A5030757123- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- PI3K/AKT/mTOR signaling in cancer
- Redox biology and oxidative stress
- Natural product bioactivities and synthesis
- Protein Kinase Regulation and GTPase Signaling
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds and Antitumor Agents
- Fungal and yeast genetics research
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Enzyme Structure and Function
- Mitochondrial Function and Pathology
- Advanced Proteomics Techniques and Applications
- Cancer-related gene regulation
- ATP Synthase and ATPases Research
- Immune Response and Inflammation
- Cancer Mechanisms and Therapy
- RNA and protein synthesis mechanisms
Chung-Ang University
2015-2024
Korea University
2016
Korea Research Institute of Bioscience and Biotechnology
2001-2013
Harvard University
2001-2002
Brandeis University
1996-1998
Various herbal extracts containing luteolin-7-O-glucuronide (L7Gn) have been traditionally used to treat inflammatory diseases. However, systemic studies aimed at elucidating the anti-inflammatory and anti-oxidative mechanisms of L7Gn in macrophages are insufficient. Herein, effects their underlying action were explored. inhibited nitric oxide (NO) production lipopolysaccharide (LPS)-stimulated RAW 264.7 by transcriptional regulation inducible NO synthase (iNOS) a dose-dependent manner. The...
Oxidative stress and chronic inflammation are closely linked to various diseases. However, previous studies have demonstrated that plant extracts could prevent alleviate these adverse outcomes. Piper betle Linn. (Piper L.) is a cosmopolitan belongs the Piperaceae family, whose leaves edible possess several health benefits. This study sought characterize anti-inflammatory antioxidant effects of methanol extract L. stems (MPBLLS). MPBLLS was found dose-dependent radical scavenging effect, as...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-reactivity correlations for reactions of substituted phenolate anions with acetate and formate estersDimitrios Stefanidis, Sayeon Cho, Sirano Dhe-Paganon, William P. JencksCite this: J. Am. Chem. Soc. 1993, 115, 5, 1650–1656Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ja00058a006https://doi.org/10.1021/ja00058a006research-articleACS...
Purine catabolic pathway in Bacillus subtilis is consisted of more than 14 genes. Among these genes, pucL and pucM are required for uricase activity. While PucL known to encode the itself, function PucM still unclear although this protein also indispensable uric acid decomposition. Here, we provide evidence that PucM, a transthyretin‐related protein, functions facilitate hydrolysis 5‐hydroxyisourate, end product reaction. Based on results, propose proteins present diverse organisms not...
Although dual-specificity phosphatase 5 (DUSP5), which inactivates extracellular signal-regulated kinase (ERK), suppresses tumors in several types of cancer, its functional roles remain largely unknown. Here, we show that DUSP5 is induced during lipopolysaccharide (LPS)-mediated inflammation and inhibits nuclear factor-κB (NF-κB) activity. mRNA protein expression increased transiently LPS-stimulated RAW 264.7 cells then returned to basal levels. overexpression suppressed the production...
The doublesex gene of Drosophila melanogaster encodes the alternatively spliced, sex-specific transcription factors DSX M and F .These regulate male-and female-specific many genes.For example, yolk protein 1 is regulated by repression in males activation females.In this study we used vitro interaction assays vivo yeast two-hybrid method to identify examine oligomerization domains proteins.A 66-amino-acid segment common both proteins (amino acids 39 104) contains a sequence-specific DNA...
The hypoxia‐inducible factor‐1α (HIF‐1α) is an important transcription factor for cellular responses to oxygen tension. It rapidly degraded under normoxic conditions by the ubiquitin‐dependent proteasome pathway. Here we report a critical role of 20S subunit PSMA7 in HIF‐1α regulation. was found interact specifically with two subdomains HIF‐1α. inhibited transactivation function both and hypoxia‐mimicking conditions. In addition, show that PSMA7‐mediated regulation activity associated
Hepatitis B virus X protein (HBx) of the hepatitis is strongly implicated in angiogenesis and metastasis during hepatocarcinogenesis. Previously, we reported that HBx enhances activity hypoxia-inducible factor-1alpha (HIF-1alpha), a potent transactivator induces angiogenic factors. Here, delineate structural region potentiates HIF-1alpha. The carboxy-terminus increased stability HIF-1alpha protein, probably through inhibiting interaction with von Hippel-Lindau protein. Further, enhanced...
The activation of caspases is a critical event for the execution phase programmed cell death. Caspases are highly specific in their ability to activate or inhibit many crucial proteins via site-specific cleavage. To date, more than 60 have been shown be substrates one mammalian cells, and list still growing. In this study, identify human caspase-3 substrates, we digested lysates obtained from caspase-3-deficient MCF-7 line with purified analyzed eliminated decreased spots by 2-DE. Proteins...
Caspase-3 (CASP3) plays a key role in apoptosis. In this study, HAX-1 was identified as new substrate of CASP3 during cleaved by etoposide-(ETO) induced apoptosis, and event inhibited CASP3-specific inhibitor. The cleavage site HAX-1, at Asp127, located using V-terminal amino acid sequencing vitro products recombinant HAX-1. Overexpression ETO-induced apoptotic cell death. It also activity. Together, these results suggest that CASP3, inhibits the process inhibiting
Mitogen-activated protein kinases (MAPKs) are involved in a variety of intracellular events such as gene expression, cell proliferation, and programmed death. MAPKs activated by dual phosphorylation on threonine tyrosine residues through sequential activation kinases. Recent studies have shown that the MAPK signal transductions might be organized into signaling complexes scaffold proteins. These proteins essential regulators function assembling relevant molecular components mammalian cells....
Abstract Pancreatic cancer remains one of the most deadly cancers with a grave prognosis. Despite continuous efforts to improve remedial values, limited progress has been made. We have reported that dual specificity phosphatase 28 (DUSP28) critical role chemo-resistance and migration in pancreatic cancers. However, its mechanism unclear. Here, we further clarify function DUSP28 Analysis using public microarray database vitro assay indicated platelet derived growth factor A (PDGF-A)...