A5048006563- Nanoparticle-Based Drug Delivery
- Helicobacter pylori-related gastroenterology studies
- Cancer Cells and Metastasis
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Digestive system and related health
- Fibroblast Growth Factor Research
- IL-33, ST2, and ILC Pathways
- Computational Drug Discovery Methods
- Endodontics and Root Canal Treatments
- Migraine and Headache Studies
- Dental Radiography and Imaging
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Dental materials and restorations
- Sympathectomy and Hyperhidrosis Treatments
- Therapeutic Uses of Natural Elements
- Nanoplatforms for cancer theranostics
- Trigeminal Neuralgia and Treatments
- Barrier Structure and Function Studies
- Caveolin-1 and cellular processes
- Neonatal Respiratory Health Research
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Nigella sativa pharmacological applications
Imam Abdulrahman Bin Faisal University
2015-2024
Alsalam University College
2021
Stem Cell Institute
2018
Children's Hospital of Los Angeles
2014-2017
University of Southern California
2015-2016
Prince Mohammad bin Fahd University
2015
The ERBB4 receptor tyrosine kinase promotes colonocyte survival. Herein, we tested whether ERBB4’s antiapoptotic signaling transformation and colorectal tumorigenesis. alterations in a Cancer Genome Atlas cancer (CRC) data set stratified survival, combined Moffitt Center Vanderbilt Medical CRC expression set, message levels were increased at all tumor stages. Similarly, western blot immunohistochemistry on additional tissue banks showed elevated protein tumors. was highly expressed...
Abstract Efficient clearance of pro-inflammatory macrophages from tissues after resolution a challenge is critical to prevent prolonged inflammation. Defects in can contribute conditions such as inflammatory bowel disease, and thus may be therapeutically targetable. However, the signaling pathways that induce termination are incompletely defined. We tested whether ErbB4 receptor tyrosine kinase, previously not known have role macrophage biology, involved this process. In vitro , activation...
A chemo-drug such as cisplatin is effective for cancer treatment but remains non-specific, susceptible to drug resistance, and induces several side effects on organ systems. Zeolitic imidazolate framework-8, a type of MOF, has gained attention, including delivery method targeted therapeutics. In this study, ZIF-8/Silica nanocomposite was synthesized using one-pot hydrothermal technique the Stober technique. We studied effect phyto-synthesized GPt CPt efficacy therapy. The texture,...
Poly (methyl methacrylate) (PMMA) is basically biocompatible polyester with high resistance to chemical hydrolysis, and drug permeability the most important characteristics of PMMA that it does not produce any toxicity. There much information about action on colon cancer cells. In present study, we have synthesized nanoparticles. The distribution pattern particles was analysed by Zeta sizer size calculated using quasi elastic light scattering (QELS). surface structure morphology were...
Abstract Dynamic regulation of intestinal cell differentiation is crucial for both homeostasis and the response to injury or inflammation. Sprouty2, an intracellular signaling regulator, controls pathways including PI3K MAPKs that are implicated in dysregulated inflammatory bowel disease. Here, we ask whether Sprouty2 secretory colitis. We report colonic epithelial deletion leads expanded tuft goblet populations. loss induces PI3K/Akt signaling, leading GSK3β inhibition interleukin (IL)-33...
Intestinal epithelial cell renewal relies on the right balance of migration, proliferation, differentiation, and apoptosis. cells consist absorptive secretory lineage. The latter is comprised goblet, Paneth, enteroendocrine cells. Fibroblast growth factor 10 (FGF10) plays a central role in survival, differentiation several organs. expression pattern FGF10 its receptors both human mouse intestine their small have yet to be investigated. First, we analyzed FGF10, FGFR1, FGFR2, ileum throughout...
Currently, breast cancer treatment mostly revolves around radiation therapy and surgical interventions, but often these treatments do not provide satisfactory relief to the patients cause unmanageable side-effects. Nanomaterials show promising results in treating cells have many advantages such as high biocompatibility, bioavailability effective therapeutic capabilities. Interestingly, fluorescent magnetic nanoparticles been used biological diagnostic applications, there is no report of use...
Nanoparticles have many advantages such as high biocompatibility, bioavailability and effective therapeutic capabilities. The aim of the present study is to examine whether fluorescent magnetic submicronic polymer nanoparticles (FMSP-nanoparticles) any impact on human colorectal cancer cells. In study, we tested FMSP-nanoparticles with an average size 100-200 nm carcinoma cells (HCT-116) check their cytotoxic anti-cancer effects were observed after 6 h, 24 h 48 intervals. response...
Both nanoparticles and cloves (Syzygium aromaticum) possess anticancer properties, but they do not elicit a significant response on cancer cells when treated alone. In the present study, we have tested fluorescent magnetic submicronic polymer (FMSP-nanoparticles) in combination with crude clove extracts human breast (MCF-7) to examine whether approach enhance cell death. The MCF-7 were different concentrations (1.25 μ g/mL, 12.5 50 75 100 g/mL) of FMSP-nanoparticles alone g/mL extracts....
Background: Obesity is a global pandemic that associated with high morbidity and mortality.Natural herbs are commonly used for weight reduction appetite suppression.Therefore, we aim to investigate the role mechanism of Nigella sativa (NS) ginger on regulation.Methods: This experimental study was performed at Imam Abdulrahman Bin Faisal University.Twenty-five female rats were distributed into 5 groups: NS (oral 1000mg/kg), Ginger (500 mg/kg), NS-ginger (both interventions), positive control...
Background B-cell lymphoma/leukaemia 11A (BCL11A) is a C2H2-type zinc-finger transcription factor protein that critical modulator of haemoglobin switching and suppresses the production foetal haemoglobin. Variation in BCL11A gene ameliorates severity sickle cell disease (SCD) β-thalassemia (β-thal). The located on chromosome 2p16.1 encodes an 835-amino acid protein. Method Using state-of-the-art silico tools, this study examined most pathogenic non-synonymous single nucleotide polymorphisms...
In nanotherapeutics, gaining insight about the drug interaction with pore architecture and surface functional groups of nanocarriers is crucial to aid in development targeted delivery. Manganese ferrite impregnated graphene oxide (MnFe2O4/GO) a two-dimensional sheet spherical silica three-dimensional interconnected porous structure (MnFe2O4/silica) were evaluated for cisplatin release cytotoxic effects. Characterization studies revealed presence Mn2+ species variable spinel cubic phase...
The combination of magnetic nanoparticles with a porous silica is composite that has attracted significant attention for potential multifunctional theranostic applications. In this study, 30 wt % CuFe 2 O 4 was impregnated into matrix monodispersed spherical hydrophilic (HYPS) through simple dry impregnation technique. chemotherapy drug cisplatin loaded electrostatic equilibrium adsorption over 24 h in normal saline solution. presence cubic spinel on HYPS confirmed powder X-ray diffraction...
Novel antifungal drugs are urgently needed to treat candidiasis caused by the emerging fungal multidrug-resistant pathogen Candida auris. In this study, most cost-effective drug repurposing technology was adopted identify an appropriate option among 1615 clinically approved with anti-C. auris activity. High-throughput virtual screening of 1,3-beta-glucanosyltransferase inhibitors conducted, followed analysis stability complexes and 1,3-beta-glucanosyltransferase–dutasteride metabolite...