A5073081371- Tryptophan and brain disorders
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Biochemical Acid Research Studies
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Chemical Reactions and Isotopes
- Renal cell carcinoma treatment
- Stress Responses and Cortisol
- Microbial Metabolic Engineering and Bioproduction
- Adenosine and Purinergic Signaling
- Diet, Metabolism, and Disease
- Prostate Cancer Treatment and Research
- Colorectal Cancer Treatments and Studies
- Glutathione Transferases and Polymorphisms
- Biochemical and Molecular Research
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Proteomics Techniques and Applications
- Cancer Risks and Factors
- Bioinformatics and Genomic Networks
- Vitamin D Research Studies
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
Pirogov Russian National Research Medical University
2020-2025
Peoples' Friendship University of Russia
2022-2024
Russian New University
2022
Ministry of Health of the Russian Federation
2022
Donetsk National Medical University
2013-2017
Obesity, type 2 diabetes mellitus (T2DM), and related metabolic disorders occupy the leading positions on lists of diseases worldwide. It is not surprising that efforts many scientific groups clinicians are aimed at finding effective therapeutic strategies to treat these diseases. In recent decades, involvement intestinal microbiota in pathogenesis metabolic, immune, other humans has become increasingly obvious. this regard, attempts made modulate composition functional activity as a primary...
Aim . To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, serotonin pathways tryptophan metabolism a cohort patients with obesity. Materials methods. Using high-performance liquid chromatography mass spectrometric detection, several serum metabolites, such as kynurenic acid, anthranilic xanthurenic quinolinic 5-hydroxyindole-3-acetate, tryptamine, serotonin, indole-3-lactate, indole-3-acetate, indole-3- butyrate,...
Large-scale epidemiological and clinical studies have demonstrated the efficacy of metformin in oncology practice. However, mechanisms implementation anti-tumor effect this drug there is still need understanding. In study we investigated on activity adenosine deaminase respectively adenosinergic immunosuppression tumors their microenvironment. The material was taken during surgery breast cacer patients receiveing metformin, also which did not take drug. substrate (adenosine) products...
Tumors interact with various populations of nonmalignant cells, such as endothelial, stromal, and immune to create a favorable tumor microenvironment (TME) for invasion metastasis cancer cells. A key mechanism maintaining the pro-oncogenic properties TME is formation an immunosuppressive environment that allows avoid response. strictly supported mainly by activity engaged cells secrete inflammatory cytokines factors inhibit function cytotoxic T lymphocytes. On other hand, tumor-associated...
The role of lactic acid (lactate) in cell metabolism has been significantly revised recent dec-ades. Initially, was attributed to the a toxic end product metabolism, which accumulation and extracellular space leads acidosis, muscle pain other adverse effects. However, it now become obvious that lactate is not only universal fuel molecule main substrate for gluconeogenesis, but also one most ancient metabolites with signaling function, wide range regulatory activity. Warburg effect described...
Today, it is believed that the human body and intestinal microbiota exist in a metabolic coupling based on principle of mutualism. The main function microbiotic population hyperproduction short-chain fatty acids, which perform an energy for both microorganisms cells, regulate quo- rum participate response immune cells macroorganism through specific signaling mechanisms. Also, characteristic link «superorganism» pathways tryptophan and, respectively, indoles, kynurenines serotonin. Indole...
We found that changes in the concentrations of tryptophan metabolites blood serum and intestinal contents are one mechanisms for formation metabolic coupling system "macroorganism-intestinal microbiota", which undergoes significant development obesity. Although kynurenine remained basically unchanged obese children we an increase some its metabolites: anthranilic, kynurenic xanthurenic acids. It is noteworthy analysis fecal matter children, revealed a 2-fold level while concentration pathway...
The signaling role of tryptophan and its catabolites is well known. However, their effects on the potential microbiota metabolic activity still poorly understood. study was aimed to assess concordance between changes in predicted gut microbiome enzyme-encoding gene abundance catabolites. involved 109 healthy volunteers 114 obese patients. Quantification feces performed by HPLC. Bacterial DNA extracted from fecal samples, 16S rRNA V3-V4 region sequenced. Primary processing sequencing data...
Obshcheizvestna signal'naya rol' triptofana i ego katabolitov. Odnako do sih por ne izucheno ih vliyanie na potencial'nuyu metabolicheskuyu aktivnost' mikrobioty. Cel'yu issledovaniya bylo provesti analiz soglasovannosti izmenenij prognosticheskoj predstavlennosti genov fermentov mikrobioma kishechnika katabolitov triptofana. V issledovanii prinyali uchastie 109 zdorovyh dobrovol'cev 114 bol'nyh s ozhireniem. Kolichestvennyj obmena v kale provodili metodom VEZHKH. Iz obrazcov fekalij...
In modern scientific literature, close attention is paid to the biological role of tryptophan catabolites both in normal conditions and various pathologies. There are more reports that metabolism play a signaling human body intestinal microbial community. Receptors pathways body, so-called molecules (TrySM), their cellular targets, physiological metabolic effects being actively studied. It has now been established almost all molecules. Many them realize through aryl hydrocarbon receptors...