In cross-sectional and retrospective cohort studies, we examined comparative associations between nonalcoholic fatty liver disease (NAFLD) metabolic dysfunction-associated (MAFLD) risk of having or developing coronary artery calcification (CAC). Participants who had health examinations 2010 2019 were analyzed. Liver ultrasonography computed tomography used to diagnose CAC. divided into a MAFLD no-MAFLD group then NAFLD no-NAFLD groups. further no (reference), NAFLD-only, MAFLD-only, both...

The regeneration of the mucosal interface human intestine is critical in host–gut microbiome crosstalk associated with gastrointestinal diseases. biopsy-derived intestinal organoids provide genetic information patients physiological cytodifferentiation. However, enclosed lumen and static culture condition substantially limit utility patient-derived for microbiome-associated disease modeling. Here, we report a patient-specific three-dimensional (3D) physiodynamic interface-on-a-chip (PMI...

Abstract Background The risk of heart failure (HF) in underweight diabetes mellitus (DM) patients has rarely been studied. We conducted a cohort study to investigate the association between (BMI < 18.5 kg/m 2 ) and BMI change over time HF with type DM. Methods utilized health screening data from National Health Insurance Service Korean Screening database 2009 2012, follow‐up until December 2018. Participants DM were categorized into four groups based on their at 4 years before inclusion...

Only a few studies have evaluated the relationship between physical activity (PA) and Homeostatic model assessment for insulin resistance (HOMA-IR). Therefore, we aimed to analyze association HOMA-IR PA. We included 280,194 Korean without diabetes who underwent health examinations. The short form of International Physical Activity Questionnaire was completed. PA level divided into sedentary, mild PA, health-enhancing (HEPA). levels were calculated. Confounding factors including waist...

Aim: We compared the association between baseline and average lipid parameters over time coronary artery calcification (CAC) risk.

Abstract The relationship between hyperhomocysteinemia (HHcy) and obesity with low skeletal muscle mass (LMM) has not been established. We aim to assess the association HHcy coexistence of LMM in asymptomatic adult population. conducted a population-based cross-sectional study among individuals who underwent measurements plasma homocysteine body composition analysis. was defined as > 15 umol/L, index ≥ 25 (kg/m 2 ), less than SD below sex-specific mean young adults. participants were...

SB12 is being developed as a proposed biosimilar to eculizumab reference product (RP), humanized monoclonal antibody (IgG2/4 kappa immunoglobulin) that binds the human C5 complement protein. Binding this protein inhibits complement-mediated intravascular hemolysis by blocking its cleavage into C5a and C5b. Eculizumab RP indicated for treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH) reduce hemolysis, atypical hemolytic uremic syndrome (aHUS) inhibit thrombotic...

IMR is useful for assessing the microvascular dysfunction after primary percutaneous coronary intervention (PCI). It remains unknown whether index of microcirculatory resistance (IMR) reflects functional outcome in patients with anterior myocardial infarction (AMI) or without obstruction (MO).This study was performed to evaluate clinical value injury and predicting recovery AMI undergoing PCI. We enrolled 34 first AMI. After successful PCI, mean distal artery pressure (P(a)), wedge (P(cw)),...

Primary squamous cell carcinoma (SCC) of the liver is very rare, and few cases have been reported in Korea. SCC known to be associated with hepatic cysts intrahepatic stones. A 71-year-old male was admitted our hospital, a abdominal computed tomography scan revealed 10 × 6 cm mass liver. Analysis biopsy sample suggested SCC, so team performed thorough workup find primary lesion, which hepatoma as pure multiple distant metastases. The patient treated one cycle radiotherapy, transferred...

We investigated the relationship between high carcinoembryonic antigen (CEA) levels and low skeletal muscle mass (LMM) in asymptomatic adults a population-based study. A total of 202,602 (mean age 41.7 years) without malignancy, stroke, cardiovascular disease, or chronic lung/liver disease were included. CEA level was defined as ≥5 ng/mL. Skeletal index (SMI) calculated based on appendicular (kg)/height (m)2. Participants classified into three groups SMI: “normal”, “mild LMM”, “severe LMM.”...

