A5060821296- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Neonatal and fetal brain pathology
- Tracheal and airway disorders
- Congenital Anomalies and Fetal Surgery
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Infant Nutrition and Health
- Preterm Birth and Chorioamnionitis
- Pleural and Pulmonary Diseases
- Airway Management and Intubation Techniques
- Neonatal Health and Biochemistry
- Pediatric Hepatobiliary Diseases and Treatments
- Maternal and Neonatal Healthcare
- Pregnancy and preeclampsia studies
- Infant Development and Preterm Care
- Lymphatic Disorders and Treatments
- Prenatal Screening and Diagnostics
- Galectins and Cancer Biology
- Pharmaceutical studies and practices
- Cardiovascular Conditions and Treatments
- Sexual Differentiation and Disorders
- Respiratory viral infections research
- Blood groups and transfusion
Administração Regional de Saúde de Lisboa e Vale do Tejo
2025
Universidade do Porto
2025
Centro Hospitalar do Porto
2014-2024
Hospital de Santo António
2010-2024
Hospital de São João
2010-2018
CUF Porto Hospital
2010
Sociedad Española de Cuidados Intensivos Pediátricos
2003
Hospital Maria Pia
1998-2002
The perfusion index (PI) is a non-invasive method to assess peripheral perfusion, derived from and displayed by pulse oximeters. While oximetry demonstrates moderate sensitivity in detecting obstructive left heart lesions, including coarctation of the aorta (CoA), its limitations underscore need for improved screening techniques. This report presents cases two full-term neonates diagnosed with CoA, highlighting role PI early detection before clinical signs such as discrepancies blood...
Renal tubular dysgenesis (RTD) is a rare disorder characterized by impaired development of the renal tubules. It often fatal condition that should be considered in differential diagnosis neonatal kidney failure. RTD can classified as primary (linked to deleterious variants genes encoding renin-angiotensin system (RAS) proteins) or secondary an underlying cause. In this case report, we present late preterm female neonate born at 35 weeks elective cesarean section due oligohydramnios and fetal...
Persistent patency of the ductus arteriosus (PDA) has challenged neonatologists for more than 40 years. Controversies persist about management PDA in extremely preterm infants. is associated with morbidities, but no therapeutic strategy resulted an improved neonatal outcome. Acetaminophen appears to be a promising alternative possibly fewer adverse effects. The primary objective determine whether prophylactic pharmacological intervention acetaminophen may increase survival without severe...
Pleural effusions are rare in the neonate and may be associated to several clinical conditions. Only a few series of pleural fetus newborn described literature.This study was undertaken determine more accurately causes prognostic significance population high-risk neonates.A retrospective chart review 62 neonates admitted neonatal intensive care unit six medical centers north Portugal, between 1997 2004, that presented diagnosis effusion.33M/29F newborns; preterms 47 (76%); GA 33 (25-40) wk;...
To evaluate the association between histological chorioamnionitis and brain damage (intraventricular hemorrhage cystic periventricular leukomalacia) in preterm newborn.This was a retrospective study on neonates born at less than 34 weeks gestational age, their respective mothers, three tertiary medical centers north of Portugal, from January 2001 to December 2002.The included 452 newborns (235 male/217 female; birth weight 1440 (515-2620) grams; age 31 (23-33) weeks), 125 mothers whose...
Various cytokines have been associated to the occurrence of bronchopulmonary dysplasia (BPD) in preterm neonates.To establish an association between cord blood and BPD, so that they could be used, clinical practice, as early markers BPD.Preterms less than 30 weeks gestational age, were analysed by ELISA microassay for venous IL-1β, IL-6, IL-8, TNF-α IL-10, compared BPD non-BPD groups.One hundred fifty neonates completed study; 31 (21%) small age (SGA); 16 deceased before 28 days life; 36...
Introduction : Various cytokines have been associated to the occurrence of bronchopulmonary dysplasia (BPD) in preterm neonates. AIM To establish an association between cord blood and BPD, so that they could be used, clinical practice, as early markers BPD. Material methods Preterms less than 30 weeks gestational age, were analysed by ELISA microassay for venous IL-1 β , IL-6, IL-8, TNF- α IL-10, compared BPD non-BPD groups. Results One hundred fifty neonates completed study; 31 (21%) small...
