A5025359870- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Glycogen Storage Diseases and Myoclonus
- Neurological diseases and metabolism
- Cerebral Palsy and Movement Disorders
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Autoimmune Neurological Disorders and Treatments
- Cellular transport and secretion
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Neurological and metabolic disorders
- Amyotrophic Lateral Sclerosis Research
- CNS Lymphoma Diagnosis and Treatment
- Prion Diseases and Protein Misfolding
- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Parkinson's Disease and Spinal Disorders
- Stroke Rehabilitation and Recovery
- RNA regulation and disease
- Nuclear Receptors and Signaling
University of Lübeck
2016-2024
Kiel University
2015-2024
University Hospital Schleswig-Holstein
2016-2024
Carl von Ossietzky Universität Oldenburg
2019
University of Florida
2019
Klinik und Poliklinik für Neurologie
2018
University Medical Center Hamburg-Eppendorf
2013-2015
Universität Hamburg
2013-2015
Deep brain stimulation (DBS) of the ventral intermediate thalamic nucleus (Vim) is established for medically refractory severe essential tremor (ET), but long-term efficacy controversial.Twenty patients with ET DBS had standardized video-documented examinations at baseline, in stimulation-on condition short term (13.1 ± 1.9 months since surgery, mean SEM), and stimulator switched on off (stim-ON/OFF) long term; all assessments were done between 32 120 (71.9 6.9 months) after implantation....
Abstract Introduction The aim of this German national guideline is to optimize the clinical care patients with Parkinson's disease (PD) in terms diagnostics, drug and surgical treatment care. Summary or definition topic This guidance was prepared for Society Neurology (DGN) collaboration Austrian (ÖGN) Swiss Neurological (SNG) German-speaking countries. guidelines diagnosis PD have been revised by a expert group commission DGN at S2k level. main objective these regarding diagnosis, including...
Impulse control disorders (ICD), psychosis and delirium are part of the spectrum behavioural changes associated with Parkinson's disease (PD). The diagnostic therapeutic management these rather complex neuropsychiatric conditions has been updated in clinical guideline by German Society Neurology (DGN).
Autoimmune encephalitis can be classified into antibody-defined subtypes, which manifest with immunotherapy-responsive movement disorders sometimes mimicking non-inflammatory aetiologies. In the elderly, anti-LGI1 and contactin associated protein like 2 (CASPR2) antibody-associated diseases compose a relevant fraction of autoimmune encephalitis. Patients LGI1 autoantibodies are known to present limbic additionally faciobrachial dystonic seizures may occur. However, clinical spectrum CASPR2...
Patients with upper limb action tremor frequently exhibit additional neurological signs of uncertain significance. Clinicians vary in their interpretation, and interrater agreement on the final diagnosis is poor.A new clinical tool for assessing presence or absence that are important axis-1 classification patients introduced: Standardized Tremor Elements Assessment (STEA). Interrater determined, leading to disagreement identified.Three tremor-focussed one dystonia-focussed movement disorder...
Idiopathic Parkinson's disease (PD) is a complex multifactorial disorder caused by the interplay of both genetic and non-genetic risk factors. Polygenic scores (PRSs) are one way to aggregate effects large number variants upon for like PD in single quantity. However, reassessment performance given PRS independent data sets precondition establishing as valid tool this end. We studied previously proposed separate set, comprising 1914 cases 4464 controls, were able replicate its ability...
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective and evidence-based treatment for idiopathic Parkinson's disease (iPD). A minority patients does not sufficiently benefit from STN-DBS.The predictive validity levodopa challenge individual analyzed.Data assessed with a preoperative Levodopa-test follow-up examination (mean ± standard deviation: 9.15 months ±3.39) Kiel (n = 253), Berlin 78) Toronto 98) were studied. Insufficient DBS outcome was defined as overall...
Motor and cognitive deficits consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis the evaluation of treatment this vulnerable cohort limited. aims ComOn (COgnitive interactions Older populatioN) study (i) to define quantitative markers with clinical relevance motor deficits, (ii) investigate interaction between both (iii) assess health status as well outcome 1000 inpatients hospitals Kiel (Germany), Brescia (Italy), Porto (Portugal),...
