A5055272589- Receptor Mechanisms and Signaling
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Heme Oxygenase-1 and Carbon Monoxide
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemophilia Treatment and Research
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Eicosanoids and Hypertension Pharmacology
- Ion channel regulation and function
- Urinary Bladder and Prostate Research
- Bone health and osteoporosis research
- High Altitude and Hypoxia
- Glycogen Storage Diseases and Myoclonus
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hormonal and reproductive studies
- Analytical Chemistry and Chromatography
- Peripheral Neuropathies and Disorders
- Vitamin K Research Studies
- Molecular Sensors and Ion Detection
- Nitric Oxide and Endothelin Effects
- Cerebrovascular and genetic disorders
- Multiple Sclerosis Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
Kanazawa University
2008-2024
National Cerebral and Cardiovascular Center
2002-2024
Oita University of Nursing and Health Sciences
2024
Bristol-Myers Squibb (Japan)
2020
Shibaura Institute of Technology
2017
Tokushima University
2014-2015
Tokyo Women's Medical University
2012
Shinshu University
1987-2009
Niigata University of Health and Welfare
2009
Suwa Red Cross Hospital
1995-2004
Dysmenorrhea is a common menstrual disorder experienced by adolescents, and its major symptoms, including pain, adversely affect daily life school performance. However, little epidemiologic evidence on dysmenorrhea in Japanese adolescents exists. This cross-sectional study aimed to determine the prevalence of identify factors associated with female junior high students. Among 1,167 girls aged between 12 15 years, 1,018 participants completed questionnaire that solicited information age at...
Using immunohistochemical staining methods with antibodies to amyloid beta protein and human cystatin C, we examined cerebrovascular in the brains from 46 cases cerebral angiopathy (seven Alzheimer's disease, one Down's syndrome, 18 intracranial hemorrhage, 10 infarction, elderly patients without any neurologic disorder). All deposits these were consistently immunoreactive anti-beta antibody. However, nine some vascular walls strong immunoreactivity also reacted less intensely anti-cystatin...
Background and purpose Differential diagnosis of sporadic inclusion body myositis (s‐ IBM ) polymyositis ( PM )/dermatomyositis DM is difficult can affect proper disease management. Detection heterogeneous muscular involvement in s‐ by muscle sonography could be a unique diagnostic feature. Methods Sonography the lower leg forearm was performed patients with , / control subjects n = 11 each). Echo intensities EI s) adjacent muscles [medial head gastrocnemius versus soleus flexor digitorum...
Aim: Obstructive sleep apnea syndrome (OSAS) has been associated with high cardiovascular morbidity and mortality, patients suffer from repeated episodes of hypoxia. Platelet-derived microparticles (PDMPs) are released via platelet activation by various agonists, including inflammatory cytokines or shear stress. Plasminogen activator inhibitor -1 (PAI-1) is a fibrinolytic marker soluble fibrin (SF) coagulation marker. We examined plasma levels PDMPs, PAI-1 SF in OSAS. also the effects...
This study assessed the specificity of displacement potencies MCI-9042 [+/-)-1-[o-[2-(m-methoxyphenyl)ethyl]phenoxy]-3-(dimethylamino)- 2-propyl hydrogen succinate hydrochloride), a new antiplatelet agent, in [3H]4-bromo-2,5-dimethoxyphenylisopropylamine [( 3H]DOB) and [3H]ketanserin binding to 5HT2-serotonergic receptors rat brain using radioligand method. The assessment its derivative, M-1 [(+/-)-1-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]-3-(dimethylamino)- 2-propanol)hydrochloride), on alpha...
Utilizing an enaminoketone (1) as starting material, 3-substituted chromones were synthesized by the reactions of acid anhydrides derivatives under mild conditions.
Two siblings of a consanguineous marriage showed identical clinical features consisting supranuclear vertical ophthalmoplegia, bradykinesia, rigidity. stooped posture, pseudobulbar palsy, and dementia, all beginning in the sixth decade. There was no history encephalitis or exposure to known chemicals. L-Dopa therapy only partially temporarily effective. Autopsy one patient revealed extensive neurofibrillary degeneration with prominent involvement limbic system. were senile plaques Lewy...
