A5102891656- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Tracheal and airway disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Adolescent and Pediatric Healthcare
- Urological Disorders and Treatments
- Ubiquitin and proteasome pathways
- Environmental Science and Water Management
- Cell death mechanisms and regulation
- Esophageal Cancer Research and Treatment
- Congenital gastrointestinal and neural anomalies
- Renal and related cancers
- Intestinal Malrotation and Obstruction Disorders
- Genetic and Kidney Cyst Diseases
- Congenital Anomalies and Fetal Surgery
- Cancer-related Molecular Pathways
- Cleft Lip and Palate Research
- Circular RNAs in diseases
- Gallbladder and Bile Duct Disorders
- Gut microbiota and health
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Pediatric health and respiratory diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
China Medical University
2010-2023
Sheng Jing Hospital
2012
The aims of this study were to identify the mutation gene a Chinese family with anorectal malformation (ARM) associated split hand-foot and determine spatiotemporal expression mutated during hindgut anorectum development in human embryos.A intrafamilial clinically variable manifestation was analyzed primers designed for exons 3-14 P63, DLX5, DLX6, DAC, HOXD13 as candidate genes direct sequence analysis performed. Immunohistochemical embryos 4th-10th weeks performed.Affected individuals found...
To evaluate the outcomes of jejunal turnover and bowel plication (JTBP) in high atresia neonates.The clinical data neonates met criteria were retrospectively analyzed from January 2012 to December 2021.The divided into JTBP group control according surgical procedure.Demographics, postoperative morphology duodenum proximal jejunum,intestinal recovery time complications compared.75 patients allocated (n=30) (n=45) groups, respectively. There was no significant difference between two groups...
Abstract Background and Aims Natural killer (NK) cells play an important role in biliary atresia (BA) pathogenesis; human poliovirus receptor (PVR) is NK‐cell modulator. Here, we explored the of PVR BA pathogenesis. Methods Poliovirus expression NK cell‐associated genes were detected samples a rotavirus‐induced mouse model using quantitative PCR immunofluorescence staining. Chemically modified small interfering RNA silenced model, its effects on population function intrahepatic investigated...
Objective To explore a predisposing gene research platform for congenital malformations in mice caused by transplacental RNAi-EphB2. Methods The EphB2 down-regulatory plasmid SiEphB2 and vector Ringer's solution were delivered into tail vein of 9.5 days pregnancy. Plasmids SiRNA contained three different sites RNAi silencing gene. The embryos removed 48 h after injection real-time quantitative polymerase chain reaction(PCR) Western blot used detecting the expression EphB2. anorectal...
Objective To investigate the formation and proportion of short-chain fatty acids (SCFA) in normal functional constipation (FC) children.Methods Fifty children were divided into control group (15) FC (35).SCFA extracted from children's stool, quantitatively analyzed by gas chromatography (GC).Results Of group, SCFA stool was 51.89±17.62 (mg/g);among SCFA, acetic acid richest, butyric second followed propanoic third, isobutyric fourth, isopentoic last.Compared with significantly decreased;...
Objective To investigate the pattern of bowel habits in normal children North China. Methods A screening program for was carried out 5 northern cities (Beijing, Tianjin, Shenyang, Changchun and Harbin) Random clustered sampling inhabitants under stratification city, zone school or nursery. Totally, 20000 questionnaires were distributed 19638 retrieved. According to self-decided exclusive-criteria, range healthy established. Among investigated, 15652 met criteria children. Frequency,...
The epithelial-mesenchymal transition(EMT)is important for generating multiple tissues during organismal development.This process is particularly essential the gastrulation of metazoans and neural crest delamination vertebrates.EMT could be induced by environmental factors, identifing underlying mechanisms EMT factors indicating a precise role in embryonic stem cells, characterizing relationship between ESCs, Which might contribute pathogenesis genetic diseases congenital...