A5114677132- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- interferon and immune responses
- Vector-borne infectious diseases
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Vector-Borne Animal Diseases
- RNA regulation and disease
- Cerebrovascular and Carotid Artery Diseases
- Protease and Inhibitor Mechanisms
- Plant Virus Research Studies
- Lipoproteins and Cardiovascular Health
- RNA modifications and cancer
- Microbial infections and disease research
- Viral Infectious Diseases and Gene Expression in Insects
- Virology and Viral Diseases
- RNA Research and Splicing
Nanjing Agricultural University
2013-2025
Yangzhou University
2020-2023
Temple College
2023
Temple University
2023
National Animal Husbandry Service
2022
Wenzhou Medical University
2021
ABSTRACT Porcine epidemic diarrhea virus (PEDV), a highly pathogenic enteric coronavirus, has caused significant economic losses worldwide in recent years. The PEDV spike (S) protein been reported to undergo extensive N-glycosylation, suggesting that glycosylation plays crucial role replication. In this study, we demonstrated the N-glycosylation pathway promotes replication by facilitating of S protein. First, observed pharmacological inhibition host using specific inhibitors significantly...
Peroxiredoxin 1 (PRDX1) is a cellular antioxidant enzyme that crucial for diverse fundamental biological processes, such as autophagy, inflammation, and carcinogenesis. However, molecular mechanisms underpinning its roles are not well understood. Here, we report PRDX1 positively regulates interferon (IFN) induction pseudorabies virus (PRV) targets to evade IFN induction. PRV UL13 encodes serine/threonine kinase important infection, although function remains obscure. We identified...
Abstract Long non-coding RNAs (lncRNAs) are a new arm of gene regulatory mechanism as discovered by sequencing techniques and follow-up functional studies. The lncRNAs regulation pseudorabies virus (PRV) infection has rarely been reported so far. Using RNA analysis, 225 with significant altered expressions in 3D4/21 cells infected PRV (ZJ01) were identified. Five upregulated PRV-infected verified different strains qRT-PCR. By down- up-regulation lnc641, the accelerating effect lnc641 on...
Long noncoding RNAs (lncRNAs) have increasingly been recognized as being integral to cellular processes, including the antiviral immune response. Porcine reproductive and respiratory syndrome virus (PRRSV) is costly global swine industry. To identify PRRSV-related lncRNAs, we performed RNA deep sequencing compared profiles of lncRNAs in PRRSV-infected uninfected Marc-145 cells. We identified a novel lncRNA called MAHAT (maintaining cell morphology-associated highly conserved transcript;...
LncRNAs are essential for regulating skeletal muscle. However, the expression profile and function of lncRNAs in goat muscle remains unclear. Here, an average ~14.58 Gb high-quality reads were obtained from longissimus dorsi tissues 1-month-old (n = 3) 9-month-old Wu'an black goats using RNA sequencing. Of a total 3441 lncRNAs, 1281 lincRNAs, 805 antisense 1355 sense_overlapping lncRNAs. These shared some properties with goats, such as fewer exons, shorter transcript, open reading frames...