A5010963236- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Neurological diseases and metabolism
- DNA Repair Mechanisms
- Neurological and metabolic disorders
- Psychosomatic Disorders and Their Treatments
- Cerebral Palsy and Movement Disorders
- Olfactory and Sensory Function Studies
- Hereditary Neurological Disorders
- Parkinson's Disease and Spinal Disorders
- Obsessive-Compulsive Spectrum Disorders
- Restless Legs Syndrome Research
- Neurology and Historical Studies
- Balance, Gait, and Falls Prevention
- Coffee research and impacts
- Autoimmune Neurological Disorders and Treatments
- Body Image and Dysmorphia Studies
- Nutrition and Health in Aging
- Drug-Induced Ocular Toxicity
- Amyotrophic Lateral Sclerosis Research
- Mental Health and Psychiatry
- Vestibular and auditory disorders
University of Lübeck
2019-2025
University Hospital Schleswig-Holstein
2019-2025
Kiel University
2018-2024
Hospital de Clínicas Universidade Federal do Paraná
2011-2024
Universidade Federal do Paraná
2011-2024
Pontifícia Universidade Católica do Paraná
2010-2017
University of Ottawa
2017
McGill University
2012-2017
Montreal General Hospital
2012-2017
University of Manitoba
2017
Epidemiologic studies consistently link caffeine, a nonselective adenosine antagonist, to lower risk of Parkinson disease (PD). However, the symptomatic effects caffeine in PD have not been adequately evaluated.We conducted 6-week randomized controlled trial assess upon daytime somnolence, motor severity, and other nonmotor features. Patients with somnolence (Epworth >10) were given 100 mg twice daily ×3 weeks, then 200 or matching placebo. The primary outcome was Epworth Sleepiness Scale...
Gait dysfunction is a common target for pharmacological, behavioral, and surgical interventions in persons with Parkinson disease. However, the responsiveness of gait speed, that is, clinically important difference, not well described literature this population. The purpose study was to determine magnitude meaningful difference speed using multiple methods assessment utilizing large sample participants inclusive various stages disease severity.Gait measured an instrumented walkway 324...
To assess effects of caffeine on Parkinson disease (PD).In this multicenter parallel-group controlled trial, patients with PD 1-8 years duration, Hoehn & Yahr stages I-III, stable symptomatic therapy were randomized to 200 mg BID vs matching placebo capsules for 6-18 months. The primary research question was whether objective motor scores would differ at 6 months (Movement Disorder Society-sponsored Unified Parkinson's Disease Rating Scale [MDS-UPDRS]-III, Class I evidence). Secondary...
Background: Ocular motor abnormalities reflect the varied neuropathology of spinocerebellar ataxias (SCAs) and may serve to clinically distinguish different SCAs. We analyzed various eye movement detected prospectively at baseline visit during a large multicenter natural history study SCAs 1, 2, 3, 6. Methods: The data were collected from 12 centers in United States patients with 6, as part Clinical Research Consortium for Spinocerebellar Ataxias (NIH-CRC-SCA). Patient characteristics,...
Aim: Investigate the experiences, challenges, and difficulties faced by people with Parkinson's disease (PD) when using standard cutlery during meals explore their preferences for features in assistive cutlery.
Spinocerebellar ataxia type 3 (SCA3) involves cerebellar, pyramidal, extrapyramidal, motor neuron and oculomotor systems with strong phenotypic heterogeneity, that lead us to classify the disorder into different clinical subtypes according predominantly affected systems.The series comprises 167 SCA3 patients belonging 68 pedigrees, studied from 1989-2013. These were categorized seven subphenotypes.SCA3 cases clustered predominant features. Three most common forms subphenotype 2,...
The main clinical manifestations of the spinocerebellar ataxias (SCAs) result from involvement cerebellum and its connections. Cerebellar activity has been consistently observed in functional imaging studies olfaction, but anatomical pathways responsible for this connection have not yet elucidated. Previous demonstrated olfactory deficit SCA2, Friedreich9s ataxia small groups diverse aetiology. authors used a validated version 16-item smell identification test Sniffin9 Sticks (SS-16) was to...
Motor and cognitive deficits consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis the evaluation of treatment this vulnerable cohort limited. aims ComOn (COgnitive interactions Older populatioN) study (i) to define quantitative markers with clinical relevance motor deficits, (ii) investigate interaction between both (iii) assess health status as well outcome 1000 inpatients hospitals Kiel (Germany), Brescia (Italy), Porto (Portugal),...
Background and purpose Non‐motor manifestations are frequently overlooked in degenerative disorders little is known about their frequency clinical relevance SPG4 hereditary spastic paraplegia (SPG4‐HSP). Methods Thirty patients with SPG4‐HSP 30 healthy controls answered the Modified Fatigue Impact Scale, Epworth Sleepiness Brief Pain Inventory Beck Depression Inventory. Student's t test was used to compare groups linear regression assess correlations. Results Patients had higher fatigue...
<b><i>Background:</i></b> Movement disorders (MDs) are well recognized in all subtypes of spinocerebellar ataxias (SCA), but phenomenology and frequency vary widely. <b><i>Methods:</i></b> Three hundred seventy-eight patients, from 169 Brazilian families, with SCAs were assessed neurological examination molecular genetic testing. <b><i>Results:</i></b> Dystonia was the most common movement disorder, found 5.5%...
ABSTRACT Motor and non-motor manifestations are common disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity may improve gait in these patients. Little known about the effects Btx-A on symptoms HSP Objective To assess efficacy motor Methods Thirty-three adult patients with a clinical molecular diagnosis were evaluated before after injections. Results Mean age was 41.7 ± 13.6 years there 18 women. Most had pure...
Large expansions of microsatellite DNA cause several neurological diseases. In Spinocerebellar ataxia type 10 (SCA10), the repeat interruptions change disease phenotype; an (ATTCC)n or a (ATCCT)n/(ATCCC)n interruption within (ATTCT)n is associated with robust phenotype and epilepsy while mostly pure may have reduced penetrance. SCA10, many other expansions, can exceed 10,000 base pairs (bp) in size. Conventional next generation sequencing (NGS) technologies are ineffective determining...