A5058411389- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Sulfur Compounds in Biology
- Zebrafish Biomedical Research Applications
- Polymer Science and PVC
- Nitric Oxide and Endothelin Effects
- Biochemical Acid Research Studies
- Biochemical effects in animals
- Recycling and Waste Management Techniques
- Polyamine Metabolism and Applications
- Biopolymer Synthesis and Applications
- GABA and Rice Research
- Phosphodiesterase function and regulation
- Neurotransmitter Receptor Influence on Behavior
- Ion channel regulation and function
- Diet and metabolism studies
- Chemical Reactions and Isotopes
- Organic and Inorganic Chemical Reactions
- Neurogenesis and neuroplasticity mechanisms
- Alcoholism and Thiamine Deficiency
- Analytical Chemistry and Chromatography
- Neuroscience and Neural Engineering
- Gut microbiota and health
Aarhus University
2022-2025
Northwestern University
2015-2024
Albert Einstein College of Medicine
2024
The University of Tokyo
1988-2017
Tokyo Medical University
2011
Osaka University
2009
National Institute of Health Sciences
1979-1988
The Ohio State University
1966
An increase in the ratio of cellular excitation to inhibition (E/I ratio) has been proposed underlie pathogenesis neuropsychiatric disorders, such as autism spectrum disorders (ASD), obsessive-compulsive disorder (OCD), and Tourette's syndrome (TS). A proper E/I is achieved via factors expressed neuron glia. In astrocytes, glutamate transporter GLT1 critical for regulating an ratio. However, role dysfunction remains unknown because mice with a complete deficiency exhibited seizures premature...
Elimination of early-formed redundant synapses during postnatal development is essential for functional neural circuit formation. Purkinje cells (PCs) in the neonatal cerebellum are innervated by multiple climbing fibers (CFs). A single CF strengthened whereas other CFs eliminated each PC dependent on postsynaptic activity PC, but underlying mechanisms largely unknown. Here, we report that brain-derived neurotrophic factor (BDNF) from facilitates synapse elimination. By PC-specific deletion...
2-Arachidonoylglycerol (2-AG) is the endocannabinoid that mediates retrograde suppression of neurotransmission in brain. In present study, we investigated 2-AG signaling system at mossy cell (MC)–granule (GC) synapses mouse dentate gyrus, an excitatory recurrent circuit where endocannabinoids are thought to suppress epileptogenesis. First, showed by electrophysiology produced diacylglycerol lipase α (DGLα) mediated both depolarization-induced excitation and its enhancement group I...
Key points 2‐Arachidonoylglycerol (2‐AG), one of the best‐characterized retrograde messengers at central synapses, has been thought to be produced ‘on demand’ through a diacylglycerol lipase α (DGLα)‐dependent pathway upon activation postsynaptic neurons (on‐demand synthesis hypothesis). However, recent studies propose an alternative hypothesis that 2‐AG is pre‐synthesized by DGLα, stored in neurons, and released from such ‘pre‐formed pools’ without participation DGLα (pre‐formed pool To...
Abstract Intracellular trafficking of receptor proteins is essential for neurons to detect various extracellular factors during the formation and refinement neural circuits. However, precise mechanisms underlying neurotrophin receptors synapses remain elusive. Here, we demonstrate that a brain-enriched sorting nexin, ARHGAP33, new type regulator intracellular TrkB, high-affinity brain-derived neurotrophic factor. ARHGAP33 knockout (KO) mice exhibit reduced expression synaptic impaired spine...
The claustrum complex is viewed as fundamental for higher order cognition; however, the circuit organization and function of its neuroanatomical subregions are not well understood. We demonstrated that some key roles CLA can be attributed to connectivity a small group neurons in ventral subregion, endopiriform (EN). identified subpopulation EN by their projection CA1 (EN vCA1-proj. neurons), embedded recurrent circuits with other piriform cortex. Although neuron activity was biased toward...
The claustrum complex is viewed as fundamental for higher-order cognition; however, the circuit organization and function of its neuroanatomical subregions are not well understood. We demonstrated that some key roles CLA can be attributed to connectivity a small group neurons in ventral subregion, endopiriform (EN). identified subpopulation EN by their projection CA1 (EN vCA1-proj . neurons), embedded recurrent circuits with other piriform cortex. Although vCA1-proj. neuron activity was...
The endocannabinoid 2-arachidonoylglycerol (2-AG) mediates retrograde synaptic suppression. Although the mechanisms of 2-AG production are well characterized, how is degraded less clearly understood. Here we found that expression hydrolyzing enzyme monoacylglycerol lipase (MGL) was highly heterogeneous in cerebellum, being rich within parallel fiber (PF) terminals, weak Bergman glia (BG), and absent other terminals. Despite this selective MGL pattern, 2-AG–mediated suppression significantly...
Experience-driven plasticity of glutamatergic synapses on striatal spiny projection neurons (SPNs) is thought to be essential goal-directed behavior and habit formation. One major form plasticity, long-term depression (LTD), has long appeared expressed only pre-synaptically. Contrary this view, nitric oxide (NO) generated by interneurons was found induce a post-synaptically LTD at SPN synapses. This dependent signaling through guanylyl cyclase protein kinase G, both which are abundantly...
Huntington's disease (HD) is a neurodegenerative disorder characterized by deficits in movement control that are widely viewed as stemming from pathophysiological changes the striatum. Giant, aspiny cholinergic interneurons (ChIs) key elements striatal circuitry controlling movement, but whether their physiological properties intact HD brain unclear. To address this issue, synaptic of ChIs were examined using optogenetic approaches Q175 mouse model HD. In ex vivo slices, facilitation at...
Abstract Background The network pathophysiology underlying the motor symptoms of Parkinson's disease (PD) is poorly understood. In models late‐stage PD, there significant cell‐specific remodeling corticostriatal, axospinous glutamatergic synapses on principal spiny projection neurons (SPNs). Neurons in centrolateral nucleus (CLN) thalamus that relay cerebellar activity to striatum also make SPNs, but extent which they are affected PD has not been definitively characterized. Objective To fill...