Thalamic deep brain stimulation (DBS) is established for medically refractory tremor syndromes and globus pallidus (GPi-DBS) dystonia syndromes. For combined syndromes, the best target unclear.We present four patients with two different profiles whose clinical course demonstrates that our current analysis of symptomatology not a sufficient predictor surgical success.Outcome parameters were assessed observer-blinded video ratings included Fahn-Tolosa-Marin-Tremor Rating Scale (FTM-TRS)...
Abstract Background Pathogenic variants in several genes have been linked to genetic forms of isolated or combined dystonia. The phenotypic and spectrum the frequency pathogenic these not yet fully elucidated, neither patients with dystonia nor other, sometimes co‐occurring movement disorders such as Parkinson's disease (PD). Objectives To screen >2000 PD for rare known dystonia‐causing genes. Methods We screened 1207 from Germany (DysTract consortium), Spain, South Korea, 1036 using a...
The clinical benefit of mechanical recanalization procedures for acute stroke is still a matter debate. We report the and imaging results 34 consecutive patients, focusing on time aspects (i.e. vessel occlusion procedure duration).During 3-year period, patients with large-vessel (anterior circulation, n = 19; posterior 15) were treated several devices (n 17) or without prior intravenous thrombolysis. Clinical data before (NIHSS) after treatment [(mRS) 3 6-30 months] analyzed. angiographic...
Abstract Background Unilateral or very asymmetric upper limb tremors with a jerky appearance are poorly investigated. Their clinical classification is an unsolved problem because their as essential tremor versus dystonic uncertain. To avoid misclassification premature tremor, the term indeterminate was suggested. Objectives The aim of this study to characterize subgroup electrophysiologically and evaluate whether diagnostically meaningful electrophysiological differences exist compared...
Background Freezing of gait (FOG) in Parkinson’s disease (PD) is associated with asymmetry and switching difficulty. A split-belt treadmill may potentially address those deficits. Objective To investigate the immediate retention effects one-session training (SBT) contrast to regular tied-belt (TBT) on adaptation people PD FOG (PD + FOG) healthy controls (HC). Additionally, differential 3 SBT protocols compare different outcomes. Methods (n = 45) HC 36) were randomized 1 groups (belt speeds’...
Abstract Essential tremor (ET) amplitude is modulated by visual feedback during target driven movements and in a grip force task. It has not been examined yet whether exclusively modulates or if other afferent inputs like auditory sensation modulatory effect on as well. Also, it unknown the enhanced sensory causes an increase of arousal persons with ET (p-ET). We hypothesized that (1) variation absence paradigm; (2) coincides pupillary size measure arousal. 14 p-ET matched healthy controls...
Abstract Background Head tremor is common in dystonia syndromes and difficult to treat. Deep brain stimulation (DBS) a therapeutic option medically‐refractory cases. In most DBS‐centers, the globus pallidus internus (GPi) targeted patients with predominant ventrointermediate nucleus of thalamus (Vim) tremor. The aim study was evaluate effect GPi‐ versus Vim‐DBS dystonic or essential head Methods All (ET) (n = 381) who underwent DBS surgery at our institution between 1999 2020 were screened...
Abstract Background Tremor is commonly found among healthy humans or prevalently a symptom of neurological dysfunctions. However, the distinction between physiological and pathological tremor dependent on examiner's competence. Archimedes Spiral Rating (ASR) valid reproducible semi‐quantitative method to assess severity action tremor. Objectives (1) To range percentiles ASR in large sample seemingly free tremor‐related conditions symptoms from population‐based CHRIS‐study. (2) analyze...
Background: Essential tremor (ET) occurs with steeply increasing prevalence in the elderly, and apart from disease duration, age is independently associated an increase of amplitude a decrease frequency. White matter hyperintensities (WMHs) are common finding their role pathophysiology ET unknown. The aims this study were to examine whether patients differ total or region-specific WMH volumes healthy controls determine impact on characteristics. Methods: A 47 elderly mean 72 years 39...