A5037126997- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- Analytical Chemistry and Chromatography
- Advanced Polymer Synthesis and Characterization
- Innovative Microfluidic and Catalytic Techniques Innovation
- Additive Manufacturing and 3D Printing Technologies
- Surfactants and Colloidal Systems
- Adrenal and Paraganglionic Tumors
- Graphene and Nanomaterials Applications
- Nerve injury and regeneration
- Advanced Drug Delivery Systems
- Crystallization and Solubility Studies
- Synthesis and properties of polymers
- Neurogenesis and neuroplasticity mechanisms
- Drug Solubulity and Delivery Systems
- Nanofabrication and Lithography Techniques
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Chemical Synthesis and Analysis
- Advancements in Transdermal Drug Delivery
- Supramolecular Chemistry and Complexes
- Multiple Myeloma Research and Treatments
- biodegradable polymer synthesis and properties
- Porphyrin and Phthalocyanine Chemistry
Universitätsklinikum Würzburg
2022-2024
Klinik und Poliklinik für Augenheilkunde Universitätsklinikum Regensburg
2023
University of Würzburg
2017-2022
Institute of Molecular Functional Materials
2021
Bavarian Polymer Institute
2017-2020
Bahauddin Zakariya University
2017-2018
Polymer micelles offer the possibility to create a nanoscopic environment that is distinct from bulk phase. They find applications in catalysis, drug delivery, cleaning, etc. Often, one simply distinguishes between hydrophilic and hydrophobic, but fine-tuning of microenvironment possible by adjusting structure polymer amphiphile. Here, we investigated small library structurally similar amphiphiles based on poly(2-oxazoline)s poly(2-oxazine)s with respect their solubilization capacity for two...
Despite decades of research, our understanding the molecular interactions between drugs and polymers in drug-loaded polymer micelles does not extend much beyond concepts such as "like-dissolves-like" or hydrophilic/hydrophobic. However, polymer–drug compatibility strongly affects formulation properties therefore translation a into clinics. Specific hydrogen-bonding, π–π stacking, coordination can be utilized to increase drug loading. This is commonly based on trial error eventually leads an...
Polymeric micelles are typically characterized as core–shell structures. The hydrophobic core is considered a depot for molecules, and the corona-forming block acts stabilizing solubilizing interface between aqueous milieu. Tremendous efforts have been made to tune increase drug loading stability of micelles, whereas role hydrophilic blocks rarely investigated in this context, with poly(ethylene glycol) (PEG) being gold standard polymers. To better understand corona, small library...
The aim of the present exploration was to develop novel pH-sensitive cross-linked Gelatin/Polyvinyl pyrrolidone hydrogels using different ratios both polymers and investigate effect degree crosslinking on dynamic, equilibrium swelling invitro release pattern model drug (captopril). Grafting polymerization technique used for preparation these glutaraldehyde as agent. These polymeric materials were then systems envisage various important characterizations like FTIR (Fourier transform infrared...
Introduction: The current work was aimed to design and synthesize novel crosslinked pH-sensitive gelatin/pectin (Ge/Pec) hydrogels using different polymeric ratios explore the effect of polymers degree crosslinking on dynamic, equilibrium swelling in vitro release behavior model drug (Mannitol). Methods: Ge/Pec based were prepared glutaraldehyde as crosslinker. Various structural parameters that affect their determined, including study, porosity, sol-gel analysis, average molecular weight...
Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase the family statins have been suggested as therapeutic options in various tumors. Atorvastatin is a statin with potential to cross blood–brain barrier; however, concentrations necessary for cytotoxic effect against cancer cells exceed achievable via oral administration, which made development novel atorvastatin formulation necessary. We characterized drug loading and basic physicochemical characteristics micellar...
As one kind of "smart" material, thermogelling polymers find applications in biofabrication, drug delivery and regenerative medicine. In this work, we report a thermosensitive poly(2-oxazoline)/poly(2-oxazine) based diblock copolymer comprising thermosensitive/moderately hydrophobic poly(2-N-propyl-2-oxazine) (pPrOzi) hydrophilic poly(2-ethyl-2-oxazoline) (pEtOx). Hydrogels were only formed when block length exceeded certain (≈100 repeat units). The tube inversion rheological tests showed...
Belantamab mafodotin (belantamab) is a first-in-class anti-BCMA antibody-drug conjugate approved for the treatment of triple-class refractory multiple myeloma. It provides unique therapeutic option patients ineligible CAR-T and bispecific antibody therapy, and/or progressing on anti-CD38 where bispecifics might be kept in reserve. Wider use drug can challenged by its distinct ocular side effect profile, including corneal microcysts keratopathy. While dose reduction has been most effective...
Eudragit E 100 and polycaprolactone (PCL) floating microspheres for enhanced gastric retention drug release were successfully prepared by oil in water solvent evaporation method. Metronidazole benzoate, an anti-protozoal drug, was used as a model drug. Polyvinyl alcohol emulsifier. The observed % recovery, degree of hydration, uptake, loading, buoyancy release. physico-chemical properties the studied calculating encapsulation efficiency kinetics. Drug characteristics simulated fluid...