A retrospective chart review of 18 nonvaccinated newborns and infants admitted to 6 intensive care units in the north Portugal between 2007 2012 revealed a high rate admissions along with significant rates severe pulmonary hypertension mortality. Hyperleukocytosis was significantly associated more clinical picture
Abstract Introduction: Pleural effusions are rare in the neonate and may be associated to several clinical conditions. Only a few series of pleural fetus newborn described literature. Aim: This study was undertaken determine more accurately causes prognostic significance population high‐risk neonates. Materials methods: A retrospective chart review 62 neonates admitted neonatal intensive care unit six medical centers north Portugal, between 1997 2004, that presented diagnosis effusion....
Congenital disorders of glycosylation (CDG) are a group hereditary diseases characterised by deficiency enzymes involved in proteins glycosylation. We describe the clinical case neonate with CDG type 1a, nowadays designated phosphomannomutase 2 (PMM2)-CDG. Physical examination showed an abnormal facies, axial hypotonia, fat distribution, inverted nipples, non-palpable testicles and arachnodactyly. Progressive multiple system organ involvement worsening hypertrophic cardiomyopathy occurred....
The pathogenesis of bronchopulmonary dysplasia (BPD) is clearly multifactorial. Specific pathogenic risk factors are prematurity, respiratory distress, oxygen supplementation, mechanical ventilation (MV), inflammation, patent ductus arteriosus (PDA), etc.To evaluate BPD prevalence and to identify for in five Portuguese Neonatal Intensive Care Units order develop better practices the management these newborns.256 very low birth weight infants with gestational age (GA) <30 weeks and/or...
Several studies assessed the influence of a low birth weight on bronchopulmonary dysplasia (BPD), but not all could find significant association. Our aim was to assess association between and BPD in preterm infants, prospectively recruited at 11 level III Portuguese neonatal centers.Obstetrical data mothers infants with gestational ages 24 30 weeks, born during 2015 2016 after surveilled pregnancy, were analyzed. Neonates considered small for age (SGA) when their birthweight below 10th...
Blueberry muffin syndrome (BMS) in neonates, characterized by widespread nodular lesions, presents diagnostic challenges due to its diverse etiologies. Hyperleukocytosis, with leukocyte counts exceeding 100,000/μL, is a rare phenomenon associated severe complications neonates. Congenital leukemia (CL), diagnosis within the first month of life, linked high mortality. This case report unique BMS hyperleukocytosis as initial presentation CL. A full-term male newborn, born after an uncomplicated...
Noonan syndrome is a relatively common and heterogeneous genetic disorder, associated with congenital heart defect in about 50% of the cases. If not severe, life expectancy normal. We report case preterm infant hypertrophic cardiomyopathy lethal outcome to acute respiratory distress caused by Adenovirus pneumonia. A novel mutation RAF1 gene was identified: c.782C>G (p.Pro261Arg) heterozygosity, described previously literature. Consequently, clinical course this its respective contribution...
There is little data on the association between Human Leucocyte Antigen (HLA) alleles and Bronchopulmonary Dysplasia (BPD) of preterm newborn. Our aim was to assess associations HLA BPD susceptibility. We studied 156 neonates (82 M/ 74 F) < 32 weeks gestational age, alive at 36 age. Detailed clinical were collected. typing performed by PCR-SSO. allele frequencies where determined direct counting for no-BPD groups. Comparison no groups using t-test, χ2 test or Fisher exact logistic regression...
Introduction: Sudden and unexpected postnatal collapse is a rare event with potentially dramatic consequences. Intervention approaches are limited, but hypothermia has been considered after collapse. The aim of this study was to analyse sudden cases that underwent therapeutic in the five Portuguese centres.Material Methods: In multicentre, retrospective descriptive study, clinical, ultrasonography, amplitude-integrated electroencephalography brain magnetic resonance findings newborns...
Introdução: O espectro clínico da malformação adenomatóide cística pulmonar congénita (MACPC) va-ria desde lesões assintomáticas e dificuldade respiratória no recém-nascido a hidrópsia fetal. Objectivos: Avaliação casuística de MACPC, real-çando história natural, tratamento evolução. Material métodos: Análise retrospectiva dos processos clínicos todos os recém-nascidos com o diagnóstico admitidos nas unidades cui-dados intensivos neonatais cinco centros terciários do Norte Portugal, entre...
Respiratory syncytial virus (RSV) lower respiratory tract infection is the most common viral in infants. Several authors have sought to determine which risk factors are best predictors for severe RSV disease. Our aim was evaluate if a specific chest radiographic pattern disease can predict severity. We conducted multicenter retrospective cohort study term and preterm neonates with confirmed infection, admitted neonatal intensive care units (NICU) from 2000 2010. To independently predicted...