A5034143675- Atherosclerosis and Cardiovascular Diseases
- Single-cell and spatial transcriptomics
- Angiogenesis and VEGF in Cancer
- Anesthesia and Sedative Agents
- Healthcare Decision-Making and Restraints
- Congenital Diaphragmatic Hernia Studies
- Anesthesia and Neurotoxicity Research
- Immune cells in cancer
- Ethics and Legal Issues in Pediatric Healthcare
- Tracheal and airway disorders
- Intensive Care Unit Cognitive Disorders
- Emergency and Acute Care Studies
- Esophageal and GI Pathology
Harvard University
2019-2024
Hadassah Medical Center
2021
Massachusetts Institute of Technology
2019
Broad Institute
2019
Background: The cells that form the arterial wall contribute to multiple vascular diseases. extent of cellular heterogeneity within these populations has not been fully characterized. Recent advances in single-cell RNA-sequencing make it possible identify and characterize subpopulations. Methods: We validate a method for generating droplet-based atlas gene expression normal blood vessel. Enzymatic dissociation 4 whole mouse aortas was followed by sequencing >10 000 cells. Results:...
BACKGROUND Reduction of physical restraint utilization is a goal high-quality hospital care, but there little nationally-representative data about in hospitalized children the United States. This study reports rate coding among hospitalizations for patients aged 1 to 18 years old States and explores associated demographic diagnostic factors. METHODS The Kids’ Inpatient Database, an all-payors database community discharges States, was queried with diagnosis status 2019. Logistic regression...
Endothelial cells (ECs) are capable of quickly responding in a coordinated manner to wide array stresses maintain vascular homeostasis. Loss EC cellular adaptation may be potential marker for cardiovascular disease and predictor poor response endovascular pharmacological interventions such as drug-eluting stents. Here, we report single-cell transcriptional profiling ECs exposed multiple stimulus classes evaluate adaptation.
Delirium is an acute neuropsychiatric condition associated with increased morbidity and mortality. There increasing recognition of delirium as a substantial health burden in younger patients, although few studies have characterized its occurrence. This study analyzes the occurrence diagnosis, comorbidities, cost among youth hospitalized United States.
Central MessageDiaphragmatic herniation may occur after esophagectomy and liver resection. We describe the management of fecopneumothorax secondary to a diaphragmatic defect caused by mobilization.See Commentaries on pages 92 94.Clinical SummaryA 65-year-old woman underwent neoadjuvant chemoradiation minimally invasive Ivor-Lewis (MIE) for esophageal adenocarcinoma. A restaging positron emission tomography scan showed regression tumor avidity no metastasis. Nevertheless, during her MIE, 3-cm...