Abstract Adrenocortical carcinoma (ACC) is a rare tumor and prognosis overall poor but heterogeneous. Mitotane (MT) has been used for treatment of ACC decades, either alone or in combination with cytotoxic chemotherapy. Even at doses up to 6 g per day, more than half the patients do not achieve targeted plasma concentration (14–20 mg L −1 ) even after many months due low water solubility, bioavailability, unfavorable pharmacokinetic profile. Here novel MT nanoformulation very high...
A novel 3D printable hybrid hydrogel is developed and characterized in detail this study. After chemical curing of the 3D-printed constructs, resulting shows excellent mechanical strength with a tensile strain at break exceeding 550%.
The main objective of this study is to formulate a library difficult solubilize drugs with four slightly different poly(2-oxazoline)s (POx) and poly(2-oxazine)s (POzi) based amphiphilic triblock copolymers elucidate whether the drug-polymer compatibility, as estimated by solubility parameters (SPs) might be used tool guide formulation development. theoretical experimental SPs homo-/triblock 21 hydrophobic were calculated two group contribution methods (i.e. Hoftyzer Van-Krevelen Yamamoto...
Abstract Alginates are the most commonly used bioink in biofabrication, but their rheological profiles make it very challenging to perform real 3D printing. In this study, an advanced hybrid hydrogel ink was developed, a mixture of thermogelling diblock copolymer, alginate and clay i.e. Laponite XLG. The reversible shear thinning properties copolymer system improves handling printability significantly. Various three-dimensional constructs, including suspended filaments, were printed...
Considering the largely chiral nature of biological systems, there is interest in drug delivery systems. Here, we investigate for first time polymer micelles based on poly(2-oxazoline) (POx) ABA-type triblock copolymers with and racemic hydrophobic blocks formulation achiral drugs. Specifically, poly(2-ethyl-4-ethyl-2-oxazoline) (pEtEtOx) poly(2-propyl-4-methyl-2-oxazoline) (pPrMeOx) were used as block B poly(2-methyl-2-oxazoline) (pMeOx) hydrophilic A. Using these copolymers,...
The present work aimed to design and synthesize pH-sensitive cross-linked Ge/SA hydrogels using different ratios of each polymer, investigate the effect polymer on dynamic, equilibrium swelling, in vitro release pattern cetirizine hydrochloride, which was selected as a model drug.These gelatin sodium alginate were prepared at room temperature through free radical polymerization glutaraldehyde crosslinker. These polymeric composites used systems envisage various important characterizations....
Polymeric micelles are typically characterized as core-shell structures. The hydrophobic inner core is considered depot for molecules such drugs or catalysts and the corona forming block acts protective, stabilizing solubilizing interface between external aqueous milieu. Tremendous efforts have been made to tune increase drug loading stability of micelles, while role hydrophilic blocks regarding rarely studied in detail. To do so, we investigated a small library structurally similar A-B-A...
As one kind of smart material, thermogelling polymers find applications in biofabrication, drug delivery and regenerative medicine. Here, we reported on a novel thermosensitive hydrogel which can be 3D printed using extrusion based printing. Gel strength was found around 3kPa storage modulus with pronounced shear thinning rapid recovery after stress. Addition clay nanoparticles (Laponite XLG) improved the rheological profile further. Human adipose derived stem cells were added to matrix,...
Polymeric micelles are typically characterized as core-shell structures. The hydrophobic inner core is considered depot for molecules such drugs or catalysts and the corona forming block acts protective, stabilizing solubilizing interface between external aqueous milieu. Tremendous efforts have been made to tune increase drug loading stability of micelles, while role hydrophilic blocks regarding rarely studied in detail. To do so, we investigated a small library structurally similar A-B-A...
Adrenocortical carcinoma (ACC) is a rare tumor and prognosis overall poor but heterogeneous. Mitotane (MT) has been used for treatment of ACC decades, either alone or in combination with cytotoxic chemotherapy. Even at doses up to 6 g per day, more than half the patients do not achieve targeted plasma concentration (14-20 mg/L) even after many months which caused by low water solubility unfavorable pharmacokinetic properties such as bioavailability high volume distribution MT. The clinical...
<p></p><p>Despite decades of research, our understanding the molecular interactions between drugs and polymers in drug loaded polymer micelles does not extend much beyond concepts such as “like-dissolves-like“ or hydrophilic/hydrophobic. However, polymer-drug compatibility strongly affects formulation properties therefore translation a into clinics. Specific hydrogen-bonding, π-π stacking coordination can be utilized to increase drug-loading. This is commonly based on...
BT44 is a novel, second generation glial cell line-derived neurotropic factor (GDNF) mimetic, with improved biological activity and lead compound for the treatment of neurodegenerative disorders. Like many other small molecules, it suffers from intrinsic poor aqueous solubility, posing significant hurdles at various levels its preclinical development clinical translation. Herein, we report poly(2-oxazoline)s (POx) based micellar nanoformulation ultra-high drug loading capacity 47 wt.%. The...
In this study, an advanced hybrid ink was developed, based on a thermogelling block copolymer, alginate and clay. The reversible shear thinning properties polymer acts at the same time as fugitive material macromolecular level facilitates cell-laden extrusion bioprinting. <br>