A5057909592- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Lysosomal Storage Disorders Research
- Carbohydrate Chemistry and Synthesis
- Cancer Cells and Metastasis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genomics and Phylogenetic Studies
- Cellular Mechanics and Interactions
- Ubiquitin and proteasome pathways
- Hematological disorders and diagnostics
- Systemic Lupus Erythematosus Research
- Endometriosis Research and Treatment
- Systemic Sclerosis and Related Diseases
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Proteoglycans and glycosaminoglycans research
- Melanoma and MAPK Pathways
- Peptidase Inhibition and Analysis
Universidade Nova de Lisboa
2015-2022
Hospital de Santo António
2022
Université de Technologie de Compiègne
2021
Centre National de la Recherche Scientifique
2021
Hospital Clínic de Barcelona
2021
University of Bologna
2018-2020
Abstract Cancer-associated glycan structures can be both tumor markers and engines of disease progression. The structure Siaα2,6Galβ1,4GlcNAc (Sia6LacNAc), synthesized by sialyltransferase ST6GAL1, is a cancer-associated glycan. Although ST6GAL1/Sia6LacNAc are often overexpressed in colorectal cancer (CRC), their biological clinical significance remains unclear. To get insights into the relevance ST6GAL1 expression CRC, we interrogated Cancer Genome Atlas with mRNA data hundreds clinically...
Background: The carbohydrate antigen Sda and its biosynthetic enzyme B4GALNT2 are highly expressed in normal colonic mucosa but down-regulated to a variable degree colon cancer tissues. Here, we investigated the clinical biological importance of cancer. Methods: Correlations mRNA with data were obtained from Cancer Genome Atlas (TCGA) database; phenotypic transcriptomic changes induced by studied LS174T cells transfected cDNA. Results: TCGA indicate that patients high expression tissues...
Background: The Sda antigen and its biosynthetic enzyme B4GALNT2 are highly expressed in healthy colon but undergo a variable down-regulation cancer. biosynthesis of the malignancy-associated sialyl Lewis x (sLex) normal cancerous is mediated by fucosyltransferase 6 (FUT6) mutually exclusive from that Sda. It thought reduced malignancy associated with high was due to sLex inhibition. Methods: We transfected cell lines SW480 SW620, derived respectively primary tumor metastasis same patient,...
Abstract Background Congenital disorders of glycosylation (CDG) are a growing group rare genetic disorders. The most common CDG is phosphomannomutase 2 (PMM2)-CDG which often has severe clinical presentation and life-limiting consequences. There no approved therapies for this condition. Also, there validated disease-specific quality life (QoL) scales to assess the heterogeneous burden PMM2-CDG presents challenge assessment disease severity impact certain treatment on course disease. Aim...
In lung cancer, the immune cell compartment of tumor-draining lymph nodes (TDLNs) dictate response against tumors. This is predominantly triggered by myeloid antigen-presenting cells (mAPCs) that capture antigens and, if matured, prime anti-tumor-specific T populations. However, clinical role mAPCs infiltrated in TDLN from cancer patients poorly understood. The purpose this study was to adenocarcinoma patients, comparison individuals with non-malignant diseases, using minimally invasive...
The sensitivity of melanoma cells to targeted therapy compounds depends on the tumor microenvironment. Three-dimensional (3D) in vitro coculture systems better reflect native structural architecture tissues and are ideal for investigating cellular interactions modulating cell drugs. Metastatic (MM) (SK-MEL-28 BRAF V600E mutant SK-MEL-2 wt) were cultured as a monolayer (2D) or cocultured 3D dermal equivalents (with fibroblasts) treated with BRAFi (vemurafenib) combined MEK inhibitor (MEKi,...
<b>Introduction:</b> In lung cancer, the immune compartment of tumor-draining lymph nodes (TDLN) undergoes profound modifications. The immunological response is dictated by antigen presenting cells (APCs). If proper matured, APCs may prime anti-tumour specific T-cell populations. However, role in TDLN from cancer patients poorly understood. <b>Objectives:</b> Study myeloid (mAPC) adenocarcinoma and compare them with non-malignant diseases, using minimally invasive methods. <b>Methods:</b>...
Abstract Background Pregnancy in systemic sclerosis (SSc) patients is no more an infrequent event as it used to be, but literature data on pregnancy outcomes women with SSc are scarce. The rate of preterm deliveries and intrauterine growth restriction (IUGR) seems be increased, while the risk miscarriages controversial. Moreover, study compared antiphospholipid syndrome (APS) lupus erythematosus (SLE). We performed a retrospective compare disease cohort age-matched (SLE), healthy controls...