A5053523433- SARS-CoV-2 and COVID-19 Research
- Evolution and Genetic Dynamics
- COVID-19 epidemiological studies
- Chromosomal and Genetic Variations
- Viral Infections and Outbreaks Research
- Genomics and Phylogenetic Studies
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- interferon and immune responses
- Animal Virus Infections Studies
- Vehicle Dynamics and Control Systems
- Electric and Hybrid Vehicle Technologies
- Viral Infections and Immunology Research
- COVID-19 Pandemic Impacts
- Mosquito-borne diseases and control
- Neonatal Respiratory Health Research
- Zoonotic diseases and public health
- Tracheal and airway disorders
- Real-time simulation and control systems
- SARS-CoV-2 detection and testing
- Congenital Diaphragmatic Hernia Studies
- Viral gastroenteritis research and epidemiology
- Genetic diversity and population structure
- CRISPR and Genetic Engineering
- Respiratory viral infections research
National Taiwan University
2020-2025
Academia Sinica
2021-2025
Biodiversity Research Center, Academia Sinica
2020-2025
National Taiwan University Hospital
2022
Abstract Background SARS-CoV-2 began spreading in December 2019 and has since become a pandemic that impacted many aspects of human society. Several issues concerning the origin, time introduction to humans, evolutionary patterns, underlying force driving outbreak remain unclear. Method Genetic variation 137 genomes related coronaviruses as 2/23/2020 was analyzed. Result After correcting for mutational bias, excess low frequency mutations on both synonymous nonsynonymous sites revealed which...
ABSTRACT Chromosome rearrangements significantly influence speciation, but the role of chromosome fission is paradoxical due to its link with unbalanced segregation. The kinetochore reproduction theory suggests that fissions from duplication should allow normal segregation, though empirical support remains scarce. In Opsariichthyini tribe (Asian river chub), number vary 2N=48 in most genera 76-78 Opsariichthys 15 events. harbors over species, substantially surpassing typical three four...
ABSTRACT The percomorph fish clade Gobioidei is a suborder that comprises over 2200 species distributed in nearly all aquatic habitats. To understand the genetics underlying their diversification, we sequenced and annotated genome of loach goby, Rhyacichthys aspro , an early‐diverging group, compared it with nine additional species. Within Gobioidei, goby possesses smallest at 594 Mb, rise diversity from to more recently diverged lineages mirrored by enlarged genomes higher presence...
Abstract Analyses of the genomic diversity SARS-CoV-2 found that some sites across genome appear to have mutated independently multiple times with frequency significantly higher than four-fold sites, which can be either due mutational bias, i.e., elevated mutation rate in genome, or selection variants antagonistic pleiotropy, a condition where mutations increase components fitness at cost others. To examine how different forces shaped evolution 2020–2021, we analyzed large set sequences (~ 2...
Abstract The spread of SARS-CoV-2 since December 2019 has become a pandemic and impacted many aspects human society. Here, we analyzed genetic variation its related coronavirus found the evidence intergenomic recombination. After correction for mutational bias, analysis 137 genomes as 2/23/2020 revealed excess low frequency mutations on both synonymous nonsynonymous sites which is consistent with recent origin virus. In contrast to adaptive evolution previously reported SARS-CoV in brief...
The purpose of this study is to compare the clinical characteristics and surgical outcomes thoracotomy video-assisted thoracoscopic surgery (VATS) in children with congenital lung malformations (CLMs) a tertiary referring center report our modified biportal VATS setting.This single-center retrospective chart review including who underwent resection for CLMs between January 2007 December 2020. Patient were compared open thoracoscopy, as well conventional VATS. Biportal setting included an...
not-yet-known unknown To be successful a virus must maintain high between-host transmissibility while also effectively adapting within hosts. The impact of these potentially conflicting demands on viral genetic diversity and adaptation remains largely unexplored. These modes can induce uncorrelated selection, bring to frequency mutations that enhance certain fitness aspects at others' expense, contribute the maintenance variation. vast wealth SARS-CoV-2 data gathered from across hosts offers...
<title>Abstract</title> To be successful a virus must maintain high between-host transmissibility while also effectively adapting within hosts. The impact of these potentially conflicting demands on viral genetic diversity and adaptation remains largely unexplored. These modes can induce uncorrelated selection, bring to frequency mutations that enhance certain fitness aspects at others' expense, contribute the maintenance variation. vast wealth SARS-CoV-2 data gathered from across hosts...
ABSTRACT Since the first report of SARS-CoV-2 in December 2019, Taiwan has gone through three local outbreaks. Unlike two outbreaks, spatial and temporal origin third outbreak (April 20 to November 5, 2021) is still unclear. We assembled analyzed a data set more than 6,000 genomes, including 300 from 5812 related sequences downloaded GISAID as 2021/12/08. found that was caused by single virus lineage belonging Alpha (B.1.1.7) strain. This lineage, T-III (the Taiwan), carries distinct genetic...
Abstract One of the unique features SARS-CoV-2 is its apparent neutral evolution during early pandemic (before February 2020). This contrasts with preceding SARS-CoV epidemics, where viruses evolved adaptively. may exhibit a or adaptive feature which deviates from other coronaviruses. Alternatively, virus have been cryptically circulating in humans for sufficient time to acquired changes before onset current pandemic. To test scenarios above, we analyzed sequences minks (Neovision vision)...
In a world where environment protection and energy conservation are growing concerns, the development of hybrid electric vehicles (HEV) has taken on an accelerated pace. We put our attention research parallel heavy motorcycle. this paper, electrical control system is mainly focused new system; among them include car's using instant battery charger, Li-ion management system. sliding mode motor system, we design modified output feedback controller. The controller only variable proposed to...
Background: Since the first report of SARS-CoV-2 in December 2019, Taiwan has gone through three local outbreaks. Unlike two outbreaks, spatial and temporal origin third outbreak (April 20 to November 5, 2021) is still unclear. Methods: We assembled a data set more than 6,000 genomes, including 300 from 5812 related sequences downloaded GISAID as 2021/12/08. then estimated phylogeny set, characterized clusters with distinctive mutations.Findings: Using we found that was caused by single...
ABSTRACT One of the unique features SARS-CoV-2 is that it mainly evolved neutrally or under purifying selection during early pandemic. This contrasts with preceding epidemics closely related SARS-CoV and MERS-CoV, both which adaptively. It possible exhibits a adaptive feature deviates from other coronaviruses. Alternatively, virus may have been cryptically circulating in humans for sufficient time to acquired changes efficient transmission before onset current In order test above scenarios,...