A5045543884- Neonatal and fetal brain pathology
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Glaucoma and retinal disorders
- Gaze Tracking and Assistive Technology
- Ophthalmology and Visual Impairment Studies
- Neural dynamics and brain function
- Retinal Imaging and Analysis
- Infant Development and Preterm Care
- Neuroscience of respiration and sleep
- Older Adults Driving Studies
- Non-Invasive Vital Sign Monitoring
- Regulation of Appetite and Obesity
- Child and Animal Learning Development
- Atomic and Subatomic Physics Research
- Neuroscience and Music Perception
- Advanced MRI Techniques and Applications
- Visual Attention and Saliency Detection
- Adipose Tissue and Metabolism
- Heart Rate Variability and Autonomic Control
- French Urban and Social Studies
- Long-Term Effects of COVID-19
- Infant Health and Development
- Hallucinations in medical conditions
- Cognitive Abilities and Testing
German Center for Diabetes Research
2019-2024
University of Tübingen
2014-2024
University Children's Hospital Tübingen
2020-2023
Heinrich Heine University Düsseldorf
2019-2023
Deutsches Diabetes-Zentrum e.V.
2019-2023
Institute of Diabetes Research
2022
TH Bingen University of Applied Sciences
2019
Post-chiasmal visual pathway lesions and glaucomatous optic neuropathy cause binocular field defects (VFDs) that may critically interfere with quality of life driving licensure. The aims this study were (i) to assess the on-road performance patients suffering from loss using a dual-brake vehicle, (ii) investigate related compensatory mechanisms. A instructor, blinded participants' diagnosis, rated (passed/failed) ten homonymous (HP), including four right (HR) six left (HL), glaucoma (GP),...
Advanced glaucomatous visual field loss may critically interfere with quality of life. The purpose this study was to (i) assess the impact binocular on a supermarket search task as an example everyday living activities, (ii) identify factors influencing performance, and (iii) investigate related compensatory mechanisms. Ten patients glaucoma (GP), ten healthy-sighted control subjects (GC) were asked collect twenty different products chosen randomly in two racks quickly possible. performance...
The concept of fetal consciousness is a widely discussed topic. In this study, we applied hierarchical rule learning paradigm to investigate the possibility conscious processing during last trimester pregnancy. We used magnetoencephalography, assess brain activity in 56 healthy fetuses between gestational week 25 and 40, an auditory oddball containing first- second-order regularities. comparison responses towards standard deviant tones revealed that investigated show signs learning, thus...
Advanced age, followed by male sex, far poses the greatest risk for severe COVID-19. An unresolved question is extent to which modifiable comorbidities increase of COVID-19-related mortality among younger patients, in whom hospitalization strongly increased 2021. A total 3,163 patients with SARS-COV-2 diagnosis Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort were studied. LEOSS a non-interventional multi-center study established March 2020 investigate epidemiology...
Physical activity (PA) during pregnancy may have a positive effect on the fetal autonomic nervous system maturation which are reflected in decreasing resting heart rate and increasing variability (HRV). Different types of PA, for example leisure or work time, have, however, differential effects HRV, but this relationship has not yet been investigated pregnancy. In our work, we related different PA with maternal HRV. We assessed levels 95 pregnant women between 28-32 weeks gestational age...
The fetal autonomic nervous system (ANS) is believed to be negatively affected by maternal adverse emotional states. In this study, we evaluated how depression, anxiety and stress during pregnancy are related heart rate variability (HRV) as recorded with magnetocardiography (MCG). We also considered metabolic factors such adiposity circulating levels of cortisol gestation. Furthermore, followed up these fetuses after birth, recording HRV saliva in infants establish any effects postpartum.We...
Homonymous visual field defects (HVFDs) may critically interfere with quality of life. The aim this study was to assess the impact HVFDs on a supermarket search task and investigate influence performance.Ten patients (four right-sided [HR] six left-sided defect [HL]), 10 healthy-sighted, sex-, age-matched control subjects were asked collect 20 products placed two shelves as quickly possible. Task performance rated "passed" or "failed" regard time per correctly collected item (TC -failed =...
