A5027166299- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Phytochemistry and Bioactive Compounds
- Phytochemical Studies and Bioactivities
- Plant-based Medicinal Research
- Polysaccharides and Plant Cell Walls
- Ginseng Biological Effects and Applications
- Medicinal Plant Pharmacodynamics Research
- Autophagy in Disease and Therapy
- Natural Compounds in Disease Treatment
- Nephrotoxicity and Medicinal Plants
- Healthcare and Venom Research
- Medicinal Plants and Neuroprotection
- Phytochemical compounds biological activities
- Enhanced Recovery After Surgery
- Exercise and Physiological Responses
- Mycobacterium research and diagnosis
- Molecular Sensors and Ion Detection
- Bioactive Compounds in Plants
- Sesquiterpenes and Asteraceae Studies
- Signaling Pathways in Disease
- Cardiac Fibrosis and Remodeling
- Phytochemicals and Medicinal Plants
- Glycosylation and Glycoproteins Research
Pingdingshan University
2022-2025
First Affiliated Hospital of Jinan University
2020-2022
Fuyang Second People's Hospital
2022
Jinan University
2020
Shenyang Pharmaceutical University
2018-2019
Background: Apoptosis and autophagy are two important patterns of cell death in the process heart failure. Qi-Li-Qiang-Xin (QLQX), a traditional Chinese medicine, has been frequently used treatment chronic failure (CHF) China. However, potential effect QLQX on not reported. In this study, we aimed to investigate whether alleviated isoproterenol (ISO)-induced myocardial injury through regulating autophagy. Methods: The rapid identification chemical ingredients was performed by UPLC-Q-TOF-MS,...
Abstract Fuziline, an aminoalcohol‐diterpenoid alkaloid derived from Aconiti lateralis radix preparata, has been reported to have a cardioprotective activity in vitro. However, the potential mechanism of fuziline on myocardial protection remains unknown. In this study, we aimed explore efficacy and isoproterenol (ISO)‐induced injury vitro vivo. As result, effectively increased cell viability alleviated ISO‐induced apoptosis. Meanwhile, significantly decreased production ROS, maintained...
<title>Abstract</title> Peony pods, as a byproduct of peony seeds, are often discarded. This study aimed to explore the effect and mechanism pods extract (PPE) for treating premature ovarian failure (POF) by UPLC-Q-TOF/MS method combined with network pharmacology <italic>in vivo</italic> experimental validation. Firstly, total 26 components PPE were detected analysis. Subsequently, cisplatin was used construct POF model, treatment could significantly improve index, estrous cycle structure...
Alismatis rhizoma (AR), a distinguished diuretic traditional Chinese herbal medicine, is widely used for the treatment of diarrhea, edema, nephropathy, hyperlipidemia, and tumors in clinical settings. Most beneficial effects AR are attributed to major triterpenoids, whose contents relatively high AR. To date, only 25 triterpenoids have been characterized by LC-MS because low-mass diagnostic ions hardly triggered MS, impeding structural identification. Herein, we developed an advanced data...
In the present study, a specific and sensitive approach using ultra-high-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry was developed validated for quantitative analysis of 14 constituents in rat plasma, liver, heart. The method fully successfully applied to pharmacokinetic, hepatic disposition, heart tissue distribution studies compounds after oral administration Qi-Li-Qiang-Xin capsule. Ginsenoside Rb1, alisol A, astragaloside IV, periplocymarin...
Paeoniflorin (PAE) is the main active compound of Radix Paeoniae Rubra (a valuable traditional Chinese medicine and a dietary supplement) exerts beneficial effects on female reproductive function. However, actions PAE diminished ovarian reserve (DOR, very common function disorder) are still unclear. Herein, our study investigated effect potential mechanism DOR by using cisplatin-induced mice functional impairment estradiol (E2) synthesis granulosa-like KGN cells. Our data show that improved...
Codonopsis radix was commonly used as food materials or herbal medicines in many countries. However, the comprehensive analysis of chemical constituents, and vivo xenobiotics remain unclear. In present study, an integrated strategy with feature-based molecular networking using ultra-high-performance liquid chromatography coupled mass spectrometry established to systematically screen constituents radix. A step-by-step manner based on a composition database, visual structure classification,...
Cysteine (Cys), one of the important participants in protecting cells from oxidative stress, is closely associated with occurrence and development various diseases. Moreover, cell viscosity as a pivotal microenvironmental parameter has recently attracted increasing attention due to its dominant role governing intracellular signal transduction diffusion reactive metabolites. Thus, simultaneous detection Cys imperative for investigating their pathophysiological functions cross-link. Herein we...
Pathological cardiac hypertrophy is the most important risk factor for developing chronic heart failure. Therefore, discovery of novel agents treating pathological remains urgent. In present study, we examined therapeutic effect and mechanism periplocymarin (PM)-mediated protection against using angiotensinII (AngII)-stimulated in H9c2 cells transverse aortic constriction (TAC)-induced mice. vitro, PM treatment significantly reduced surface area expressions hypertrophy-related proteins....
Mori Fructus (MF) is a famous edible fruit of Morus alba L. as well traditional Chinese medicine (TCM). Moreover, exposure behavior complex components in vivo necessary way to elucidate active substances TCMs. However, the effective discovery ingredients from MF still challenge for researchers. In this study, an integrated strategy with chemical characterization, metabolism, isolation, and activity evaluation was established applied targeted potential lipid-lowering MF. First,...
An efficient strategy for the identification of potential nephroprotective substances in Zhu‐Ling decoction has been established with integration absorbed components characterization, pharmacokinetics, and activity evaluation. A qualitative method was developed to characterize chemical constituents vivo by using ultra‐performance liquid chromatography‐quadrupole‐time‐of‐flight mass spectrometry. quantitative validated simultaneous determination eight compounds rat plasma...
Allii Macrostemonis Bulbus is also named Xiebai in China. It an edible vegetable, and a famous herb for treating coronary heart disease. Allium chinense G. Don (ACGD) macrostemon Bunge (AMB) are it botanical sources. The aim of this study was to explore the cardioprotective effects, decipher visual spatial distribution absolute content primary metabolites derived from these two herbs.
A series of C21 steroidal glycosides were isolated from the root bark Periploca sepium, including a new compound, perisepiumoside A1 (1), and six known compounds (2-7). Their structures elucidated by analysis HR-ESI-MS, 1D 2D NMR spectroscopic data. All these tested for their NO production inhibitory activity in LPS-stimulated RAW 264.7 cells. Results showed that could remarkably inhibit production, particularly 1 2 with IC50 values 30.81 ± 0.18 μM 44.39 0.21 μM, respectively. In addition,...