A5085573815- Telemedicine and Telehealth Implementation
- COVID-19 and healthcare impacts
- Mobile Health and mHealth Applications
- Healthcare Systems and Technology
- Cancer, Hypoxia, and Metabolism
- Health Literacy and Information Accessibility
- Wireless Body Area Networks
- Health disparities and outcomes
- Ophthalmology and Eye Disorders
- Ubiquitin and proteasome pathways
- Frailty in Older Adults
- Emergency and Acute Care Studies
- Chronic Myeloid Leukemia Treatments
- Brain Metastases and Treatment
- Patient Satisfaction in Healthcare
- ECG Monitoring and Analysis
- Food Security and Health in Diverse Populations
- Healthcare Operations and Scheduling Optimization
- Global Health Care Issues
- Cancer-related cognitive impairment studies
- Histone Deacetylase Inhibitors Research
- Hospital Admissions and Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Bone health and treatments
- Cannabis and Cannabinoid Research
Michigan Medicine
2024
Beth Israel Deaconess Medical Center
2019-2024
Harvard University
2022-2023
Massachusetts General Hospital
2022-2023
University of Michigan
2023
Mount Sinai Beth Israel
2020
Mayo Clinic in Arizona
2013-2016
Toronto Public Health
2015
Henry Ford Hospital
2014
Mayo Clinic
2014
The tumor microenvironment presents physical, immunologic, and metabolic barriers to durable immunotherapy responses. We have recently described roles for both T cell insufficiency as well hypoxia inhibitory mechanisms that prevent activity in murine tumors, but whether intratumoral or response varies between patients a function of distinct profiles cells remains unclear. Here, we show derangement can vary widely degree type patient-derived lines ex vivo analysis patient samples, such some...
Uveal melanoma (UM) is the most common intraocular malignancy in adults. In contrast to cutaneous (CM), there no standard therapy, and efficacy safety of dual checkpoint blockade with nivolumab ipilimumab not well defined.
Prior to the COVID-19 pandemic there were many barriers telemedicine primary care for adults ≥65 years including insurance coverage restrictions and having lower digital access literacy. With pandemic, broadened older utilized creating an opportunity learn from their experiences inform future policy.Between April 2020 June 2021, we conducted a cross-sectional multimethod study of English-speaking, cognitively-intact, ≥65, who had phone-only and/or video visit with physician within one large...
To learn how to improve telemedicine for adults >65, we asked primary care clinicians ("PCPs") affiliated with one large Boston-area health system their views on using (which included phone-only or video visits) >65 during the COVID-19 pandemic. In open-ended questions, PCPs describe any challenges useful experiences and suggestions improving as part of a larger web-based survey conducted between September 2020 February 2021. Overall, 163/383 (42%) responded survey. Of these, 114 (70%)...
Objectives Understanding trends of marijuana use in the USA throughout a period particularly high adoption marijuana-legalisation, and understanding demographics most at risk use, is important evolving healthcare policy intervention. This study analyses demographic-specific changes prevalence between 2005 2018. Design, setting participants A 14-year retrospective cross-sectional analysis National Health Nutrition Examination Survey database, publicly available biennially collected national...
AS RESEARCHERS CONTINUE TO ILLUMINATE THE COMPLEXITIES OF NEUROLOGIC DISORDERS AND THEIR MANAGEMENT, CLINICIAN FACES AN EQUALLY INTENSIFYING BURDEN: how to communicate these advances effectively patients. Health literacy (HL) refers a person's ability find, comprehend, and use basic information resources in order make appropriate decisions related his or her health. We describe the first study of low HL prevalence using validated measure cohort adult neurology outpatients without dementia....
Background Remote monitoring (RM) of cardiac implantable electronic devices has been shown to improve cardiovascular morbidity and mortality. To date, no studies have investigated disparities in use delivery RM. This study was performed investigate if racial socioeconomic are present device Methods Results a retrospective observational cohort at single tertiary care center the United States. Patients who received newly implanted or upgrade between January 2017 December 2020 were included....
Meningioma is one of the most common primary neoplasms in central nervous system, but no specific molecularly targeted therapy has been approved for clinical treatment aggressive meningiomas. There hence an urgent demand to decrypt biological and molecular landscape malignant meningioma. Here, through in-silica prescreening 10-year follow-up studies 445 meningioma patients, we uncovered that CBX7 expression progressively decreases with malignancy grade neoplasia stage meningioma, a high...
A healthier diet is associated with lower chronic disease burden, but the impact of neighbourhood food environments on disability and death in older adults not known. In Cardiovascular Health Study, a cohort study aged 65+, we calculated years until (years life (YOL)), without activities daily living (ADL) difficulty able life; YoAL) percent ADL (compression disability). Linear regression quantified associations establishments within 5 km baseline home address (as z-score) each outcome,...
144 Background: Denosumab is a monoclonal antibody that neutralizes RANKL preventing osteoclast activation. It has been shown to be superior zoledronic acid in skeletal-related events breast cancer with bone metastases. Hypocalcemia reported as common side effect. The aim evaluate the risk factors associated denosumab induce hypocalcemia. Methods: Retrospective study which charts were reviewed. Baseline characteristics: age, gender, race, type of cancer, calcium, phosphate, vitamin D, PTH,...
e17687 Background: Patients with cancer associated VTE have a 4-fold higher risk of mortality compared to patients no VTE. If anticoagulants are discontinued, 30% recurrence rates at one year . In controlled clinical trials, low molecular weight heparin (LMWH) reduced vitamin K antagonists (VKA) by nearly 50%. in “real world” setting unknown Methods: Using retrospective study design, consecutive Mayo Clinic pancreatic, breast, and lung treated solely weight-based LMWH were assessed from Jan...
<h3>Background</h3> Resident continuity-clinic (RCC) is a crucial component of ambulatory training in primary care.The no-show rate (NSR) large academic center with 60 residents averaged 27% year (AY) 2018, despite an automated phone/text reminder system 3 days prior to appointment, resulting fragmented care, reduced access and decreased learning opportunities for residents. <h3>Objectives</h3> To determine whether telephone outreach targeting patients predicted be at high-risk can reduce...
Introduction: Remote monitoring (RM) of cardiac implantable electronic devices (CIEDs) has been shown to improve cardiovascular morbidity and mortality. To date, no studies have investigated disparities in utilization delivery RM. This study was performed investigate if racial socioeconomic are present CIED Methods: Retrospective observational cohort at a single tertiary care center the United States. Patients who received newly implanted or device upgrade between 01/17 12/20 were included....