A5057987402- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- COVID-19 and healthcare impacts
- Diversity and Career in Medicine
- Cervical Cancer and HPV Research
- Genetic factors in colorectal cancer
- Histone Deacetylase Inhibitors Research
- Cell death mechanisms and regulation
- Cancer Mechanisms and Therapy
- Dental Education, Practice, Research
- Economic and Financial Impacts of Cancer
- ATP Synthase and ATPases Research
- Endometriosis Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Peptidase Inhibition and Analysis
- Social Media in Health Education
- Cancer survivorship and care
- Colorectal and Anal Carcinomas
- Hernia repair and management
- Monoclonal and Polyclonal Antibodies Research
- Health Literacy and Information Accessibility
- Palliative Care and End-of-Life Issues
- Academic Writing and Publishing
- Trauma and Emergency Care Studies
- Healthcare Policy and Management
Icahn School of Medicine at Mount Sinai
2020-2025
National Cancer Institute
2020-2023
National Institutes of Health
2020-2023
Mount Sinai Hospital
2021-2023
Walter Reed National Military Medical Center
2012-2023
Mount Sinai Hospital
2021-2022
Center for Cancer Research
2016-2020
Brooklyn Hospital Center
2020
Women's Hospital
2020
Nova Medical (United States)
2019
BackgroundThe coronavirus disease 2019 pandemic has resulted in unprecedented challenges for the oncology community. For people living with cancer, treatments are interrupted, surgeries cancelled, and regular evaluations rescheduled. People cancer their physicians must balance plausible fears of treatment consequences delaying care.ObjectiveWe aim to evaluate experience women ovarian during pandemic.Study DesignWomen a current or previous diagnosis completed an online survey focusing on...
The primary goal of this study is to examine disparities in high-risk endometrial cancer (EC) patients relation rates genetic referrals (GR), testing (GT), and counseling (GC). This a retrospective analysis with newly diagnosed EC between January 1, 2014 September 2020 at single institution. Patients were defined as when they 1) 50 years or younger, 2) had positive family history for 3) evidence loss mismatch repair protein expression on tumor immunohistochemistry. Rates GR, GT GC analyzed...
To evaluate the natural history of vaginal intraepithelial neoplasia (VAIN) and to identify risk factors for invasive carcinoma.The records all women with VAIN diagnosed at military treatment facilities over a 10-year period minimum follow-up 12 months were reviewed. Patient demographics clinical information related diagnosis recorded.One hundred twenty-seven met inclusion criteria. The mean age was 47.4 years, median surveillance 34 (range 12-169 months). Seventy-five patients had low-grade...
Background: The COVID-19 pandemic has resulted in unprecedented challenges for people living with cancer, impacting not only physical health but psychological well-being. response affects the individual as well community and can persist long after outbreak. We aim to assess coping strategies employed by women ovarian cancer during pandemic.Methods: Women a current or prior diagnosis of completed an online survey which included query about pandemic. was distributed from March 30th through...
Purpose: Despite high initial response rates with cytoreductive surgery, conventional chemotherapy and the incorporation of biologic agents, ovarian cancer patients often relapse die from their disease. New approaches are needed to improve patient outcomes. This study was designed evaluate antitumor activity NEO-201 in preclinical models where target is highly expressed. Experimental Design: Functional analysis against tumor cell lines performed by ADCC assays. Binding tissues were...
► Gynecologic oncology patients can be exposed to both chronic and acute physical emotional stress. appear represent an at-risk population for the development of Takotsubo's cardiomyopathy.
The overexpression of inhibitor apoptosis (IAP) proteins is strongly related to poor survival women with ovarian cancer. Recurrent cancers resist due the dysregulation IAP proteins. Mechanistically, Second Mitochondrial Activator Caspases (SMAC) mimetics suppress functions restore apoptotic pathways resulting in tumor death. We previously conducted a phase 2 clinical trial single-agent SMAC mimetic birinapant and observed minimal drug response recurrent cancer despite demonstrating on-target...
Uterine leiomyosarcoma in a prior myomectomy site is rare phenomenon. We report an unusual case of arising six months post 16-year old female.
Inhibitor of apoptosis (IAP) proteins are frequently upregulated in ovarian cancer, resulting the evasion and enhanced cellular survival. Birinapant, a synthetic second mitochondrial activator caspases (SMAC) mimetic, suppresses functions IAP order to enhance apoptotic pathways facilitate tumor death. Despite on-target activity, however, pre-clinical trials single-agent birinapant have exhibited minimal activity recurrent cancer setting. To augment therapeutic potential birinapant, we...
Abstract Objectives: We have developed a novel humanized IgG1 monocolonal antibody, NEO-201, which targets neoantigen expressed on ovarian and GI malignancies. This antigen has homology to CEACAM; however, it specificity tumor tissues not normal tissues. Our aims were as follows: (1) evaluate the expression of this cell lines derived from various cancers; (2) determine functionality NEO-201. Methods: Expression was identified by western blot analysis flow cytometry. Functionality determined...
Social media outlets have increased in popularity within the last decade and are influencing ways which patients interact with healthcare system. The objective of this study is to examine presence gynecologic oncology divisions on Instagram analyze content their posts. Secondary objectives included examining analyzing use as a tool for patient education among people at genetic risk cancers. Seventy-one NCI-Designated Cancer Centers, hereditary cancer related posts were searched Instagram....
The primary goal of this study is to examine disparities in high-risk endometrial cancer (EC) patients relation rates genetic referrals (GR), testing (GT), and counseling (GC).This a retrospective analysis with newly diagnosed EC between January 1, 2014 September 2020 at single institution. Patients were defined as when they 1) 50 years or younger, 2) had positive family history for 3) evidence loss mismatch repair protein expression on tumor immunohistochemistry. Rates GR, GT GC analyzed...
Chescheir, Nancy C. MD; Zeligs, Kristen P. Easter, Sarah Rae Evans, Megan L. MD, MPH Author Information
e17599 Background: While it is well established that age of diagnosis impacts survival in patients with certain types cancer including breast, colon and prostate, this has yet to be explored ovarian cancer. The aim study was examine relation oncologic treatment, prognosis, surgical outcomes. Methods: All diagnosed between the dates January 1, 2014 December 31, 2022 who underwent staging at a single institution were identified. Clinicopathological follow-up data extracted from patient’s...