A5074282313- Congenital gastrointestinal and neural anomalies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intestinal Malrotation and Obstruction Disorders
- Gastrointestinal motility and disorders
- Connective tissue disorders research
- Telemedicine and Telehealth Implementation
- Global Cancer Incidence and Screening
- COVID-19 and healthcare impacts
- Music Therapy and Health
- Mobile Health and mHealth Applications
- Immune Response and Inflammation
- Dermatological and Skeletal Disorders
- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Patient-Provider Communication in Healthcare
- Immune responses and vaccinations
- Viral gastroenteritis research and epidemiology
- Cancer Risks and Factors
- Family and Patient Care in Intensive Care Units
- Cancer Cells and Metastasis
- Balance, Gait, and Falls Prevention
- Omental and Epiploic Conditions
- Clinical practice guidelines implementation
- Immune cells in cancer
- Congenital Anomalies and Fetal Surgery
Texas Children's Hospital
2024
University of Michigan
2024
Michigan Medicine
2024
Beth Israel Deaconess Medical Center
2019-2022
Harvard University
2021-2022
Oregon Health & Science University
2021
Children's Hospital of Los Angeles
2019-2021
Doernbecher Children's Hospital
2020
Carilion Clinic
2015
Virginia Tech
2014-2015
Prior to the COVID-19 pandemic there were many barriers telemedicine primary care for adults ≥65 years including insurance coverage restrictions and having lower digital access literacy. With pandemic, broadened older utilized creating an opportunity learn from their experiences inform future policy.Between April 2020 June 2021, we conducted a cross-sectional multimethod study of English-speaking, cognitively-intact, ≥65, who had phone-only and/or video visit with physician within one large...
Innate monocytes and macrophages can be dynamically programmed into distinct states depending upon the strength of external stimuli. programming may bear significant relevance to pathogenesis resolution human inflammatory diseases. However, systems analyses with regard dynamic innate leukocytes are lacking. In this study, we focused on responses promonocytic THP-1 cells lipopolysaccharide (LPS). We observed that varying dosages LPS differentially modulate expression selected pro- anti-...
To learn how to improve telemedicine for adults >65, we asked primary care clinicians ("PCPs") affiliated with one large Boston-area health system their views on using (which included phone-only or video visits) >65 during the COVID-19 pandemic. In open-ended questions, PCPs describe any challenges useful experiences and suggestions improving as part of a larger web-based survey conducted between September 2020 February 2021. Overall, 163/383 (42%) responded survey. Of these, 114 (70%)...
Purpose Chronic obstructive pulmonary disease (COPD) is associated with multiple psychosocial and behavioral factors. Prior research suggests that mind-body interventions may support the development maintenance of healthy behaviors improve health-related quality-of-life in such patients. We sought to qualitatively explore cognitive, psychosocial, changes patients COPD who participated two different compared an education control. Methods analyzed semi-structured qualitative exit interviews...
Models for enteric neuropathies, in which intestinal nerves are absent or injured, required to evaluate possible cell therapies. However, existing options, including transgenic mice, variable and fragile. Here immunocompromised mice were implanted with human pluripotent stem cell–derived tissue-engineered small intestine 10 weeks prior a second survival surgery nervous system precursor cells, saline controls, injected into the organoid–derived analyzed 4 later. Human implants as controls...
The Gail, Breast Cancer Surveillance Consortium (BCSC), and Tyrer-Cuzick breast cancer risk prediction models are recommended for use in primary care. Calculating is particularly important women their 40s when deciding on mammography, with some guidelines recommending screening those 5-year similar to age 50 (≥1.1%). Yet, little known about estimate agreement among these women.
Despite current rehabilitation programs, long-term engagement in physical activity remains a significant challenge for patients with chronic obstructive pulmonary disease (COPD) and heart failure (HF). Novel strategies to promote these populations are greatly needed. Emerging literature on the benefits of both mind-body interventions web-based provide rationale development Mindful Steps intervention increasing walking behavior.
The small intestine has a remarkable ability to enhance its absorptive and digestive surface area through the formation of villi, process known as villification. We sought learn whether developing mouse human tissue-engineered (TESI) followed developmental biology routes villification, such Sonic hedgehog (SHH)/Indian (IHH) bone morphogenetic protein 4 (BMP4)/forkhead box F1 (FOXF1) signaling identify targets development TESI. After generating TESI from prenatal postnatal stem cell sources,...
Mutations in the paired-like homeobox 2 b (PHOX2B) gene are associated with congenital central hypoventilation syndrome (CCHS), which is a rare condition both autonomic dysregulation and an enteric neuropathy may occur. The majority of patients CCHS have polyalanine repeat mutation (PARM) PHOX2B, but minority nonpolyalanine mutations (NPARMs), some been localized to exon 1. A PHOX2B-Y14X nonsense previously generated human pluripotent stem cell (hPSC) line results NH2-terminus truncated...