A5045503784- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Diabetes Management and Research
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Cancer Cells and Metastasis
- Digestive system and related health
- T-cell and B-cell Immunology
- Metabolism, Diabetes, and Cancer
Humboldt-Universität zu Berlin
2024-2025
Charité - Universitätsmedizin Berlin
2020-2025
Freie Universität Berlin
2024-2025
Biomedical Research Institute of Lleida
2023
Universitat de Lleida
2023
German Rheumatism Research Centre
2020
RORγt+ group 3 innate lymphoid cells (ILC3s) maintain intestinal homeostasis through secretion of type cytokines such as interleukin (IL)-17 and IL-22. However, CCR6- ILC3s additionally co-express T-bet allowing for the acquisition 1 effector functions. While controls programming ILC3s, molecular mechanisms governing are undefined. Here, we identify c-Maf a crucial negative regulator murine T-bet+ ILC3s. Phenotypic transcriptomic profiling c-Maf-deficient revealed hyper differentiation...
The primary function of the small intestine (SI) is to absorb nutrients maintain whole-body energy homeostasis. Enterocytes are major epithelial cell type facilitating nutrient sensing and uptake. However, molecular regulators governing enterocytes have remained undefined. Here, we identify c-Maf as an enterocyte-specific transcription factor within SI epithelium. expression was determined by opposing Noggin/BMP signals overlapped with zonated enrichment transporters in mid-villus region....
Recent advancements in mucosal immunology have unveiled a complex network of intercellular connections within diverse tissues, shedding light on the unique properties different cell types. Central to this intricate is cytokine IL-33, which has gained significant attention for its critical role various diseases, from allergy cancer, triggering type 2 immune responses, among others. research challenged prior assumptions attributing IL-33 expression epithelial cells, highlighting stromal cells...
Abstract Objective Type 1 diabetes (T1D) has been associated with alterations of the gut microbiota. Here we investigate cross-talk between immune system and intestinal microbiota in murine T1D. Design To evaluate modulation T1D by microbiota, non-obese diabetic (NOD) mice were cohoused 116C-NOD B-cell transgenic model. further explore influence adaptive NOD models on their fecal studied immunodeficient variants NOD.RAG-2 -/- 116C-NOD.RAG-2 , as well a non-T1D-prone mouse control. The role B...