A5029411924- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cancer Cells and Metastasis
- Cancer Risks and Factors
- Endometriosis Research and Treatment
- Health Literacy and Information Accessibility
- Uterine Myomas and Treatments
- Surgical Simulation and Training
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Colorectal Cancer Surgical Treatments
- Monoclonal and Polyclonal Antibodies Research
- Adipokines, Inflammation, and Metabolic Diseases
- Caveolin-1 and cellular processes
- Cancer Genomics and Diagnostics
- Galectins and Cancer Biology
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer therapeutics and mechanisms
- Gynecological conditions and treatments
- Intestinal and Peritoneal Adhesions
- Cell death mechanisms and regulation
- Reproductive System and Pregnancy
- Cancer survivorship and care
- Glycosylation and Glycoproteins Research
Billings Clinic
2021
Cleveland Clinic
2017-2020
Cleveland Clinic Lerner College of Medicine
2017-2020
The Ohio State University
2020
University of Kansas Medical Center
2020
Women & Infants Hospital of Rhode Island
2015
Brown University
2013-2015
University of Virginia
2012
Effective targeting of cancer stem cells (CSCs) requires neutralization self-renewal and chemoresistance, but these phenotypes are often regulated by distinct molecular mechanisms. Here we report the ability to target both via CD55, an intrinsic cell surface complement inhibitor, which was identified in a comparative analysis between CSCs non-CSCs endometrioid models. In this context, CD55 functions complement-independent manner required lipid raft localization for CSC maintenance cisplatin...
Abstract Background Ovarian cancer is the leading cause of gynecologic death in United States despite effective first-line systemic chemotherapy. Cancer stem cells (CSCs) retain ability to self-renew and proliferate may be a means harboring disease that evades standard treatment strategies. We previously performed high-throughput screen assess differential protein expression ovarian CSCs compared non-CSCs observed Thy-1 was more highly expressed CSCs. Our primary aim validate (CD90) as cell...
To identify young patients with endometrial cancer potential Lynch-related DNA mismatch repair (MMR) protein expression defects and stathmin (STMN1) (part of the phosphoinositol 3-kinase pathway) to correlate clinical data. This retrospective study included women who were 50 years or younger at diagnosis. Clinical data abstracted from chart review. Immunohistochemistry for MMR expression, STMN1, pSTMN1 was performed univariate analyses performed. The mean age 111 43 years, body mass index...
ABSTRACT Effective targeting of cancer stem cells (CSCs) requires neutralization self-renewal and chemoresistance, however these phenotypes are often regulated by distinct molecular mechanisms. Here we report the ability to target both via CD55, an intrinsic cell surface complement inhibitor, which was identified in a comparative analysis between CSCs non-CSCs endometrioid models. In this context, CD55 functions complement-independent manner required lipid raft localization for CSC...
Abstract Background Ovarian cancer is the most fatal gynecologic malignancy in United States. While chemotherapy effective vast majority of ovarian patients, recurrence and resistance to standard systemic therapy nearly inevitable. We discovered that activation non-receptor tyrosine kinase Lymphocyte Cell-Specific Protein-Tyrosine Kinase (LCK) promoted cisplatin resistance. Here, we hypothesized treating high grade, platinum resistant endometrioid cells with an LCK inhibitor (LCKi) followed...
The objective of this study was to assess the scope intestinal surgery training across gynecologic oncology fellowships in United States and identify factors associated with perceived preparedness perform independently.An institutional review board-approved survey distributed Society Gynecologic Oncology fellows candidate members within first 3 years practice. Questions addressed demographics, operative experience, plans for performing surgery, attitudes toward oncologists (GOs) surgery....
Abstract Background: Ovarian cancer is the most fatal gynecologic malignancy in United States. While chemotherapy effective vast majority of ovarian patients, recurrence and resistance to standard systemic therapy nearly inevitable. We discovered that CD55 via activation non-receptor tyrosine kinase Lymphocyte Cell-Specific Protein-Tyrosine Kinase (LCK) promoted cisplatin resistance. Here, we hypothesized treating high grade, platinum resistant endometrioid cells with an LCK inhibitor (LCKi)...
Background: Cervical rhabdomyosarcoma is very rare, comprising less than 1% of cervical cancers in adult women. Less 40 cases have been reported women the last 50 years. Due to rarity this disease, management guidelines are non-existent. Case: We present a 36-year-old woman who presented with pelvic pain and vaginal mass. The mass was excised, pathology confirmed poorly differentiated embryonal type rhabdomyosarcoma. She then underwent total laparoscopic hysterectomy bilateral salpingectomy...