A5043408977- Congenital gastrointestinal and neural anomalies
- Intestinal Malrotation and Obstruction Disorders
- Gastrointestinal motility and disorders
- Mechanical Circulatory Support Devices
- Infant Nutrition and Health
- Congenital Diaphragmatic Hernia Studies
- Dietary Effects on Health
- Immune Cell Function and Interaction
- Clinical Nutrition and Gastroenterology
- Central Venous Catheters and Hemodialysis
- IL-33, ST2, and ILC Pathways
- Liver Disease Diagnosis and Treatment
- Zebrafish Biomedical Research Applications
- Vascular Procedures and Complications
- Cardiovascular Conditions and Treatments
- Soft tissue tumors and treatment
- Regulation of Appetite and Obesity
- Cardiac Structural Anomalies and Repair
- Neurogenesis and neuroplasticity mechanisms
- Cancer Cells and Metastasis
- Wireless Power Transfer Systems
- Gastrointestinal Tumor Research and Treatment
- Diversity and Career in Medicine
- Hernia repair and management
- Hedgehog Signaling Pathway Studies
Michigan Medicine
2023-2024
C. S. Mott Children's Hospital
2023-2024
University of Michigan
2023-2024
Children's Hospital of Los Angeles
2019-2022
Weatherford College
2021
Yahoo (United Kingdom)
2021
University of Southern California
2020
Georgetown University
2015-2016
MedStar Georgetown University Hospital
2016
Abstract Dynamic regulation of intestinal cell differentiation is crucial for both homeostasis and the response to injury or inflammation. Sprouty2, an intracellular signaling regulator, controls pathways including PI3K MAPKs that are implicated in dysregulated inflammatory bowel disease. Here, we ask whether Sprouty2 secretory colitis. We report colonic epithelial deletion leads expanded tuft goblet populations. loss induces PI3K/Akt signaling, leading GSK3β inhibition interleukin (IL)-33...
Objective: The aim of this study was to evaluate pre-resection risk factors for neurodevelopmental impairment (NDI) in infants with necrotizing enterocolitis (NEC) that might better inform the timing intestinal resection. Summary Background Data: Surgical NEC is associated a 57% NDI. Methods: A retrospective patients who underwent resection within 10 days diagnosis between 2010 and 2019 conducted 11 US children’s hospitals. primary outcome NDI at 16-26 months. Demographics, findings...
In a zebrafish model that replicates common clinical scenario, systemic effects of the administration broad-spectrum antibiotics in SBS identified two alternate states led to establishment fat accumulation liver or its absence. Broad-spectrum given with over 2 wk altered intestinal microbiome, decreased and hepatic inflammation, steatosis.
Introduction: Splenectomy is common after trauma or hematologic disease, and alters immune protection against pathogens, which may lead to fulminant infection with high mortality. Yet the spleen has demonstrable regenerative capacity cells might be recovered reimplanted at time of injury excision avoid these risks. Methods: Tissue-engineered (TESp) was generated from ActinGFP mice (mTESp) human donor (hTESp) through implantation organoid units (spleen OU), in NOD/SCID concurrent splenectomy,...
Introduction In children requiring venoarterial (VA) extracorporeal membrane oxygenation (ECMO) for long durations, conversion to venovenous (VV) support may be advantageous. The purpose of this study was evaluate the feasibility and safety from VA VV ECMO. Methods This is a retrospective review all who underwent ECMO at single institution, 2015 2022. Indications methods were examined as well adverse events including re-operation, ischemic complications, renal failure, mortality. Results Of...
Background In approaching surgical correction of Hirschsprung disease (HSCR), laparoscopic Swenson endorectal pull-through (Lap-S-ERPT) requires less transanal dissection and sphincter stretch. This may lead to more immediate postoperative obstructive symptoms. While antibiotics rectal irrigations are mainstays treatment, there is concern about instrumentation in the setting recent low anal anastomosis. The purpose this study was assess incidence safety early following Lap-S-ERPT. Methods a...
R-spondins, including R-spondin 1 (RSPO1), are a family of Wnt ligands that help to activate the canonical Wnt/β-catenin pathway, which is critical for intestinal epithelial cell proliferation and maintenance stem cells. This underpins expansion, or adaptation (IA), occurs following massive bowel resection short syndrome (SBS). The purpose this study was identify if recombinant human RSPO1 (rhRSPO1) could be serially administered SBS zebrafish enhance cellular IA. Adult male were assigned...
Abstract Dynamic regulation of intestinal cell differentiation is crucial for both homeostasis and the response to injury or inflammation. Sprouty2, an intracellular signaling regulator, controls pathways including PI3K MAPKs that are implicated in dysregulated inflammatory bowel disease. Here, we asked whether Sprouty2 secretory colitis. We report colonic epithelial deletion led expanded goblet tuft populations. loss induced PI3K/Akt signaling, leading GSK3β inhibition interleukin (IL)-33...
Background Gastrostomy tube (G-tube) placement is commonly performed on pediatric patients but has high rates of emergency department (ED) utilization. We hypothesized that a nurse-practitioner-driven G-tube clinic would reduce ED visits and complications improve provider patient satisfaction. Methods After institutional review board approval, retrospective chart was conducted for all < 18 years old undergoing between January 2014 June 2018. Data collected included demographics,...
Mutations in the paired-like homeobox 2 b (PHOX2B) gene are associated with congenital central hypoventilation syndrome (CCHS), which is a rare condition both autonomic dysregulation and an enteric neuropathy may occur. The majority of patients CCHS have polyalanine repeat mutation (PARM) PHOX2B, but minority nonpolyalanine mutations (NPARMs), some been localized to exon 1. A PHOX2B-Y14X nonsense previously generated human pluripotent stem cell (hPSC) line results NH2-terminus truncated...
Extracorporeal membrane oxygenation cannulation strategies vary between adults and children. Femoral approach is common in extremity morbidity well-documented. Aside from limb ischemia, complications children are theorized have yet to be studied. This study aims comprehensively evaluate implications of pediatric femoral cannulation.
Soft tissue sarcoma (STS) represents an exceedingly rare group of cancers comprising 50 histologic subtypes, with approximately 15,000 new diagnoses per year (CA Cancer J Clin 2009;59(4):225-249). Each type exhibits a unique biologic behavior and, as such, prognosis and optimal treatment modalities vary amongst each subtype. This makes the entity whole complex to diagnose treat. The natural history disease options are often tied intimately particular histology's genomic underpinnings (Adv...