A5041646812- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- RNA Interference and Gene Delivery
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Animal Disease Management and Epidemiology
- Cell Adhesion Molecules Research
- T-cell and Retrovirus Studies
- Immune cells in cancer
- Reproductive System and Pregnancy
Institut Curie
2020-2024
Inserm
2020-2024
Université Paris Sciences et Lettres
2020-2023
Université Paris Cité
2020-2023
Centre National de la Recherche Scientifique
2022
Immunité et Cancer
2020
Université des Lettres et des Sciences Humaines de Bamako
2020
University of Buenos Aires
2017-2019
Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2019
Institute of Astronomy and Space Physics
2019
Significance Our work uncovers mechanisms by which tumor cells impact tumor-associated macrophages in human triple-negative breast cancer. Via extracellular vesicles (EVs), these tumors promote with proinflammatory features, correlated better clinical outcome. results suggest exploration of EVs as tools, alone, or combination other therapies, to a favorable environment for the generation anti-tumor immune responses.
The tetraspanins CD9, CD81 and CD63 are major components of extracellular vesicles (EVs). Yet, their impact on EV composition remains under-investigated. In the MCF7 breast cancer cell line was as expected predominantly intracellular. contrast CD9 strongly colocalized at plasma membrane, albeit with different ratios sites, which may explain a higher enrichment in EVs. Absence these had little protein analysed by quantitative mass spectrometry. We also effect concomitant knock-out because two...
Abstract SARS‐CoV‐2 entry is mediated by binding of the spike protein (S) to surface receptor ACE2 and subsequent priming host TMPRSS2 allowing membrane fusion. Here, we produced extracellular vesicles (EVs) exposing demonstrate that ACE2‐EVs are efficient decoys for S protein‐containing lentivirus. Reduction infectivity positively correlates with level ACE2, much more than soluble further enhanced inclusion TMPRSS2.
Extracellular vesicles (EVs), including endosome-derived nanovesicles (exosomes) are involved in cell-cell communication. Through transfer of their molecular contents, extracellular can alter the function recipient cells. Due to these characteristics, EVs have shown potential as a new alternative for cancer immunotherapy. Tumor exosomes isolated from malignant ascites activate dendritic cells, thereby priming immune system recognize and kill However, suppressive role on tumor response has...
Abstract Cells secrete extracellular vesicles (EVs) and non‐vesicular (nano)particles (NVEPs or ENPs) that may play a role in intercellular communication. Tumor‐derived EVs have been proposed to induce immune priming of antigen presenting cells be immuno‐suppressive agents. We suspect such disparate functions are due variable compositions EV subtypes ENPs. aimed characterize the array secreted ENPs murine tumor cell lines. Unexpectedly, we identified virus‐like particles (VLPs) from...
ABSTRACT SARS-CoV-2 entry is mediated by binding of the spike protein (S) to surface receptor ACE2 and subsequent priming TMPRRS2 allowing membrane fusion. Here, we produced extracellular vesicles (EVs) exposing demonstrate that ACE2-EVs are efficient decoys for S protein-containing lentivirus. Reduction infectivity positively correlates with level ACE2, 500 1500 times more than soluble further enhanced inclusion TMPRSS2.
Foot and mouth disease (FMD) is a highly contagious infection caused by FMD-virus (FMDV) that affects livestock worldwide with significant economic impact. The main strategy for the control vaccination FMDV chemically inactivated binary ethylenimine (FMDVi). In vaccination, B cell response plays major role providing neutralizing/protective antibodies in animal models natural hosts. Extracellular vesicles (EVs) small EVs (sEVs) such as exosomes are important cellular communication. secreted...
ABSTRACT Cells secrete membrane-enclosed extracellular vesicles (EVs) and non-vesicular nanoparticles (ENPs) that may play a role in intercellular communication. Tumor-derived EVs have been proposed either to induce immune priming of antigen presenting cells, or, be immuno-suppressive agents promoting tumor escape. We suspect such disparate functions are due variable composition EV subtypes ENPs the analyzed preparations. aimed exhaustively characterize array secreted murine cell lines....