A5004465631- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
- Chemokine receptors and signaling
- Cellular transport and secretion
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Neuroscience and Neuropharmacology Research
- Tissue Engineering and Regenerative Medicine
- T-cell and B-cell Immunology
- Eicosanoids and Hypertension Pharmacology
- Advanced Glycation End Products research
- Fire Detection and Safety Systems
- IoT-based Smart Home Systems
- Intravenous Infusion Technology and Safety
- Inflammasome and immune disorders
- Ion channel regulation and function
- Coronary Interventions and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Heme Oxygenase-1 and Carbon Monoxide
VA Palo Alto Health Care System
2015-2018
Stanford University
2018
San Jose State University
2015
Abstract Plasma membrane rupture (PMR) in dying cells undergoing pyroptosis or apoptosis requires the cell-surface protein NINJ1 1 . PMR releases pro-inflammatory cytoplasmic molecules, collectively called damage-associated molecular patterns (DAMPs), that activate immune cells. Therefore, inhibiting and may limit inflammation is associated with excessive cell death. Here we describe an anti-NINJ1 monoclonal antibody specifically targets mouse blocks oligomerization of NINJ1, preventing PMR....
The C-C motif chemokine receptor 8 (CCR8) is a class A G-protein coupled that has emerged as promising therapeutic target in cancer. Targeting CCR8 with an antibody appeared to be attractive approach, but the molecular basis for chemokine-mediated activation and antibody-mediated inhibition of are not fully elucidated. Here, we obtain antagonist against human determine structures complex either or endogenous agonist ligand CCL1. Our studies reveal characteristic features allowing recognition...
Background: We developed an aligned bi-layered vascular graft derived from human induced pluripotent stem cells (iPSCs) that recapitulates the cellular composition, orientation, and anti-inflammatory function of blood vessels. Materials & methods: The luminal layer consisted longitudinal-aligned nanofibrillar collagen containing primary endothelial (ECs) or iPSC-derived ECs (iPSC-ECs). outer contained circumferentially oriented with smooth muscle (SMCs) SMCs(iPSC-SMCs). Results: On...
NALCN (sodium leak channel, nonselective) is vital for regulating electrical activity in neurons and other excitable cells, mutations the channel or its auxiliary proteins lead to severe neurodevelopmental disorders. Here, we show that neuronal SNARE (soluble N -ethylmaleimide–sensitive factor attachment protein receptors) complex syntaxin SNAP25 (synaptosome-associated 25), which enable synaptic transmission nervous system, inhibit of both heterologous systems primary neurons. The existence...
Background CEP (ω-[2-carboxyethyl]pyrrole) protein adducts are the end products of lipid oxidation associated with inflammation and have been implicated in induction angiogenesis pathological conditions such as tissue ischemia. We synthesized small molecules derived from evaluated angiogenic effect analog 03 setting peripheral arterial disease. Methods Results The was assessed by vitro analysis primary human microvascular endothelial cell proliferation tubelike formation Matrigel (Corning)....
Abstract The sodium leak channel NALCN is vital for the regulation of electrical activity in neurons and other excitable cells, mutations or its auxiliary proteins lead to severe neurodevelopmental disorders. Here we show that neuronal SNARE complex syntaxin SNAP25, which enable synaptic transmission nervous system, inhibit both heterologous systems primary neurons. existence this interaction suggests neurotransmitter release machinery can regulate signalling directly, therefore modulate...
According to the current pandemic situation body hygiene maintenance is top most priority. An automatic hand sanitizer dispenser automated and alcohol based important criteria that it touch-less machine, which will be used in hospitals, schools, work places much more. Concentration of 70% can kill corona-virus hand, scientifically proven. Here an ultrasonic sensor detects human whenever placed near machine also check distance between dispenser. Contactless temperature here a person result...