Previous studies have reported that abnormal glucose metabolism is associated with poor cancer outcomes. Glycated hemoglobin A1c (HbA1c) an important indicator of metabolism. This study aimed to investigate the relationship between nondiabetic HbA1c levels and cancer-related mortality. was a retrospective cohort Koreans who attended annual or biennial health checkup program. The group categorized based on quintile level (Q1, 3.0-5.1%; Q2, 5.2-5.3%; Q3, 5.4%; Q4, 5.5-5.6%, Q5, 5.7-6.4%)....

Background: Increased coronary artery calcification (CAC) has been reported in individuals with high levels of physical activity (PA). However, the association between increased CAC a physically active population and cardiovascular mortality not yet well-established. This study aimed to investigate PA presence or absence mortality. Methods: A cohort was conducted from 1 January 2011 30 December 2019. Mortality data were updated until 2020. The comprised 56,469 who had completed International...

Abstract Background Few studies have assessed the correlation between coexisting mental disorders in participants with diabetes mellitus (DM) and risk of heart failure (HF). Herein, we conducted a cohort study to determine association accumulation DM HF. Methods The Korean National Health Insurance Service records were assessed. 2,447,386 adults who underwent health screening 2009 2012 analyzed. Participants major depressive disorder, bipolar schizophrenia, insomnia, or anxiety included. In...

evident.Eventually, after extra-corporeal membrane oxygenation (ECMO), recovery was complete. CaseA 41-year-old female visited the emergency room with severe back pain without specific cause, which began day before.She had no past medical history, did not drink alcohol and never smoked.Physical examination revealed mild periumbilical tenderness rebound tenderness.There or limitation of range motion in back.Initial vital signs were non-specific, tachypnea (systolic blood pressure/diastolic...

Pulse-wave velocity (PWV) is a widely used clinical marker of arterial stiffness. Associations between several physical fitness measures and stiffness have been examined. However, these results were inconsistent. Therefore, we conducted cross-sectional study to assess the relationship various parameters in older adults. From January 2014 December 2015, 1500 participants (men, n = 587; mean age, 71.78 ± 5.10 years) South Korea enrolled study. Koreans aged >65 years who agreed participate...

Background: Although an inverse association between the N-terminal prohormone brain natriuretic peptide (NT-proBNP) and obesity exists, only few major studies have assessed NT-proBNP levels skeletal muscle mass in asymptomatic healthy adults. Therefore, this cross-sectional study was conducted.Methods: We participants who underwent health examinations at Kangbuk Samsung Hospital South Korea from January 2012 to December 2019. Appendicular measured using a bioelectrical impedance analyzer,...

Background: The effect of obesity on the development type 2 diabetes mellitus (DM) in different age groups remains unclear. We assessed impact DM for two (40-year-old, middle age; 66-year-old, older adults) Korean population.Methods: analyzed National Health Insurance Service data 4,145,321 adults with 40- and 66-year-old without DM, between 2009 2014. Participants were followed up until 2017 or diagnosis DM. risk based body mass index waist circumference participants. Multiple confounding...

Background Endocarditis is a life-threatening condition with protean manifestations. The clinical syndrome continues to evolve an aging population, the opioid epidemic, and changing microbiological profiles. Much of data for endocarditis comes from tertiary care centers on-site cardiac surgery. Previous community cohorts do not reflect current patient populations or microbiology predate epidemic. We retrospectively reviewed baseline characteristics, microbiologic spectrum, surgical...

Background: The association between low-density lipoprotein (LDL-C) levels and cardiovascular disease (CVD) risk in different age groups within the diabetes mellitus (DM) population remains unclear. cohort study was conducted to investigate this relationship.Methods: We assessed 2009 2012 Korean National Health Screening Insurance Service records, with follow-up primary outcome (myocardial infarction [MI] or stroke) December 2018. After excluding participants a history of MI stroke,...