A5087093191- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Protein Degradation and Inhibitors
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Gout, Hyperuricemia, Uric Acid
- Protein Structure and Dynamics
- Spondyloarthritis Studies and Treatments
- Cancer Research and Treatments
- Blood disorders and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Heat shock proteins research
- Amyotrophic Lateral Sclerosis Research
- Endoplasmic Reticulum Stress and Disease
- NF-κB Signaling Pathways
Chungnam National University Hospital
2023
Korea Research Institute of Bioscience and Biotechnology
2014-2018
Chungnam National University
2014-2015
Université Laval
2013
Human DNAJC12 is a J domain-containing protein whose regulation, subcellular localization, and function are currently unknown. We show here that the abundance of in human LNCaP prostate cancer cells upregulated by stress-inducing drug A23187 stressregulated transcription factor AIbZIP/CREB3L4. The gene encodes two isoforms, only one which (isoform a) expressed these cells. Immunofluorescence studies showed recombinant diffusely distributed cytoplasm. To identify substrates DNAJC12, we used...
// Jin Sun Choi 1 , 8 Byoung Chul Park Seung Wook Chi Kwang-Hee Bae 2 Sunhong Kim 3 10 Sayeon Cho 5 Woo-Chan Son 6 7 Pyung Keun Myung Jeong-Hoon 4 9 Sung Goo Medical Proteomics Research Center, Korea Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic Cell Function Regulation Targeted Medicine Gene College Pharmacy, Chung-Ang University, Seoul, Asan for Life Sciences and Department Pathology, University Ulsan Medicine, Chungnam National Functional Genomics, Biomolecular...
Abstract Spondyloarthritis (SpA) is a chronic inflammatory disease that results in bone ankylosis. The tissue renin-angiotensin system (RAS) an emerging pathway potentially implicated SpA-associated changes. aim of the present study was to determine mechanisms underlying this relationship. Sakaguchi (SKG) mice injected with curdlan (SKGc), animal models for SpA, were treated RAS modulators, angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors (ACEis). Disease...
Ubiquitination is a post translational modification which mostly links with proteasome dependent protein degradation. This process has been known to play pivotal roles in the number of biological events including apoptosis, cell signaling, transcription and translation. Although ubiquitination studied extensively, mechanism polyubiquitination by multi E3 ubiquitin ligase, SCF complex remains elusive. In present study, we identified UbcH5a as novel stimulating factor for poly-ubiquitination...