A5090267127- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Computational Drug Discovery Methods
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- PI3K/AKT/mTOR signaling in cancer
- Machine Learning in Bioinformatics
- NF-κB Signaling Pathways
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- ATP Synthase and ATPases Research
Korea Research Institute of Bioscience and Biotechnology
2017-2024
Korea Advanced Institute of Science and Technology
2017
Molecular glue degraders, such as lenalidomide and pomalidomide, bind to cereblon (CRBN) E3 ligase subsequently recruit neosubstrate proteins, Ikaros (IKZF1) Aiolos (IKZF3), for the ubiquitination-proteasomal degradation process. In this study, we explored structure-activity relationship analysis novel GSPT1 degraders utilizing a benzotriazinone scaffold previously discovered CRBN binder. particular, focused on position of ureido group scaffold, substituent effect phenylureido group, methyl...
Sung Ah Kim, Seung-Hyun Jo, Jin Hwa Cho, Min Yeong Yu, Ho-Chul Shin, Jung-Ae Goo Park, Byoung Chul Sunhong and Jeong-Hoon Kim. Mol. Cells 2020;43:935-44. https://doi.org/10.14348/molcells.2020.0122
Abstract Von Hippel–Lindau (VHL) is a tumor suppressor that functions as the substrate recognition subunit of CRL2VHL E3 complex. While substrates VHL have been identified, its suppressive role remains to be fully understood. For further determination substrates, we analyzed physical interactome and identified histone H3K9 methyltransferase SETBD1 novel target. SETDB1 undergoes oxygen-dependent hydroxylation by prolyl hydroxylase domain proteins complex recognizes hydroxylated for...
The CRISPR-Cas9 system is a widely used gene-editing tool, offering unprecedented opportunities for treating various diseases. Controlling Cas9/dCas9 activity at specific location and time to avoid undesirable effects very important. Here, we report conditionally active that regulates target gene expression upon sensing cellular environmental change. We conjugated the oxygen-sensing transcription activation domain (TAD) of hypoxia-inducing factor (HIF-1α) with protein. Cas9-TAD conjugate...