We herein describe the case of a Japanese cerebrotendinous xanthomatosis (CTX) patient with novel CYP27A1 gene mutation. The had been diagnosed cataracts at 25 years age and subsequently developed neurological symptoms in his forties, being referred to our hospital 47 age. Upon admission, Achilles tendon xanthomas, cognitive impairment, dysphagia, dysarthria, dystonia, spasticity, muscle weakness ataxia were observed. Brain MRI revealed abnormal signals dentate nuclei, periventricular white...
Abstract Treatment with immune checkpoint inhibitors has improved prognosis among patients cutaneous melanoma, but there are still unmet medical needs in Japan, especially for mucosal melanoma and acral lentiginous (ALM) subtypes. Ipilimumab, a fully human monoclonal antibody that specifically blocks cytotoxic T‐lymphocyte‐associated antigen 4 potentiates antitumor T‐cell response, was approved Japan 2015 the treatment of radically unresectable malignant melanoma. This postmarketing...
A 64-year-old woman who suffered intractable gastric ulcers with hemorrhaging showed huge submucosal hematomas in her stomach on the endoscopic examination. Since mucosal biopsy revealed amyloid deposition and IgG λ type M protein was detectable serum, she diagnosed as having primary AL systemic amyloidosis. The hemorrhages did not improve despite intensive medication, so total gastrectomy performed, resulting an unfavorable outcome. Massive of immunoreactivity seen vessels stomach. This is...
Very few epidemiologic studies on bone fracture have been conducted in schools for handicapped children (Yogo schools). The aim of this study was to clarify the frequency and risk factors physically disabled Japan.We used a cross-sectional design examine 525 38 Yogo Hokuriku-Koshinetsu District Japan. questionnaire surveyed information participant sex, age, level physical disability, history. Information fractures obtained, including number over lifetime, age when occurred, location, cause....
Protein S (PS) acts as a cofactor for activated protein C in the plasma anticoagulant system. PS Lys196-to-Glu (K196E) mutation is genetic risk factor venous thromboembolism Japanese individuals. Because of substantial overlap activity between KK (wild-type) and KE (heterozygous) genotypes, it difficult to identify K196E carriers by measuring activity. Here, we generated monoclonal antibodies specific mutant developed simple reliable method identification carriers. We immunized mice with...
Abstract Objective Low Ca intake is common among Japanese women, but its effect on bone metabolism has not been fully elucidated. The aim of the present study was to determine relationship between and serum markers turnover in postmenopausal women. Design A cross-sectional study. Setting community setting. Subjects were 595 home-dwelling assessed by a validated FFQ. Serum type I collagen cross-linked N-telopeptides (NTX) osteocalcin measured as turnover. relationships demographic...
Multiple brain tumors of diffuse large B cell lymphoma (DLBL) were observed in a 75-year-old man with Waldenström's macroglobulinemia (WM). Paravertebral and multiple subcutaneous nodules occurred succession he died 4 months after onset. We investigated monoclonality by means polymerase chain reaction (PCR) analysis sequencing the immunoglobulin heavy paraffin-embedded sections. The PCR product showed different rearrangement pattern from those other co-occurrence DLBL WM is rare, some...
The object of this study was to examine the existence and characteristics alpha 1-adrenoceptor subtypes in bovine prostate using radioligand binding assay method. [3H]Prazosin used as its sites were classified into two subtypes. One subtype showed a high affinity (alpha 1High, Kd: 101.1 pM Bmax: 11.8 fmol (mg protein)-1) other had low 1Low, 3371.4 50.5 protein)-1). Although same pKi values clorethylclonidine, p-aminoclonidine, benoxathian dibenamine both 1High 1Low tissue observed, 1...
The circadian rhythms of the toxicity and pharmacokinetics methotrexate (MTX), as well effects manipulation feeding schedule on rhythms, were investigated in mice. Male ICR mice housed under a standardized light-dark cycle (12:12) with food water ad libitum (ALF) or time-restricted (TRF) (8 hr during light phase) for 1 day 14 days before drug administration. animals received MTX (100 mg/kg, i.p.) once daily 7 studies single dose kinetic studies. Under ALF, significant dosing time dependency...