Platelet concentrates such as platelet-rich plasma, fibrin or concentrated growth factors are cost-effective autologous preparations containing various factors, including platelet-derived factor, transforming factor β, insulin-like 1 and vascular endothelial factor. For this reason, they often used in regenerative medicine to treat wounds, nerve damage well cartilage bone defects. Unfortunately, after administration, these release very quickly, which lose their activity rapidly. As a...

In this study, the antibacterial, cytotoxic and antiproliferative activities of novel thiosemicarbazide derivatives were assessed. Our results demonstrated that some compounds possess good antibacterial properties against Staphylococcus epidermidis, Streptococcus mutans Streptococcussanguinis are only slightly cytotoxic; thus, they exhibit an excellent therapeutic index, which is higher than ethacridine lactate. Moreover, our data showed 2 4 have activity human breast adenocarcinoma...

Abstract Alzheimer’s disease (AD) is by far the most prevalent of all known forms dementia. Despite wide-spread research, main causes emergence and development AD have not been fully recognized. Natural, low-molecular, lipophilic terpenoids constitute an interesting group secondary plant metabolites, that exert biological activities possible use in prevention treatment AD. In order to identify metabolites possessing both antioxidant activity potential increase level acetylcholine, selected...

Guided tissue regeneration and guided bone membranes are some of the most common products used for in periodontal dentistry. The main disadvantage commercially available is their lack cell stimulation easy bacterial colonization. aim this work was to design fabricate a new membrane construct composed electrospun poly (D,L-lactic acid)/poly (lactic-co-glycolic acid) fibers sonocoated with layers nanoparticles specific properties, i.e., hydroxyapatite bimetallic nanocomposite zinc...

The aim of this work is to provide a comprehensive set biological tests assess the biomedical potential novel osteochondral scaffolds with methods proposed comply 3Rs principle, focusing here on biphasic Curdlan-based scaffold as promising model biomaterial. In vitro experiments include evaluation cytotoxicity, mutagenicity, and genotoxicity referring ISO standards, assessment viability proliferation human chondrocytes osteoblasts, estimation inflammation after direct contact biomaterials...

Ziel/Aim: Es wurde evaluiert, ob eine Somatostatin-Rezeptor (SSTR)-gerichtete Peptidrezeptor-Radionuklidtherapie (PRRT) die arterielle Entzündungslast beeinflusst.

Background/Objectives: Bicyclic monoterpenes are one of the most common groups secondary plant metabolites found in Nature. Their wide spectrum biological activity can be used prevention and treatment various diseases, including so-called ‘diseases civilization’. potential for synergistic interactions may influence activities more complex mixtures. Methods: This study investigated ability selected bicyclic their binary mixtures to reduce Fe(III) Cu(II) chelate Fe(II) assessed cytotoxic...

The aim of this work was to establish whether novel curdlan-based hydrogels enriched with Ca2+ ions may be considered as potential candidates for dressings, the acceleration skin wound healing. Firstly, biomaterials were allocated evaluation structural and mechanical properties. Subsequently, ability absorb simulated fluid water vapor permeability, well their capacity release calcium ions, evaluated. biocompatibility assessed using normal human fibroblasts. Importantly, main features...

Citral, a common monoterpene found in numerous plants, is an interesting compound that has been shown to have various biological activities. Although it widely distributed nature and there are many studies presenting its activities, anti-neurodegenerative activity, especially under vivo conditions, very poorly understood. Thus, this paper aimed deepen knowledge about citral activity towards factors symptoms of neurodegeneration. To accomplish this, several comprehensive tests were conducted,...

Given the health-beneficial properties of compounds from hop, there is still a growing trend towards developing successful extraction methods with highest yield and also receiving products high added value. The aim this study was to develop efficient method for isolation bioactive Polish “Marynka” hop variety. modified two-step supercritical fluid allowed obtain two samples, namely crude extract (E1), composed α-acids, β-acids, terpene derivatives, as well pure xanthohumol higher than that...

Skin aging is a natural, unavoidable, and complex process caused by oxidative stress. As consequence, it leads to an increase in the activation of extracellular matrix disruption enzymes DNA damage. The search for natural sources that inhibit these mechanisms can be good approach prevent skin aging. purpose our study was evaluate composition flavonoids phenolic acids extracts obtained from flowers, roots, leaves Eutrema japonicum cultivated Poland. Then, resultant were subjected assessment...

Liquid chromatography electrospray ionization tandem mass spectrometric (LC-ESI-MS/MS) qualitative and quantitative analysis of different extracts from the aerial parts roots Alchemilla acutiloba led to identification phenolic acids flavonoids. To best our knowledge, isorhamnetin 3-glucoside, kaempferol 3-rutinoside, narcissoside, naringenin 7-glucoside, 3-O-methylquercetin, naringenin, eriodictyol, rhamnetin, were described for first time in genus. In addition, antioxidant,...

Chronic wounds, among others, are mainly characterized by prolonged inflammation associated with the overproduction of reactive oxygen species and pro-inflammatory cytokines immune cells. As a consequence, this phenomenon hinders or even precludes regeneration process. It is known that biomaterials composed biopolymers can significantly promote process wound healing regeneration. The aim study was to establish whether curdlan-based modified hop compounds be considered as promising candidates...

In light of current knowledge on the role reactive oxygen species and other oxidants in skin diseases, it is clear that oxidative stress facilitates inflammation an important factor involved i.e., acne. Taking into consideration fact some Cotoneaster plants are valuable curatives diseases traditional Asian medicine, we assumed thus far untested C. hsingshangensis hissaricus may be a source substances used diseases. The aim this study was to evaluate antioxidant, anti-inflammatory,...

The optimization and synthesis of new CK2 CK1 inhibitors are the basis for development therapeutic strategies treatment cancer neurodegenerative disorders associated with overexpression abnormal functioning these enzymes. Triazole derivatives appear to be especially interesting as potential kinase inhibitors. In this context we synthesized a series 1,2,4-triazolin-5-thione CK1γ antiproliferative activity compounds was assessed against cells: human lung adenocarcinoma (A549), hepatoma...

The aim of this study was to compare the chemical composition, as well antioxidant, anti-inflammatory, antiacne, and cytotoxic activites various extracts

Bacterial infections at the wound site still remain a huge problem for current medicine, as they may lead to development of chronic wounds. In order prevent such infections, there is need use dressings that possess ability inhibit bacterial colonization. this study, three new curdlan-based biomaterials modified with copper ions were fabricated via simple and inexpensive procedure, their structural, physicochemical, biological properties in vitro evaluated. Received possessed porous...

The purpose of this study was to make an initial assessment new PEG (polyethylene glycol)-functionalized C60 fullerene derivative for potential bone tissue engineering applications. Thus, Fourier Transform Infrared spectroscopy analysis, thermogravimetric and cyclic voltammetry measurement were performed. Moreover, cell culture experiments in vitro carried out using normal human osteoblasts. Cell viability proliferation evaluated colorimetric...

The purpose of this pilot study was to establish whether a novel freeze-dried curdlan/whey protein isolate-based biomaterial may be taken into consideration as potential scaffold for matrix-associated autologous chondrocyte transplantation. For reason, initially characterized by the visualization its micro- and macrostructures well evaluation mechanical stability, ability undergo enzymatic degradation in vitro. Subsequently, cytocompatibility towards human chondrocytes (isolated from an...