A5062583609- Food Allergy and Anaphylaxis Research
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Travel-related health issues
- Xenotransplantation and immune response
- Viral Infections and Immunology Research
- Eosinophilic Esophagitis
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Disorders and Syndromes
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Mast cells and histamine
- Vector-Borne Animal Diseases
- Asthma and respiratory diseases
- Celiac Disease Research and Management
- Hepatitis Viruses Studies and Epidemiology
University of Virginia
2022-2025
Nationwide Children's Hospital
2023
Abstract The recent recognition of a syndrome tick‐acquired mammalian meat allergy has transformed the previously held view that is an uncommon allergen. syndrome, mediated by IgE antibodies against oligosaccharide galactose‐alpha‐1,3‐galactose (alpha‐gal), can also involve reactions to visceral organs, dairy, gelatin and other products, including medications sourced from non‐primate mammals. Thus, fittingly, this allergic disorder now called alpha‐gal (AGS). strikingly regional, reflecting...
Three COVID-19 vaccines have received FDA-authorization and are in use the United States, but there is limited head-to-head data on durability of immune response elicited by these vaccines. Using a quantitative assay we studied binding IgG antibodies BNT162b2, mRNA-1273 or Ad26.COV2.S an employee cohort over span out to 10 months. Age sex were explored as modifiers. Of 234 subjects vaccine cohort, 114 six Ad26.COV2.S. levels measured between seven 20 days after second vaccination similar...
SummaryBackgroundAlthough proteins derived from cats are an important contributor to indoor allergen exposure in relation asthma, it has been known for at least twenty years that some children who live a house with cat can become clinically tolerant these animals. In 2001, we reported exposed high levels of allergens made IgG4 antibodies the Fel d 1, and coined term "a modified Th2 response". However, this phenomenon is still poorly understood.MethodsWe studied serum among 616 individuals...
Background: Antibodies to galactose-alpha-1,3-galactose (alpha-gal), particularly the IgM and IgG isotypes, are abundant in human sera. These antibodies known be an important xenotransplantation barrier, but full implications of these health disease remain incompletely understood. By contrast, IgE alpha-gal is uncommon population has been associated with tick bites causally linked mammalian meat allergy, often now as syndrome (AGS). To date, there have few population-based studies that...
Background/Objectives: IgE to galactose-alpha-1,3-galactose (alpha-gal) is associated with Amblyomma americanum (lone star tick) bites, accounting for the regional distribution of alpha-gal syndrome (AGS). Longitudinal studies describing risk factors incident sensitization are lacking. The objective this project was assess incidence seroconversion and identify demographic, occupational, geographical among US military personnel. Methods: Samples from Department Defense Serum Repository were...