthesis and applications
- Synthesis of Tetrazole Derivatives
- Chemical Synthesis and Analysis
- Advanced biosensing and bioanalysis techniques
- biodegradable polymer synthesis and properties
- Advanced Nanomaterials in Catalysis
- Synthesis and biological activity
- Moringa oleifera research and applications
- Healthcare and Venom Research
- Advancements in Transdermal Drug Delivery
Horia Hulubei National Institute for R and D in Physics and Nuclear Engineering
2014-2024
Extreme Light Infrastructure - Nuclear Physics
2016-2024
National Institute of Materials Physics
2022-2023
Czech Academy of Sciences, Institute of Physics
2023
Hasselt University
2013-2016
University of Bucharest
2013
Bacterial cellulose (BC) is a biopolymer whose properties have been intensively studied, especially for biomedical applications. Since BC has no antimicrobial activity, it necessary to use bioactive substances developing wound healing Another drawback of the loss if its water retention capacity after dehydration. In order overcome these problems, carboxymethyl (CMC) and turmeric extract (TE) were selected preparation composites. Citric acid (CA) was used as crosslinking agent. These...
Cancer is a multifaceted health issue that affects people globally and it considered one of the leading causes death with high percentage victims worldwide. In recent years, research studies have uncovered great advances in cancer diagnosis treatment. But, there are still major drawbacks conventional therapies used including severe side effects, toxicity, drug resistance. That why critical to develop new drugs advantages like low cytotoxicity no treatment resistance cells. Antimicrobial...
A short antimicrobial peptide (AMP), rich in tryptophan and arginine (P6-HRWWRWWRR-NH2), was used molecular dynamics (MD) simulations to investigate the interaction between AMPs lipopolysaccharides (LPS) from two E. coli outer membrane (OM) models. The OM of Gram-negative bacteria is an asymmetric bilayer, with layer consisting exclusively lipopolysaccharide molecules lower leaflet made up phospholipids. mechanisms by which permeate are not well understood at moment. For this study, types...
The augmented increase in bacterial antimicrobial resistance necessitates the discovery of alternative molecules such as short peptides (AMPs) with activity and low cytotoxicity. While many have been studied, their selective affinity for versus mammalian membranes remains unclear. Here, we propose a complementary approach using state-of-the-art fluorescence experiments, molecular dynamics simulations, theoretical techniques. main goal this is to unravel energetics interactions AMPs different...
Here we describe a new BODIPY-based membrane probe (1) that provides an alternative to dialkylcarbocyanine dyes, such as DiI-C18, can be excited in the blue spectral region. Compound 1 has unbranched octadecyl chains at 3,5-positions and meso-amino function. In organic solvents, absorption emission maxima of are determined mainly by solvent acidity dipolarity. The fluorescence quantum yield is high reaches 0.93 2-propanol. decays well fitted with single-exponential pure solvents small giant...
Protein and peptide interactions are characterized in the liquid state by multidimensional NMR spectroscopy experiments, which can take hours to record. We show that starting from hyperpolarized HDO, two-dimensional (2D) proton correlation maps of a peptide, either free solution or interacting with liposomes, be acquired less than 60 s. In standard 2D without hyperpolarization, acquisition time required for similar spectral correlations is on order hours. This experiment enables...
In this work, ZnO-CdS composite powders synthesized by a simple chemical precipitation method were thoroughly characterized. The morphological, structural, compositional, photocatalytical, and biological properties of the prepared composites investigated in comparison with those pristine components correlated CdS concentration. contain flower-like structures, their size being tuned amount added during synthesis. photocatalytic activity was analyzed under UV irradiation using impregnated...
Due to the fact of their ability bond with human’s hard tissue, bioglasses have gained interest in biomedical field certain purposes regarding usage replacement, healing or repair bones. In form thin films, they trigger an increase biocompatibility for inert supports after implantation, based on surface engineering ensure osteoinduction. For that, this research is focused obtaining coatings cerium-enriched bioglass generate bioactive and potential additional antimicrobial antioxidant...
Complexes with mixed ligands [Cu(N-N)2(pmtp)](ClO4)2 ((1) N-N: 2,2′-bipyridine; (2) L: 1,10-phenanthroline and pmpt: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesized structurally biologically characterized. Compound (1) crystallizes into space group Pa in P-1. Both complexes display an intermediate stereochemistry between the two five-coordinated ones. The biological tests indicated that compounds exhibited superoxide scavenging capacity, intercalative DNA properties,...
A series of five novel copper(II) complexes with imidazole derivatives having general core Cu(R-Im)
The phyto-development of nanomaterials is one the main challenges for scientists today, as it offers unusual properties and multifunctionality. originality our paper lies in study new materials based on biomimicking lipid bilayers loaded with chlorophyll, chitosan, turmeric-generated nano-silver/silver chloride particles. These showed a good free radical scavenging capacity between 76.25 93.26% (in vitro tested through chemiluminescence method) antimicrobial activity against Enterococcus...
The purpose of this work was to propose and evaluate a new composition for bioactive glass-ceramic starting from the well-known 45S5 commercial product. Thus, we developed modified version, including MgO, an oxide that turned out induce superior mechanical properties improved biological response. This had following molar percentages: 46.1% SiO2, 2.6% P2O5, 16.9% CaO, 10.0% 24.4% Na2O. precursor alkoxides nitrates were processed by standard sol-gel technique, resulting in target, suitable...
Antimicrobial peptides are molecules synthetized by a large variety of organisms as an innate defense against pathogens. These natural compounds have been identified promising alternatives to widely used treat infections and cancer cells. could be viewed future chemotherapeutic alternatives, having the advantage low propensity drug resistance. In this study, we evaluated efficiency antimicrobial peptide gramicidin A (GA) anticancer drug, doxorubicin (Doxo) spheroids from colorectal cells...
Novel complexes of type [Cu(N-N)(dmtp)
To improve their biological activity, complexes [Cu(bipy)(dmtp)2(OH2)](ClO4)2·dmtp (1) and [Cu(phen)(dmtp)2(OH2)](ClO4)2·dmtp (2) (bipy 2,2'-bipyridine, phen: 1,10-phenantroline, dmtp: 5,7-dimethyl-1,2,4-triazolo [1,5-a]pyrimidine) were included in β-cyclodextrins (β-CD). During the inclusion, co-crystalized dmtp molecule was lost, UV-Vis spectra together with docking studies indicated synthesis of new materials 1:1 1:2 molar ratios between β-CD. The association Cu(II) compounds β-CD has...