Estimating the extent to which newborn humans process input from their environment, especially regarding depth of processing, is a challenging question. To approach this problem, we measured brain responses in 20 newborns with magnetoencephalography (MEG) "local-global" auditory oddball paradigm two-levels hierarchical regularities are presented. Results suggest that infants first weeks life able learn rules, yet certain level vigilance seems be necessary. Newborns detected violations...
Abstract Fetal behavioural states (fBS) describe periods of fetal wakefulness and sleep are commonly defined by features such as body eye movements heart rate. Automatic state detection through algorithms relies on different parameters thresholds derived from both the rate variability (HRV) actogram, which highly dependent specific datasets prone to artefacts. Furthermore, development is dynamic over gestational period evaluation usually only separated into early late gestation (before after...
Abstract In nature, biological systems such as the human brain are characterized by complex and non-linear dynamics. One way of quantifying signal complexity is Multiscale Entropy (MSE), which suitable for structures with long-range correlation at different time scales. developmental neuroscience, MSE can be taken an index maturation, differentiate between healthy pathological development. our current work, we explored trends on basis 30 simultaneous EEG – fNIRS recordings in premature...
Fetal magnetoencephalography (fMEG) is a method to record human fetal brain signals in pregnant mothers. Nevertheless the amplitude of signal very small and overlaid by interfering mainly caused maternal heart activity. Several methods are used attenuate for extraction signal. However currently often affected reduction or redistribution To overcome this limitation we developed new fully automated procedure removal activity (FAUNA) based on Principal Component Analysis (PCA) Ridge Regression....
Detection of fetal brain signals in magnetoencephalographic recordings is – due to the low signal noise ratio challenging for researchers this field. Up now, state art a manual evaluation signal. To make more reproducible and less time consuming, an approach using Principal Component Analysis introduced. Locations channels most importance first three principal components are taken into account their possibility resembling activity evaluated. Data with auditory stimulation analysis trigger...
Abstract A large body of electroencephalography (EEG) studies has characterized the spontaneous neural activity premature neonates at different gestational ages. However, evaluation normal and pathological fetal brain development is still a challenge due to complexity extraction analysis activity. Fetal magnetoencephalography (fMEG) currently only available technique record with time resolution equivalent that EEG. signatures characteristics are largely unknown. Benefiting from progress in...
Measures of neural complexity have been shown to evolve with age during the earliest weeks infancy and differentiate between typical atypical development, suggesting that they may be promising surrogate markers brain maturation. In our current work, we explored developmental trends in goals better understanding what drives age-related changes replicating previously reported sex-related differences age-equivalent fetuses. Toward this end, employed three different measures derived from...
Abstract Estimating the extent to which newborn humans process input from their environment, especially regarding depth of processing, is a challenging question. To approach this problem, we measured brain responses in 20 newborns with magnetoencephalography (MEG) “local-global” auditory oddball paradigm two-levels hierarchical regularities are presented. Results suggest that infants first weeks life able learn rules, yet certain level vigilance seems be necessary. Newborns detected...
Abstract The concept of fetal consciousness is a widely discussed topic. In this study, we applied hierarchical rule learning paradigm to investigate the possibility conscious processing during last trimester pregnancy. We used magnetoencephalography, assess brain activity in 56 healthy fetuses between gestational week 25 and 40, an auditory oddball containing first- second-order regularities. comparison responses towards standard deviant tones revealed that investigated show signs learning,...
The orexigenic peptide hormone ghrelin has been implicated in the pathophysiology of obesity and type 2 diabetes mellitus through its effects on nutrient homeostasis. Ghrelin is subject to a unique post-translational acyl modification regulating biochemical activity.In this study we aimed investigate relation acylated (AcG) as well unacylated (UnG) with body weight insulin resistance fasting (n = 545) post-oral glucose tolerance test (oGTT) state 245) metabolically characterized cohort...