A5037562191- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
- CAR-T cell therapy research
- Natural product bioactivities and synthesis
- Virus-based gene therapy research
- NF-κB Signaling Pathways
- PI3K/AKT/mTOR signaling in cancer
- Protein Kinase Regulation and GTPase Signaling
- CRISPR and Genetic Engineering
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects of Medicinal Plants
- Tannin, Tannase and Anticancer Activities
- Neuroendocrine Tumor Research Advances
- Ubiquitin and proteasome pathways
- Reproductive Biology and Fertility
- Bioactive Natural Diterpenoids Research
- Macrophage Migration Inhibitory Factor
- Biomedical and Engineering Education
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Protease and Inhibitor Mechanisms
- Cardiac electrophysiology and arrhythmias
- Bioactive Compounds and Antitumor Agents
- Lung Cancer Research Studies
Center for Drug Evaluation and Research
2023
United States Food and Drug Administration
2023
Korea Institute of Science and Technology
2019-2020
Chung-Ang University
2013-2017
Although dual-specificity phosphatase 5 (DUSP5), which inactivates extracellular signal-regulated kinase (ERK), suppresses tumors in several types of cancer, its functional roles remain largely unknown. Here, we show that DUSP5 is induced during lipopolysaccharide (LPS)-mediated inflammation and inhibits nuclear factor-κB (NF-κB) activity. mRNA protein expression increased transiently LPS-stimulated RAW 264.7 cells then returned to basal levels. overexpression suppressed the production...
Genetically engineered cells via CRISPR/Cas9 system can serve as powerful sources for cancer immunotherapeutic applications. Furthermore, multiple genetic alterations are necessary to overcome tumor-induced immune-suppressive mechanisms. However, one of the major obstacles is technical difficulty with efficient gene manipulation suspension due low transfection efficacy. Herein, we established a carrier-free multiplexed editing platform in simplified method, which enhance function cytotoxic...
Mitogen-activated protein kinases (MAPKs) are involved in a variety of intracellular events such as gene expression, cell proliferation, and programmed death. MAPKs activated by dual phosphorylation on threonine tyrosine residues through sequential activation kinases. Recent studies have shown that the MAPK signal transductions might be organized into signaling complexes scaffold proteins. These proteins essential regulators function assembling relevant molecular components mammalian cells....
Atezolizumab is an immune checkpoint inhibitor (ICI) targeting PD-L1 for treatment of solid malignancies. Immune checkpoints control the tolerance, and adverse events such as hepatotoxicity induced by ICIs are often considered immune-related event (irAE). However, also highly expressed in normal tissues, e.g., hepatocytes. It still not clear whether, on hepatocytes, atezolizumab may cause damage to liver cells contributing hepatotoxicity. Here, we reveal a novel mechanism which induces human...
Small-cell lung cancer (SCLC) is the most aggressive form of and leading cause global cancer-related mortality. Despite earlier identification membrane-proximal cleavage cell adhesion molecule 1 (CADM1) in cancers, role membrane-bound fragment CAMD1 (MF-CADM1) yet to be clearly identified. In this study, we first isolated MF-CADM1-specific fully human single-chain variable fragments (scFvs) from synthetic scFv antibody library using phage display technology. Following selected conversion...
Myrmecodia platytyrea Becc., a member of the Rubiaceae family, is found throughout Southeast Asia and has been traditionally used to treat cancer. However, there limited pharmacological information on this plant. We investigated anticancer effects methanol extract Becc. leaves (MMPL) determined molecular mechanisms underlying MMPL metastasis in human hepatocellular carcinoma (HCC) cells. dose-dependently inhibited cell migration invasion SK‑Hep1 Huh7 In addition, strongly suppressed...
Numerous Euphorbiaceae plants have been used for the treatment of diseases, including liver asthma and rheumatism. The present study evaluated effect methanol extracts from Euphorbia cooperi (MEC), a member plant family, on production inflammatory cytokines interleukin (IL)‑6 tumor necrosis factor (TNF)‑α, nitric oxide (NO) as well activation mitogen‑activated protein kinase nuclear (NF)‑κB signaling. Non‑cytotoxic concentrations MEC significantly reduced NO IL‑6, but not TNF‑α, in...
Protein phosphorylation is an essential mechanism for human health and disease, which regulated by the coordinated activities of kinases phosphatases. occurs predominantly on serine, threonine, tyrosine residues eukaryotic proteins plays critical roles in regulation physiological processes including gene expression, proliferation, differentiation, cell cycles arrest, apoptosis. Mitogen-activated protein (MAP) are mediators signal transduction pathways regulating embryogenesis, death response...
E-mail: sycho@cau.ac.krReceived July 6, 2012, Accepted 23, 2012Key Words : DUSP13B, NSC 663284, PTP inhibitorDual-specificity phosphatases (DUSPs) are group ofenzymes that belong to the superfamily of protein-tyrosinephosphatases and catalyze dephosphorylation proteinsat both phosphorylated tyrosine serine/threonineresidues.
There-fore, the finding and developing of specific inhibitorsthat target protein phosphatase or kinases are essential partsfor treatment cancer chronic inflammatory disease.There over 100 tyrosine (PTP)superfamily genes in human genome, compared to 90 proteintyrosine kinase (PTK) genes.
The Src homology 2 (SH2) domain-containing phosphatase (SHP-2) is a nonreceptor protein tyrosine (PTP) involved in extracellular-regulated kinase (ERK) activation. Recent studies have shown that gain-of-function mutations SHP-2 are associated with several diseases, including LEOPARD syndrome, Noonan and juvenile myelomonocytic leukemia. In this study, we identified the novel inhibitor 3-(1-benzimidazolylmethyl)-6-p-tolyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (MLS-001). activity was...
Based on the amino acidsequences of catalytic domains, over 100 protein tyro-sine phosphatases can be classified into four separatefamilies: (i) class I cysteine-based PTPs containing classicalPTPs and dual-specificity (DSPs), (ii)class II PTPs: tyrosine-specific low mole-cular weight phosphatases, (iii) III PTPscontaining CDC25 homology (CH2) domain, (iv) Eyesabsent (EyA) proteins as members aspartic acid-basedPTPs.