A5034672730- Aortic aneurysm repair treatments
- Genomics, phytochemicals, and oxidative stress
- Nanoparticle-Based Drug Delivery
- Curcumin's Biomedical Applications
- Electrolyte and hormonal disorders
- Metabolism and Genetic Disorders
- Renal function and acid-base balance
- Seaweed-derived Bioactive Compounds
- Potassium and Related Disorders
- Reproductive System and Pregnancy
- Synthesis and Characterization of Heterocyclic Compounds
- Linguistic research and analysis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Vitamin C and Antioxidants Research
- Advanced Glycation End Products research
- Aortic Disease and Treatment Approaches
- Sodium Intake and Health
- Genetics, Aging, and Longevity in Model Organisms
- Poisoning and overdose treatments
- Mitochondrial Function and Pathology
- Exercise and Physiological Responses
- Vitamin K Research Studies
- Adipose Tissue and Metabolism
- Pharmacology and Obesity Treatment
- Cardiac Ischemia and Reperfusion
Jagiellonian University
2019-2024
University of Agriculture in Krakow
2018-2021
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
1998
University Hospital Bonn
1980
Goethe University Frankfurt
1976
Curcumin is a natural polyphenol with anti-inflammatory, chemopreventive and anticancer activity. However, its high hydrophobicity poor bioavailability limit medical application. The development of nanocarriers for curcumin delivery an attractive approach to overcome low fast metabolism in the liver. We synthesized blood compatible alginate-curcumin conjugate, AA-Cur, which formed colloidally stable micelles approximately 200 nm and, as previously shown, exerted strong cytotoxicity against...
Surgical intervention is currently the only option for an abdominal aortic aneurysm (AAA), preventing its rupture and sudden death of a patient. Therefore, it crucial to determine pathogenic mechanisms this disease development effective pharmacological therapies. Oxidative stress said be one pivotal factors in pathogenesis AAAs. Thus, we aimed evaluate significance nuclear factor erythroid 2-related 2 (Nrf2) transcriptional activity AAA verify if simvastatin, administered as pre-...
The breach of proteostasis, leading to the accumulation protein aggregates, is a hallmark ageing and age-associated disorders, up now well-established in neurodegeneration. Few studies have addressed issue dysfunctional cell response deposition also for cardiovascular system. However, molecular basis proteostasis decline vascular cells, as well its relation ageing, are not understood. Recent indicated associations Nrf2 transcription factor, critical modulator cellular stress-response, with...
Abdominal aortic aneurysm (AAA) bears a high risk of rupture and sudden death the patient. The pathogenic mechanisms AAA remain elusive, surgical intervention represents only treatment option. Heme oxygenase-1 (HO-1), heme degrading enzyme, is induced in AAA, both mice humans. HO-1 was reported to mitigate development an angiotensin II (AngII)-induced model hyperlipidemic ApoE-/- mice. Since role hyperlipidaemia pathogenesis remains controversial, we aimed evaluate significance progression...
Abstract Background Adult muscle-resident myogenic stem cells, satellite cells (SCs), that play non-redundant role in muscle regeneration, are intrinsically impaired Duchenne muscular dystrophy (DMD). Previously we revealed dystrophic SCs express low level of anti-inflammatory and anti-oxidative heme oxygenase-1 (HO-1, HMOX1 ). Here assess whether targeted induction affect SC function alleviates hallmark symptoms DMD . Methods We generated double-transgenic mouse model (mdx; Pax7Ind ) allows...
1. The effect of long-term treatment with prindolol on blood pressure, total body potassium (Kt), exchangeable sodium (Nae) and plasma renin activity was investigated in twelve patients essential hypertension. 2. Systolic diastolic pressures were significantly reduced from 164/112 to 127/90 mmHg under basal conditions. 3. Before Na. hypertension higher than normotensive individuals. After an average 16 weeks Nae decreased, despite increase weight 2 kg the patients. 4. In contrast decrease...
Up to date, there is no information on the influence of 2,2,2-tribromoethanol (TBE; Avertin), a commonly used anaesthetic, mice with impaired antioxidant capacity. We aimed analyse effect single dose Avertin anaesthesia duration time, inflammatory response, oxidative stress and collagen deposition in large intestine Nrf2 transcriptional knockout (tNrf2−/−). The studies were performed six-month-old female Nrf2+/+ tNrf2−/− randomly assigned (250 mg/kg b.w. i.p. injection) or vehicle group....
The serum and total body potassium was investigated in 25 patients with non-congestive cardaic failure before during saluretic treatment. Treatment triamterene (100 mg/d; n = 10) over a period of 3 weeks led to an increase (from 4.1 +/- 0.65 4.7 0.51 mmol/l) (by 110 mmol). After treatment chlortalidon for 7 days 6) concentration decreased from 4.38 "/- 0.37 3.30 0.46 mmol/l (approximately 25%). by 240 mmol 10%). Continuation the combination (50 mg/d) (150 correction extra- intracellular loss...
Abstract Background The elastomechanical properties of nanocarriers have recently been discussed as important for the efficient delivery various therapeutics. Some data indicate that optimal nanocarriers’ elasticity can modulate in vivo nanocarrier stability, interaction with phagocytes, and uptake by target cells. Here, we presented a study to extensively analyze behavior LIP-SS liposomes were modified forming silicone network within lipid bilayers improve their properties. We verified...
The aim of our study was to evaluate the premise (Jenzano 1992) that estrogen influences female mixed saliva kallikrein level (MSK).We estimated MSK from woman between ages 17 and 39 with (n = 20) without (20) contraceptive medication (at least an one year treatment) postmenopausal women 47 65 22) hormonal substitution. Kallikrein by means cleavage chromogenic tripeptide Val-Leu-Arg-p-nitranilide (SIGMA) absorbance measuring p-nitraniline at 405 nm.A Wilcoxon test conducted for statistical...
Sucher, R; Gehwolf, P; Oberhuber, Maglione, M; Werner, E; Obrist, Schneeberger, S; Öllinger, Margreiter, Brandacher, G Author Information
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, A-1200 Vienna, Austria Medical Chemistry, Innsbruck, Austria.