A5102929104- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- interferon and immune responses
- Retinal and Macular Surgery
- Metal complexes synthesis and properties
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Adenosine and Purinergic Signaling
- Ferroptosis and cancer prognosis
- Environmental Toxicology and Ecotoxicology
- Synthesis and Characterization of Heterocyclic Compounds
- Urinary Bladder and Prostate Research
- Inflammasome and immune disorders
- Glaucoma and retinal disorders
- Plant Molecular Biology Research
- Vascular Malformations Diagnosis and Treatment
- Retinal Development and Disorders
- Immune cells in cancer
- Synthesis and biological activity
- Metal-Organic Frameworks: Synthesis and Applications
- Immune responses and vaccinations
- AI and Big Data Applications
- Synthesis and Biological Evaluation
- Medicinal Plant Pharmacodynamics Research
- Tannin, Tannase and Anticancer Activities
Nanjing Medical University
2015-2025
Wuxi People's Hospital
2017-2025
Pingdingshan University
2016-2025
Jiangnan University
2025
Jiangsu Province Hospital
2015-2021
Southwest University of Science and Technology
2021
Hefei University of Technology
2019-2020
Zhongda Hospital Southeast University
2018
Institute of Clinical Research
2018
Tongji Hospital
2018
Diabetic retinopathy (DR) is a well-known microvascular complication related to inflammation. Mcc950 potent and specific inhibitor of the NLRP3 inflammasome but its influence on DR has not been studied. Thus, we evaluated anti-inflammatory effects high-glucose-induced human retinal endothelial cells (HRECs) potential underlying mechanism. In surgical excised proliferative membranes from patients, high expression NLRP3, caspase 1 IL-1β was observed co-localization occurred in CD31+ labeled...
Retinal pigment epithelium (RPE) cell damage is implicated in the pathogenesis of age-related macular degeneration (AMD). An increase interferon-γ (IFN-γ) levels was observed patients with AMD, but whether inflammatory factors are causally related to AMD progression unclear. Here, we demonstrate a direct causal relationship between IFN-γ and RPE death. induced human retinal epithelial (ARPE-19) death accompanied by increases Fe2+ , reactive oxygen species, lipid peroxidation, glutathione...
Abstract Background Kidney cancer’s incidence and mortality vary in different regions countries. To compare interpret kidney burden change trends the globe countries, we conducted this study to report global cancer attributable risk factors. Methods Data about incidence, death, disability-adjusted life-year (DALY) were extracted from Global Burden of Diseases 2017. Besides, social-demographic index (SDI) values adopted investigate correlation between social development degrees. Results In...
Background: Diabetic retinopathy (DR) is one of the most important microvascular diseases diabetes. Our previous research demonstrated that bile acid G-protein-coupled membrane receptor (TGR5), a novel cell acid, ameliorates vascular endothelial dysfunction in DR. However, precise mechanism leading to this alteration remains unknown. Thus, TGR5 progress DR should be urgently explored. Methods: In study, we established high glucose (HG)-induced human retinal cells (RMECs) and...
As a CXC-type chemokine, ENA78/CXCL5 is an important attractant for granulocytes by binding to its receptor CXCR2. Recent studies proved that CXCL5/CXCR2 axis plays oncogenic role in many human cancers. However, the exact clinical significance of CXCL5 lung cancer has not been well defined. Here, we found serum protein expression was significantly increased non-small cell (NSCLC) compared with healthy volunteers. Immunohistochemistry staining revealed higher various tissues normal tissues....
Malignant tumors have become one of the challenges to global human health today, and development new drugs has a research hotspot for tumor treatment. In order prove that copper(II)-thiosemicarbazone complexes can be used as antibacterial antitumor agents, we synthesized characterized three copper(II) (C1-C3). These Cu(II) exhibited excellent anticancer antimicrobial activity, greatly exceed corresponding metal-free ligands. C3 highest anti-proliferative activity (0.20 ± 0.04 µM) against...
Diabetic retinopathy (DR) is widely acknowledged as an ocular complication of diabetes mellitus involving retinal inflammation and secondary neuro/microvascular degeneration. Müller glial cells play a crucial role in regulating homeostasis neuroinflammation within the retina. Farnesoid X nuclear receptor (FXR) has emerged potential regulator metabolic inflammatory responses bile acid receptor. However, its precise DR remains unclear. In order to investigate effect FXR on DR, we employed...
We have prepared six thiosemicarbazone ligands and synthesized the corresponding Ga(iii) complexes. The antitumor activity of ligand increases with its lipophilicity, complexes is affected by ligands. Since C6 has highest anticancer proliferative (0.14 ± 0.01 μM) against HepG-2 (Human hepatocarcinoma cell line), we characterized structure X-ray single crystal diffraction explored antiproliferation mechanism. Anti-tumor mechanism results show that complex (C6) promoted cycle arrest in G1...
Purpose: Epithelial cell transforming sequence 2 (ECT2) is a guanine nucleotide exchange factor, which involved in division regulation and cycle modulation. Recent evidence indicates that ECT2 overexpressed many human cancers. However, the exact prognostic value of lung cancer has not been elucidated. Patients methods: In current study, we performed correlation prognosis analyses using public databases conducted immunohistochemical staining tissue microarrays, samples from 204 patients with...
Cysteine (Cys), one of the important participants in protecting cells from oxidative stress, is closely associated with occurrence and development various diseases. Moreover, cell viscosity as a pivotal microenvironmental parameter has recently attracted increasing attention due to its dominant role governing intracellular signal transduction diffusion reactive metabolites. Thus, simultaneous detection Cys imperative for investigating their pathophysiological functions cross-link. Herein we...
Soil salinity is a widespread stress in semi-arid forests worldwide, but how to manage nitrogen (N) nutrition improve plant saline tolerance remains unclear. Here, the cuttings of widely distributed poplar from central Asia, Populus russikki Jabl., were exposed either normal or low (LN) concentrations for two weeks semi-controlled greenhouse, and then they added with moderate salt solution not another evaluate their physiological, biochemical, metabolites transcriptomic profile changes....
Oral cancer is a common malignancy with high mortality rate. Although surgery the best treatment option for patients cancer, this approach ineffective advanced metastases. Molecular agents are irreplaceable in preventing and treating distant This review aims to summarise molecular used of oral last decade describe their sources curative effects. These classified into phenols, isothiocyanates, anthraquinones, statins, flavonoids, terpenoids, steroids. The mechanisms action these include...
A facile and efficient approach to the synthesis of 1,2,5-trisubstituted imidazoles is developed via a multicomponent reaction under metal-free catalysis. Under Brønsted acid catalysis, desired products can be obtained from readily available vinyl azides, aromatic aldehydes, amines without generating any toxic waste. The convenient operations high functional group compatibility indicate that this offers an attractive alternative method for imidazole derivatives.
Chinese government is trying to use the Public-Private Partnership (PPP) help development of China’s elderly care industry. This article will analyze characteristics pension PPP projects, summarize current status projects and existing problems, make some suggestions for these problems. Firstly, reviews literature then introduces common types PPPs, analyzes 107 service in project management library Ministry Finance’s Center. Finally, it proposes problems made suggestions. The results this...